Morning, I know that some of the other articles I've referred or posted have provided some information on acetaldehyde but I wanted to post the symptoms and how to combat them to create recovery.
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Acetaldehyde promotes addiction to toxic substances. Perhaps one of the most surprising ways AH may alter normal brain function is due to its tendency to combine in the brain with two key neurotransmitters, dopamine and serotonin.(20) When AH and dopamine combine, they form a condensation product called salsolinol. When AH combines with serotonin, another product called beta-carboline is formed. Salsolinol and beta-carboline are two of a group of inter-related and interconvertible compounds called tetrahydro-isoquinolines.(20) The various tetrahydroisoquinolines which both animal and human research have shown to occur at high levels in the brains, spinal fluids, and urine of chronic alcoholics are closely related in structure, function, and addictive power to opiates! (20) Successfully detoxifying alcoholics have been shown to excrete especially high levels of these opiate-like chemicals in their urine. (20) Thus, these AH-generated, opiate-like biochemicals may at least partly explain why alcoholics are
so addicted to alcohol, cigarette smokers to cigarettes, and Candida-sufferers to sugar, since all three of these conditions promote chronic excessive body AH levels.20 And, like opiates, these tetrahydroisoquinoline biochemicals would tend to promote lethargy, mental cloudiness and fogginess, depression, apathy, inability to concentrate, etc. These, of course, are symptoms common to both alcoholism and Candidiasis, the two conditions which would tend to generate the highest chronic AH levels in the body. (20) The difficulties discussed above that are caused by chronic AH toxicity should indicate to the reader that AH has a significant ability to compromise brain function. A partial summary of AHs damaging effects on brain function includes the following:
Impaired memory
Decreased ability to concentrate (brain fog)
Depression
Slowed reflexes
Lethargy and apathy
Heightened irritability
Decreased mental energy
Increased anxiety and panic reactions
Decreased sensory acuity
Increased tendency to alcohol, sugar, and cigarette addiction
Decreased sex drive
Increased PMS and breast swelling/tenderness in women.
How Nutrition Can Help
Fortunately, applied nutrition science offers some protection against chronic AH toxicity, even when it is not possible to completely avoid the four main offenders that promote AH in our bodies: alcohol, Candida, cigarettes, and heavy auto exhaust. Herbert Sprince, M.D. and his colleagues published many articles in the 1970s detailing the results of their experiments which used various nutrients to protect rats from AH poisoning. Sprince fed a control group of rats an amount of AH sufficient to kill 90% of the control group in 72 hours. The experimental group of rats given the same amount of AH were also given various nutrients, either singly or in combination, that might detoxify the AH. After 72 hours, the death rate for rats given large oral doses of Vitamin C was only 27% (vs 90% in controls), 20% for rats given the sulfur amino acid L-cysteine, 10% for rats receiving Vitamin B1, and an amazing 0% for rats protected by N-acetyl cysteine or lipoic acid. A lower dose combination of C, B1 and either L-Cysteine or N-acetyl cysteine also gave near 0% death rates! (7) But, the nutrient doses Sprince administered were rather gigantic compared to RDA levels of nutrients, being equivalent to multi-gram doses for humans. Fortunately, however, most people are not subjected to such high levels of AH, so lower doses of these nutrients would
doubtless provide significant AH-detoxifying power when used on a long-term basis.
John Cleary, M.D. has published papers summarizing many doctors and researchers successful use of niacin (Vitamin B3) and zinc in alcohol and AH detoxification. (1) Since the enzymes that break down alcohol and AH are both B3 (11) and zinc-activated, (12) this provides an obvious rationale for their protective use in chronic alcohol/AH
toxicity situations. Finally, because chronic high tissue levels of AH impair the normal process of recycling the active form of B3 (NAD) for continual re-use, (1) it is obvious why normal dietary levels of B3 might be insufficient to provide optimal brain B3 levels in chronic AH toxicity situations.
