:l Excellent Read....Ready for some science again?!
Mood Foods: How Amino Acids Feed Your Brain
The four key mood chemicals (neurotransmitters) are made of amino acids. There are at least twenty-two amino acids contained in protein foods. High-protein foods, such as fish, eggs, chicken and beef, contain all twenty-two, including the nine amino acids that are considered essential for humans. Other foods, such as grains and beans, have some but not all of the essential nine aminos, so they need to be carefully combined to provide a complete protein (for example, rice and beans, or corn and nuts).
If you are eating three meals a day, each meal including plenty of protein (most people with eating and weight problems are doing neither), your positive moods and freedom from cravings can be maintained. But most people need to kick-start the brain's repair job, using certain key amino acids. This will allow you to actually enjoy eating protein and vegetables instead of cookies and ice cream. After a few months, you will be getting all the aminos you need from your food alone and won't need to take amino acids as supplements any longer.
Restoring depleted brain chemistry sounds like a big job?but it isn't. Three of the four neurotransmitters that color all your moods are made from just a single amino acid each! Because biochemists have isolated the key amino acids, you can easily add the specific ones that may be deficient. These ?free form? amino acids are instantly bioavailable (in other words, they are predigested), unlike protein powders from soy or milk, which can be hard to absorb. Hundreds of research studies at Harvard, MIT and elsewhere (some of which date back to the early part of this century) have confirmed the effectiveness of using just a few targeted amino acid ?precursors? to increase the key neurotransmitters, thereby eliminating depression, anxiety and cravings for food, alcohol and drugs.
Stopping Carbohydrate Cravings
It may sound impossible, but you can stop your food cravings almost instantly with just one amino acid supplement. Any absence of fuel for your brain's functions is perceived correctly by your body as a code-red emergency. Powerful biochemical messages then order you to immediately eat refined carbohydrates to quickly fuel your brain. There are only two fuels that the brain can readily use:
1. glucose, which is blood sugar made from sweets, starches, or alcohol;
2. L-glutamine, an amino acid available in protein foods (or as a supplement, carried in all health food stores).
L-glutamine reaches the starving brain within minutes and can often immediately put a stop to even the most powerful sweet and starch cravings. The brain is fueled by L-glutamine when glucose levels drop too low. Don't be intimidated by the strong effects of supplementation. L-glutamine is a natural food substance; in fact, it's the most abundant amino acid in our bodies. It serves many critical purposes: stabilizing our mental functioning, keeping us calm yet alert, and promoting good digestion.
Restoring Energy and Focus
When your brain is adequately fueled with its back-up emergency supplies of L-glutamine, you are ready to rebuild your four key neurotransmitters, starting with dopamine/norepinephrine, your natural caffeine. Without this natural brain stimulant, you can be slow and tired and have a hard time concentrating. You don't sparkle and can't stay on track mentally. It's hard to get things done and you can feel dull and sometimes just want to stay in bed. Your physical as well as your mental energy drops without adequate norepinephrine. The amino acid that provides this jet-fuel is the nutritional powerhouse L-tyrosine. L-tyrosine produces thyroid hormones and adrenaline as well as norepinephrine. Like L-glutamine, L-tyrosine goes to work in minutes to perk you up.
Enhancing Your Ability to Relax
The next key mood-enhancing chemical is GABA (gamma amino butyric acid), our natural Valium. GABA acts like a sponge, soaking up excess adrenaline and other by-products of stress and leaving us relaxed. It seems to drain the tension and stiffness right out of knotted muscles. GABA can even smooth out seizure activity in the brain. My colleague Elliot Wagner, a specialist in drug detox, taught me that GABA can even give relief to heroin addicts going through the severe anxiety of early withdrawal. Think what it can do for garden variety stress and uptightness!
When Food is Comfort
For many people, overeating helps compensate for a depletion of the natural pain relievers, the endorphins. Life's pain can be unendurable without adequate amounts of these buffer chemicals. Some of us (for example, those of us from alcoholic families) may be born with too little natural pain tolerance. We are overly sensitive to emotional (and sometimes physical) pain. We cry easily. Like our alcoholic parents, we need something to help us endure our daily lives, which seem so painful. Others of us use up too much endorphins through trauma and stress. We just run out, especially if we were born short on endorphins to begin with. When our comfort chemicals run low, many of us turn to comfort foods.
