Benefits of L-Glutamine

[RedThread12]

Benefits of L-Glutamine

Bump for HaveFaith.

[PhoenixRising]

Benefits of L-Glutamine

Why aren't you supposed to take it past 3pm?

[craving]

Benefits of L-Glutamine

PhoenixRising;943484 wrote: Why aren't you supposed to take it past 3pm?

never heard of this before. I took it also before going to sleep. No problems whatsoever

[RedThread12]

Benefits of L-Glutamine

Bump for The Time Is Now.

[shaz]

Benefits of L-Glutamine

That's huge information..! Thanks a lot Dee for such an information about L-GLUTAMINE. Its takes a lot of time to surf about the glutamine but because of you I had every thing as a bulk in this post. Once again thanks for sharing such an useful information.

[Bruunhilde]

Benefits of L-Glutamine

Is Glutamine Supplementation Helpful or Harmful? 5/1/04

I don't like being a buzz-kill, but I think this needs to be considered before dumping huge amounts of an isolated amino that is controversial into the body. It may or may not be worse than drinking too much alcohol but its certainly worse than eating a little too much junk food, if that's what you're using L-glut for.

Excerpt:
In two recent studies it was found that the amount of glutamine in the brain could predict the brain damage seen both in pediatric brain injuries and brain damage secondary to seizures. Adding large amounts of glutamine to the diet increases significantly brain levels of glutamine and, hence, glutamate. Another study found that by adding glutamine to the diet of animals exposed to another powerful excitotoxin called quinolinic acid, brain cell damage was increased significantly. Quinolinic acid is known to accumulate in the brain in most cases of viral brain infection as seen with HIV dementia and viral encephalitis.
Glutamine and Liver Toxicity

Individuals with liver toxicity tend to accumulate ammonia in their blood and brain. Until recently, it was assumed that it was the ammonia that caused liver disease-associated brain injury and that glutamine was protective.
Newer studies indicate that actually it is the glutamine that is causing the brain?s injury. Increasing glutamine in the diet would significantly aggravate this damage.
Free Radicals in the Brain

Glutamine accumulation has also been found in Alzheimer?s disease, Huntington?s disease and high levels of brain glutamine have been associated with a worse prognosis in Lou Gehrig?s disease. Likewise, recent studies have shown that high brain glutamine levels increase brain levels of free radicals and impair the ability of brain mitochondria to produce energy. When the brain produces low energy, excitotoxins, such as glutamate, become even more toxic. It has been shown that the reason for glutamine toxicity under these conditions is because it is converted to the excitotoxin--glutamate.
Glutamine and Multiple Sclerosis

Of particular concern is the finding that people with multiple sclerosis have increased levels of the enzyme glutaminase (the enzyme that converts glutamine into glutamate) in areas of nerve fiber damage. High levels of glutamine in the diet would increase glutamate levels near these injured areas magnifying the damage. It has been shown that excitotoxicity plays a major role in multiple sclerosis by destroying the cells (oligodendrocytes) that produce myelin.
Glutamine and Pregnant Women

Another area of concern would be pregnant women. Glutamine passes through the placenta and may actually be concentrated in the baby?s blood, producing very high levels. Glutamate plays a major role in the development of the baby?s brain. Excess glutamate has been shown to cause significant impairment of brain development in babies and can lead to mental retardation.
When to Use Glutamine

The major use for high-dose glutamine would be to repair gastrointestinal injury. In such cases, I would recommend short-term use only. Those with a history of the following conditions should avoid glutamine, even for short-term use:[*]StrokeNeurodegenerative diseasePregnancy[*]Malignancy[*]Recent vaccinations[*]ADHD[*]HypoglycemiaAutismMultiple sclerosisOther neurological disordersGlutamine has recently been shown to produce extreme hypoglycemia, even more so than leucine, which is known to produce fatal hypoglycemia in infants.
The reason Chinese Restaurant Syndrome is not seen with glutamine challenge is that the glutamate receptors in the lungs and esophagus are stimulated by glutamate, not glutamine. The glutamine must be converted first and this occurs primarily in the brain.
The only safe situation for glutamine use is in the vigorous athlete. Glutamine is used as a muscle fuel, so that vigorous exercise will consume most of the glutamine before it can accumulate in the brain. I would still avoid long-term use in high doses. I would caution readers to avoid excess glutamine, especially in the above named conditions and situations.

