GABA'S ROLE IN THE BRAIN
GABA is made in brain cells from glutamate, and functions as an inhibitory neurotransmitter ? meaning that it blocks nerve impulses. Glutamate acts as an excitatory neurotransmitter and when bound to adjacent cells encourages them to ?fire? and send a nerve impulse. GABA does the opposite and tells the adjoining cells not to ?fire?, not to send an impulse.
Without GABA, nerve cells fire too often and too easily. Anxiety disorders such as panic attacks, seizure disorders, and numerous other conditions including addiction, headaches, Parkinson's syndrome, and cognitive impairment are all related to low GABA activity. GABA hinders the transmission of nerve impulses from one neuron to another. It has a calming or quieting influence. A good example to help understand this effect is caffeine. Caffeine inhibits GABA release. The less GABA, the more nerve transmissions occur. Think what too much coffee feels like: that is the sensation of glutamate without enough GABA.
Suz:nutso:
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