If you need food as a reward and a treat, or to numb your feelings, your natural pleasure enhancers, the pain-killing endorphins, are probably in short supply. Foods that elevate your endorphin activity can easily become addictive. If you ?love? certain foods, those foods are firing a temporary surge of endorphins. Euphoria, joy, the ?runner's high??these are all feelings produced by endorphins. Some people have so much natural endorphins that they smile all the time and get great pleasure from everyday life. Of course, we all endure suffering and loss. But, with enough endorphins, we can bounce back.
For anorectics and bulimics, the trauma of starving and vomiting can trigger an addictive endorphin high, because trauma of any kind can set off an automatic burst of soothing endorphins. You may know of people who felt no pain for hours after a terrible physical injury. Runners don't get their big endorphin high until they have run past ?the wall of pain.? At that point, they have run too far!
Raising Serotonin, Our Natural Prozac
Low serotonin can be the easiest deficiency of all to develop. Very few foods are high in the amino acid tryptophan, which is the only nutrient that the body can use to make serotonin. According to a 1997 Lancet study, tryptophan is one of the first nutrients to be depleted by weight-loss dieting. If, in addition to dieting, you inherited low serotonin levels and experience a lot of stress, your
levels can fall low enough to set off a major eating disorder or serious emotional disturbances.
Restoring your serotonin levels can be a life-or-death matter. Suicides and violent crimes are closely associated with deficiencies of serotonin. The sometimes fatal obsessions and self-hate of bulimics and anorectics are clearly linked to low serotonin levels as well.
Do you have any obsessions that might be caused by low serotonin levels? The women I have worked with who report obsessive behavior tend to be ?neat-niks? and suffer from negative obsessing about their physical appearance, while the men are often ?neat-freaks,? although they also complain about troubling sexual fantasies they can't stop. As we all know, anorectics (who are low in serotonin) are driven to obsessive control of their food intake. Obsessive fears and phobias are common among people with low serotonin levels.
It may be a difficult adjustment for you to begin to see symptoms like control, fear and low self-esteem as biochemical problems, not just psychological ones. But the success of drugs like Prozac has already alerted us to the biochemical nature of many symptoms that don't respond to psychological help alone.
Drugs like Prozac are called serotonin reuptake inhibitors (SSRIs) because they keep whatever serotonin we have active. But they do not actually provide additional serotonin. For this reason, most people using SSRIs often continue to have some low-serotonin symptoms. Before there were SSRIs, the pharmaceutical compound L-tryptophan was commonly used to increase serotonin levels. For more than twenty years, psychiatrists and health food stores enthusiastically recommended it for relieving depression and food cravings and normalizing sleep without side effects. Many people found that their symptoms were eliminated permanently after only a few months of L-tryptophan use.
In 1989 a series of bad batches of L-tryptophan, which killed forty people and made many more very sick, prompted the Food and Drug Administration (FDA) to stop all U.S. sales. One Japanese company, Showa Denko, had produced all of these batches, which, it was found, were contaminated because they had eliminated three filter systems that they'd been using for years?just why they chose to take away these safety filters is a question that remains unanswered. Showa Denko has never made tryptophan again. Despite evidence that no other manufacturer has ever made a problem batch, the FDA recommended for years that L-tryptophan not be used as a supplement. (Interestingly, they have made no effort to stop the sale of infant formulas, most of which contain added L-tryptophan.)
With L-tryptophan unavailable, drugs like Prozac, Zoloft and Redux have become our primary tools for combating the crippling symptoms of low serotonin. Unfortunately, these drugs provide only temporary and incomplete benefits, and often have uncomfortable or dangerous side effects. Fortunately, in 1996, many compounding pharmacies began providing L-tryptophan again, by physician prescription, and a new version of tryptophan called 5HTP (5-hydroxytryptophan) became available over the counter in 1998 without FDA opposition. In 2000, Lidtke Technologies Corporation of Phoenix, Arizona, made L-tryptophan available through health professionals without prescription. Look for other supplement suppliers to follow suit, as the FDA has never formally banned the sale of this essential amino acid.
Whatever mood-enhancing brain chemicals you have in short supply, they can be replenished quickly, easily and safely.