Posted with permission. The full article is at www.vrp.com/art/598.asp?c...s&p=no&s=0
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Acetaldehyde promotes addiction to toxic substances. Perhaps one of the most surprising ways AH may alter normal brain function is due to its tendency to combine in the brain with two key neurotransmitters, dopamine and serotonin.(20) When AH and dopamine combine, they form a condensation product called salsolinol. When AH combines with serotonin, another product called beta-carboline is formed. Salsolinol and beta-carboline are two of a group of inter-related and interconvertible compounds called tetrahydro-isoquinolines.(20) The various tetrahydroisoquinolines which both animal and human research have shown to occur at high levels in the brains, spinal fluids, and urine of chronic alcoholics are closely related in structure, function, and addictive power to opiates! (20) Successfully detoxifying alcoholics have been shown to excrete especially high levels of these opiate-like chemicals in their urine. (20) Thus, these AH-generated, opiate-like biochemicals may at least partly explain why alcoholics are
so addicted to alcohol, cigarette smokers to cigarettes, and Candida-sufferers to sugar, since all three of these conditions promote chronic excessive body AH levels.20 And, like opiates, these tetrahydroisoquinoline biochemicals would tend to promote lethargy, mental cloudiness and fogginess, depression, apathy, inability to concentrate, etc. These, of course, are symptoms common to both alcoholism and Candidiasis, the two conditions which would tend to generate the highest chronic AH levels in the body. (20) The difficulties discussed above that are caused by chronic AH toxicity should indicate to the reader that AH has a significant ability to compromise brain function. A partial summary of AHs damaging effects on brain function includes the following:
Impaired memory
Decreased ability to concentrate (brain fog)
Depression
Slowed reflexes
Lethargy and apathy
Heightened irritability
Decreased mental energy
Increased anxiety and panic reactions
Decreased sensory acuity
Increased tendency to alcohol, sugar, and cigarette addiction
Decreased sex drive
Increased PMS and breast swelling/tenderness in women.
How Nutrition Can Help
Fortunately, applied nutrition science offers some protection against chronic AH toxicity, even when it is not possible to completely avoid the four main offenders that promote AH in our bodies: alcohol, Candida, cigarettes, and heavy auto exhaust. Herbert Sprince, M.D. and his colleagues published many articles in the 1970s detailing the results of their experiments which used various nutrients to protect rats from AH poisoning. Sprince fed a control group of rats an amount of AH sufficient to kill 90% of the control group in 72 hours. The experimental group of rats given the same amount of AH were also given various nutrients, either singly or in combination, that might detoxify the AH. After 72 hours, the death rate for rats given large oral doses of Vitamin C was only 27% (vs 90% in controls), 20% for rats given the sulfur amino acid L-cysteine, 10% for rats receiving Vitamin B1, and an amazing 0% for rats protected by N-acetyl cysteine or lipoic acid. A lower dose combination of C, B1 and either L-Cysteine or N-acetyl cysteine also gave near 0% death rates! (7) But, the nutrient doses Sprince administered were rather gigantic compared to RDA levels of nutrients, being equivalent to multi-gram doses for humans. Fortunately, however, most people are not subjected to such high levels of AH, so lower doses of these nutrients would
doubtless provide significant AH-detoxifying power when used on a long-term basis.
John Cleary, M.D. has published papers summarizing many doctors and researchers successful use of niacin (Vitamin B3) and zinc in alcohol and AH detoxification. (1) Since the enzymes that break down alcohol and AH are both B3 (11) and zinc-activated, (12) this provides an obvious rationale for their protective use in chronic alcohol/AH
toxicity situations. Finally, because chronic high tissue levels of AH impair the normal process of recycling the active form of B3 (NAD) for continual re-use, (1) it is obvious why normal dietary levels of B3 might be insufficient to provide optimal brain B3 levels in chronic AH toxicity situations.
Posted with permission. The full article is at www.vrp.com/art/598.asp?c...s&p=no&s=0