[ifulovelife2]

Benefits of L-Glutamine

Whaaaaat???? So now L-Glut is bad for you?????!!!!?? Geez people, I wish you'd make your minds up. This is all so confusing for a mere simpleton such as myself. What next, rancid tea that's been left so a disgusting mould grows atop it is good for you? Lol, obviously not. That was just a joke.

[Bruunhilde]

Benefits of L-Glutamine

:goodjob:

[MWOLady]

Benefits of L-Glutamine

But wait, those warnings seem to be for people serious health problems already:

The major use for high-dose glutamine would be to repair gastrointestinal injury. In such cases, I would recommend short-term use only. Those with a history of the following conditions should avoid glutamine, even for short-term use:
Stroke
Neurodegenerative disease
Pregnancy
Malignancy
Recent vaccinations
ADHD
Hypoglycemia
Autism
Multiple sclerosis
Other neurological disorders

So my take on this is that very high doses of anything are not good. But surely most of this kind of research is done on rats for starters, and usually are given in crazy high doses. L-glut has had a good history in athletes. And in otherwise healthy people I don't think it would be still on the shelves if there was real danger. Or there would be warnings on the label etc. no?

I would like to hear reactions to this kind of warning from any of you out there who do use it for cravings for alcohol or carbs. Will you lower your dose? Will you stop taking it? I'm finding it so helpful I don't want to be scared off unnecessarily!!!!!

[beatle]

Benefits of L-Glutamine

yeah, don't be scared off. See my post on your thread in Meds.

[beatle]

Benefits of L-Glutamine

Also, click on the link and read the whole article (not just what Bruun cut and pasted and bolded). It presents a rather less scary take on L-glut. And notice that it is a contrasting opinion to what most doctors/researchers think.

According to all my research, up to 20 grms a day is not dangerous -- and over 5mg/day is advisable.

[MWOLady]

Benefits of L-Glutamine

great, thanks. It's so hard to put things in perspective when we all toss research around. Could it be we're so anxious to get well??? I know that 5HTP seems to calm me and L-Glut seems to stop my cravings for booze and carbs. As I intend them as a "help" with getting some mega AF days under my belt I think I'll continue for as long as that takes - a few months???? then see about maybe slacking off a bit.

I've got a persistent headache today and I don't know if it was the wine I drank last night, my usual migraine, or too many amino acids yesterday, or stress release from the stress of the dinner party last night...oh well, today will be an AF day - the first of many I hope - so headache or not it IS A GREAT DAY!

[beatle]

Benefits of L-Glutamine

I suggest you get Seven Weeks to Sobriety and follow that protocol for aminos (other supplements, too). It includes follow-on weeks as you rack up the AF days -- when and how much to reduce the megadoses you need in the first weeks when quitting and after quitting. It's all mapped out for you, and it explains what each one does. (I tailor make it for my own purposes, but it's a great starting point.)

Note: You don't need to buy the supps from the Bio-Recovery brand (that is part of the program), and in fact I don't (especially because they are all gelatin capsules and I prefer Vcaps).

I get all my supplements separately, diff brands for diff supps. I research them all first and then pick what seems best suited for me, and then try diff brands until I find what I like best.

The main thing that is wrong in Seven Weeks (maybe this has been revised since the original version) is that it says to take 5HTP instead of L-tryp for reasons that are erroneous; L-tryp is far better, but I won't get into it now.

[MWOLady]

Benefits of L-Glutamine

thanks for the suggestions. I can't get L-tryp here so have to settle for the 5HTP. I do find it mellows me out pdq though, so I'm happy so far.

And hey, go into as much as you like about your impressions, thoughts, insights, knowledge!!! I'm a sponge right now and need all the help I can get!!

[Bruunhilde]

Benefits of L-Glutamine

beatle;1237130 wrote: Also, click on the link and read the whole article (not just what Bruun cut and pasted and bolded). It presents a rather less scary take on L-glut. And notice that it is a contrasting opinion to what most doctors/researchers think.

According to all my research, up to 20 grms a day is not dangerous -- and over 5mg/day is advisable.

Lovely to see you online beatle.

Note I did not bold that portion, when I cut and pasted it, it self bolded. I was not trying to scare anyone unnecessarily.

Also, your sources quoted are older research-based than the two doctors I quoted. I have always held Joan Larson (Seven Weeks) and Julia Ross in highest esteem, however, all research becomes dated.

I was quoting the most recent studies and they do quote glutamine toxicity in the brain as a common denominator in many chronic diseases. I've stopped taking it on a regular basis but keep it on hand for GI repair.