Tryptophan Depletion:The Path to Depression, Low Self-Esteem, Obsession and Eating Disorders
Serotonin, perhaps the most well known of the brain's four key mood regulators, is made from the amino acid L-tryptophan. Because few foods contain high amounts of tryptophan, it is one of the first nutrients that you can lose when you start dieting. A new study shows that serotonin levels can drop too low within seven hours of tryptophan depletion. Let's follow this single essential protein (there are nine altogether) as it becomes more and more deeply depleted by dieting, to see how decreased levels of even one brain nutrient might turn you toward depression, compulsive eating, bulimia or anorexia.
In his best seller, Listening to Prozac, Peter Kramer, M.D., explains that when our serotonin levels drop, so do our feelings of self-esteem, regardless of our actual circumstances or accomplishments. These feelings can easily be the result of not eating the protein foods that keep serotonin levels high. As their serotonin-dependent self-esteem drops, girls tend to diet even more vigorously. ?If I get thin enough, I'll feel good about myself again!? Tragically, they don't know that they will never be thin enough to satisfy their starving minds. Extreme dieting is actually the worst way to try to raise self-esteem because the brain can only deteriorate further and become more self-critical as it starves. More and more dieters worldwide are experiencing this miserable side effect of weight reduction on the brain.
When tryptophan deficiency causes serotonin levels to drop, you may become obsessed by thoughts you can't turn off or behaviors you can't stop. Once this rigid behavior pattern emerges in the course of dieting, the predisposition to eating disorders is complete. Just as some low-serotonin obsessive-compulsives wash their hands fifty times a day, some young dieters may begin to practice a constant, involuntary vigilance regarding food and the perfect body. They become obsessed with calorie counting, with how ugly they are, and with how to eat less and less. As they eat less, their serotonin levels fall farther, increasing dieters' obsession with undereating. As their zinc and B vitamin levels drop low as well, their appetite is lost. This can be the perfect biochemical setup for anorexia.
What so many therapists and others have observed as the central issue of ?control? in anorexia often comes down to this: just as vitamin C deficiency (scurvy) results in an outbreak of red spots, do does tryptophan (and serotonin) deficiency result in an outbreak of the obsessive-compulsive behavior that we call ?control.? There may be psychological elements in the picture, too, but a low-serotonin brain is ill equipped to resolve them.
Excerpted from The Diet Cure, by Julia Ross, www.dietcure.com. We extend our grateful acknowledgement to Julia Ross for permission to reprint.
Mood Foods: How Amino Acids Feed Your Brain
The four key mood chemicals (neurotransmitters) are made of amino acids. There are at least twenty-two amino acids contained in protein foods. High-protein foods, such as fish, eggs, chicken and beef, contain all twenty-two, including the nine amino acids that are considered essential for humans. Other foods, such as grains and beans, have some but not all of the essential nine aminos, so they need to be carefully combined to provide a complete protein (for example, rice and beans, or corn and nuts).
If you are eating three meals a day, each meal including plenty of protein (most people with eating and weight problems are doing neither), your positive moods and freedom from cravings can be maintained. But most people need to kick-start the brain's repair job, using certain key amino acids. This will allow you to actually enjoy eating protein and vegetables instead of cookies and ice cream. After a few months, you will be getting all the aminos you need from your food alone and won't need to take amino acids as supplements any longer.
Restoring depleted brain chemistry sounds like a big job?but it isn't. Three of the four neurotransmitters that color all your moods are made from just a single amino acid each! Because biochemists have isolated the key amino acids, you can easily add the specific ones that may be deficient. These ?free form? amino acids are instantly bioavailable (in other words, they are predigested), unlike protein powders from soy or milk, which can be hard to absorb. Hundreds of research studies at Harvard, MIT and elsewhere (some of which date back to the early part of this century) have confirmed the effectiveness of using just a few targeted amino acid ?precursors? to increase the key neurotransmitters, thereby eliminating depression, anxiety and cravings for food, alcohol and drugs.
Stopping Carbohydrate Cravings
It may sound impossible, but you can stop your food cravings almost instantly with just one amino acid supplement. Any absence of fuel for your brain's functions is perceived correctly by your body as a code-red emergency. Powerful biochemical messages then order you to immediately eat refined carbohydrates to quickly fuel your brain. There are only two fuels that the brain can readily use:
1. glucose, which is blood sugar made from sweets, starches, or alcohol;
2. L-glutamine, an amino acid available in protein foods (or as a supplement, carried in all health food stores).
L-glutamine reaches the starving brain within minutes and can often immediately put a stop to even the most powerful sweet and starch cravings. The brain is fueled by L-glutamine when glucose levels drop too low. Don't be intimidated by the strong effects of supplementation. L-glutamine is a natural food substance; in fact, it's the most abundant amino acid in our bodies. It serves many critical purposes: stabilizing our mental functioning, keeping us calm yet alert, and promoting good digestion.
Restoring Energy and Focus
When your brain is adequately fueled with its back-up emergency supplies of L-glutamine, you are ready to rebuild your four key neurotransmitters, starting with dopamine/norepinephrine, your natural caffeine. Without this natural brain stimulant, you can be slow and tired and have a hard time concentrating. You don't sparkle and can't stay on track mentally. It's hard to get things done and you can feel dull and sometimes just want to stay in bed. Your physical as well as your mental energy drops without adequate norepinephrine. The amino acid that provides this jet-fuel is the nutritional powerhouse L-tyrosine. L-tyrosine produces thyroid hormones and adrenaline as well as norepinephrine. Like L-glutamine, L-tyrosine goes to work in minutes to perk you up.
Enhancing Your Ability to Relax
The next key mood-enhancing chemical is GABA (gamma amino butyric acid), our natural Valium. GABA acts like a sponge, soaking up excess adrenaline and other by-products of stress and leaving us relaxed. It seems to drain the tension and stiffness right out of knotted muscles. GABA can even smooth out seizure activity in the brain. My colleague Elliot Wagner, a specialist in drug detox, taught me that GABA can even give relief to heroin addicts going through the severe anxiety of early withdrawal. Think what it can do for garden variety stress and uptightness!
When Food is Comfort
For many people, overeating helps compensate for a depletion of the natural pain relievers, the endorphins. Life's pain can be unendurable without adequate amounts of these buffer chemicals. Some of us (for example, those of us from alcoholic families) may be born with too little natural pain tolerance. We are overly sensitive to emotional (and sometimes physical) pain. We cry easily. Like our alcoholic parents, we need something to help us endure our daily lives, which seem so painful. Others of us use up too much endorphins through trauma and stress. We just run out, especially if we were born short on endorphins to begin with. When our comfort chemicals run low, many of us turn to comfort foods.
If you need food as a reward and a treat, or to numb your feelings, your natural pleasure enhancers, the pain-killing endorphins, are probably in short supply. Foods that elevate your endorphin activity can easily become addictive. If you ?love? certain foods, those foods are firing a temporary surge of endorphins. Euphoria, joy, the ?runner's high??these are all feelings produced by endorphins. Some people have so much natural endorphins that they smile all the time and get great pleasure from everyday life. Of course, we all endure suffering and loss. But, with enough endorphins, we can bounce back.
For anorectics and bulimics, the trauma of starving and vomiting can trigger an addictive endorphin high, because trauma of any kind can set off an automatic burst of soothing endorphins. You may know of people who felt no pain for hours after a terrible physical injury. Runners don't get their big endorphin high until they have run past ?the wall of pain.? At that point, they have run too far!
Raising Serotonin, Our Natural Prozac
Low serotonin can be the easiest deficiency of all to develop. Very few foods are high in the amino acid tryptophan, which is the only nutrient that the body can use to make serotonin. According to a 1997 Lancet study, tryptophan is one of the first nutrients to be depleted by weight-loss dieting. If, in addition to dieting, you inherited low serotonin levels and experience a lot of stress, your
levels can fall low enough to set off a major eating disorder or serious emotional disturbances.
Restoring your serotonin levels can be a life-or-death matter. Suicides and violent crimes are closely associated with deficiencies of serotonin. The sometimes fatal obsessions and self-hate of bulimics and anorectics are clearly linked to low serotonin levels as well.
Do you have any obsessions that might be caused by low serotonin levels? The women I have worked with who report obsessive behavior tend to be ?neat-niks? and suffer from negative obsessing about their physical appearance, while the men are often ?neat-freaks,? although they also complain about troubling sexual fantasies they can't stop. As we all know, anorectics (who are low in serotonin) are driven to obsessive control of their food intake. Obsessive fears and phobias are common among people with low serotonin levels.
It may be a difficult adjustment for you to begin to see symptoms like control, fear and low self-esteem as biochemical problems, not just psychological ones. But the success of drugs like Prozac has already alerted us to the biochemical nature of many symptoms that don't respond to psychological help alone.
Drugs like Prozac are called serotonin reuptake inhibitors (SSRIs) because they keep whatever serotonin we have active. But they do not actually provide additional serotonin. For this reason, most people using SSRIs often continue to have some low-serotonin symptoms. Before there were SSRIs, the pharmaceutical compound L-tryptophan was commonly used to increase serotonin levels. For more than twenty years, psychiatrists and health food stores enthusiastically recommended it for relieving depression and food cravings and normalizing sleep without side effects. Many people found that their symptoms were eliminated permanently after only a few months of L-tryptophan use.
In 1989 a series of bad batches of L-tryptophan, which killed forty people and made many more very sick, prompted the Food and Drug Administration (FDA) to stop all U.S. sales. One Japanese company, Showa Denko, had produced all of these batches, which, it was found, were contaminated because they had eliminated three filter systems that they'd been using for years?just why they chose to take away these safety filters is a question that remains unanswered. Showa Denko has never made tryptophan again. Despite evidence that no other manufacturer has ever made a problem batch, the FDA recommended for years that L-tryptophan not be used as a supplement. (Interestingly, they have made no effort to stop the sale of infant formulas, most of which contain added L-tryptophan.)
With L-tryptophan unavailable, drugs like Prozac, Zoloft and Redux have become our primary tools for combating the crippling symptoms of low serotonin. Unfortunately, these drugs provide only temporary and incomplete benefits, and often have uncomfortable or dangerous side effects. Fortunately, in 1996, many compounding pharmacies began providing L-tryptophan again, by physician prescription, and a new version of tryptophan called 5HTP (5-hydroxytryptophan) became available over the counter in 1998 without FDA opposition. In 2000, Lidtke Technologies Corporation of Phoenix, Arizona, made L-tryptophan available through health professionals without prescription. Look for other supplement suppliers to follow suit, as the FDA has never formally banned the sale of this essential amino acid.
Whatever mood-enhancing brain chemicals you have in short supply, they can be replenished quickly, easily and safely.
Tryptophan Depletion:The Path to Depression, Low Self-Esteem, Obsession and Eating Disorders
Serotonin, perhaps the most well known of the brain's four key mood regulators, is made from the amino acid L-tryptophan. Because few foods contain high amounts of tryptophan, it is one of the first nutrients that you can lose when you start dieting. A new study shows that serotonin levels can drop too low within seven hours of tryptophan depletion. Let's follow this single essential protein (there are nine altogether) as it becomes more and more deeply depleted by dieting, to see how decreased levels of even one brain nutrient might turn you toward depression, compulsive eating, bulimia or anorexia.
In his best seller, Listening to Prozac, Peter Kramer, M.D., explains that when our serotonin levels drop, so do our feelings of self-esteem, regardless of our actual circumstances or accomplishments. These feelings can easily be the result of not eating the protein foods that keep serotonin levels high. As their serotonin-dependent self-esteem drops, girls tend to diet even more vigorously. ?If I get thin enough, I'll feel good about myself again!? Tragically, they don't know that they will never be thin enough to satisfy their starving minds. Extreme dieting is actually the worst way to try to raise self-esteem because the brain can only deteriorate further and become more self-critical as it starves. More and more dieters worldwide are experiencing this miserable side effect of weight reduction on the brain.
When tryptophan deficiency causes serotonin levels to drop, you may become obsessed by thoughts you can't turn off or behaviors you can't stop. Once this rigid behavior pattern emerges in the course of dieting, the predisposition to eating disorders is complete. Just as some low-serotonin obsessive-compulsives wash their hands fifty times a day, some young dieters may begin to practice a constant, involuntary vigilance regarding food and the perfect body. They become obsessed with calorie counting, with how ugly they are, and with how to eat less and less. As they eat less, their serotonin levels fall farther, increasing dieters' obsession with undereating. As their zinc and B vitamin levels drop low as well, their appetite is lost. This can be the perfect biochemical setup for anorexia.
What so many therapists and others have observed as the central issue of ?control? in anorexia often comes down to this: just as vitamin C deficiency (scurvy) results in an outbreak of red spots, do does tryptophan (and serotonin) deficiency result in an outbreak of the obsessive-compulsive behavior that we call ?control.? There may be psychological elements in the picture, too, but a low-serotonin brain is ill equipped to resolve them.
Excerpted from The Diet Cure, by Julia Ross, www.dietcure.com. We extend our grateful acknowledgement to Julia Ross for permission to reprint.
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