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    Healing the brain and body through supplements -- everything explained

    This is a very long article, but if you are interested in healing your brain and body, this spells it all out for you. And even though it's long, it's REALLY interesting if you are interested in how your alcoholic brain and body work, and how to heal it with supplements (vitamins, minerals, amino acids). This article is just one in a series about alcoholic brains and bodies. You can google for other articles in this series if you want to read more. This was posted in the Research section, but I thought it also belonged here.

    I'm really interested to hear what people think...


    Alcoholism, Part 3 -- Fixing the Brain — 2
    By David Gersten, M.D.
    Last month we looked at the devastating impact that alcohol has on the brain. Every important neurotransmitter system is impaired by alcohol. Alcoholism brings with it three major toxins, namely: Alcohol (ethanol), acetaldehyde (a primary bre akdown product of alcohol), and tetra-hydroisoquinolines (THIQs). Acetaldehyde combines with neurotransmitters to make THIQs, which are addictive, morphine-like compounds. These three toxins act as pseudo-neurotransmitters by binding to neurotransmitter receptor sites.
    When the alcoholic is drinking, his brain “thinks” there is enough serotonin, norepinephrine, dopamine, endorphins, acetylcholine, and GABA. But the brain has been tricked by alcohol and its two related toxins. As soon as the alcoholic stops drinking, his brain truly experiences serious deprivation of all major neurotransmitters. He resumes drinking because alcohol makes the brain “believe,” once again, that it has plenty of GABA, serotonin, and the other major neurotransmitters. In the last article, we went into detail about the process by which the brain is damaged, and reviewed the theory that disorders of GABA (gamma-amino-butyric-acid) may be the single most important factor in alcoholism.
    In this article, the focus will be on specific neuro-cognitive problems caused by alcoholism, and how we can treat those problems in a natural way. Before exploring these symptoms and problems, let me clear up a very important and controversial issue surrounding alcoholism.
    In order to move toward an understanding of how to cure alcoholism, let's start by addressing two important issues that are frequently misunderstood. First, let's talk about the alcoholic personality, the type of makeup that predisposes one to become alcoholic. Understanding this makeup will make it easier for you to know which kind of psychotherapy or support system will best suit you.
    Here is the answer. In 1984 a study of 650 young men showed that there was no evidence whatsoever that there is an “alcoholic personality.” So, folks you can throw out the notion that your mother, father, your abuse, neglect, or stress caused your problem with drinking. Alcoholism is not a psychiatric disorder and does not belong in the DSM-IV, the psychiatric bible of diagnosis.
    Secondly, you need to understand that support systems, including Alcoholics Anonymous (AA), according to a great deal of research, do not have better than a 5 percent cure rate. Mind you, I refer my alcoholic patients to AA. AA was never intended as a treatment modality. It is support and is profoundly helpful.
    But alcoholism is a physical disease. You cannot cure diabetes or cancer through support groups or psychotherapy, nor can you cure alcoholism through such support. I also don't buy into the nearly universal belief that alcoholism is an incurable disease.
    The point of this tongue-in-cheek discussion of the “Alcoholic Personality” is to help you finally set aside such a notion. There is not a “Diabetic Personality” or an “Arthritic Personality.” Similarly, alcoholism is a disorder of severely disturbed biochemistry. There is metabolic chaos from head to toe. In this article, we continue to examine and repair the metabolic chaos within the brain and nervous system that we began to heal in the last article.
    Treating Specific Neuro-Cognitive Problems
    Every neuro-cognitive, psychological, or mental-emotional problem is associated with specific neurotransmitter problems. Here is how you can address each of these major symptoms associated with alcoholism.
    Anxiety and Insomnia
    44% of alcoholics suffer from anxiety. Anxiety and sleep disorders are closely related. Take GABA for anxiety. Serotonin is the main neurotransmitter that induces sleep. The amino acid L-tryptophan is the precursor to serotonin, so supplementation with L-tryptophan or 5-HTP (5-hydroxy-tryptophan) will help with sleep and anxiety. If you ever blacked out due to drinking, you have a tryptophan deficiency. Inositol, a B vitamin helps regulate serotonin and treats anxiety and panic disorder. You will also want to take P-5-P (pyridoxal-5-phosphate, the active form of Vitamin B-6), for L-tryptophan requires P-5-P to get converted into serotonin. Vitamin B-3 (niacin or niacinamide) helps with serotonin chemistry. Niacin can cause a brief but uncomfortable skin flush, but niacinamide (another form of B-3) won't do that. Bill Wilson, the founder of Alcoholics Anonymous, became quite interested in nutritional approaches to treating alcoholism. In one study of 30 patients treated with Vitamin B-3, 20 were cured of all their symptoms in approximately two months. Bill Wilson was at the forefront of Orthomolecular Medicine. While his first huge contribution, AA, became widely accepted, the medical establishment did not support his claims about niacin, and so he continued his orthomolecular research outside of the mainstream.
    Tremors
    The amino acid, taurine, stabilizes nerve tissue, decreasing tremors as well as the risk of seizures. In addition, take calcium, magnesium, and B Complex. The amino acids, L-glycine and taurine, both enhance alpha brain waves, which are calming. So consider these two for tremors as well as anxiety.
    Depression
    At least 40% of alcoholics are affected by depression. People often blame their depression on what alcohol has done to their performance at work, social life, and marriage, not understanding that they have profound neurotransmitter problems. The two most important neurotransmitters involved in mood are serotonin and norepinephrine. We've already talked about the use of L-tryptophan to increase serotonin levels. This is what the SSRI anti-depressants do (drugs like Paxil and Zoloft). They increase serotonin levels. At least half of depressed people suffer from a norepinephrine depletion and not serotonin depletion, although many alcoholics have both of these “anti-depressant” neurotransmitters depleted.
    The amino acid L-tyrosine is the precursor to norepinephrine. Like L-tryptophan, L-tyrosine must be taken with P-5-P in order to get converted into its end product, namely norepinephrine. Both L-tyrosine and L-tryptophan should be taken away from meals and from other amino acids in order to get into the brain more readily.
    Omega-6 Essential Fatty Acid Defect
    Amino acids are not the only nutrients involved in brain chemistry. In alcoholics, there is a genetic defect in handling the omega-6 fatty acid gamma-linolenic acid (GLA), which converts into prostaglandin 1 (PGE1) in the brain. Orientals lack this genetic defect and, as a result, have an incredibly low incidence of alcoholism.
    Due to the genetic defect, the ability to produce PGE1 drops in the alcoholic brain. PGE1 is very much involved in mood. Alcohol helps the brain produce PGE1, by taking whatever meager supply of GLA that is present and converting it into PGE1. Over time, GLA and PGE1 drop. Because alcohol can mimic PGE1, the alcoholic drinks because his brain is asking for more PGE1, and so he succumbs to what his brain is demanding.
    By supplementing your diet with GLA, you can treat the depression caused by GLA and PGE1 deficiency. If this happens to be your problem, GLA is a wonder nutrient.
    Gastro-Intestinal (GI) Tract and Brain
    While this is a complex subject, which must wait until next month for deeper analysis, for now I want to mention that alcohol damages the lining of the GI tract. Without a healthy GI tract, it is impossible to get an adequate, balanced supply of the vitamins, minerals, fats, and amino acids required to produce neurotransmitters and to maintain good overall brain health. The L-glutamine you will take to increase GABA levels in your brain is also extremely helpful in restoring intestinal health.
    Consider this: If you were to open up the GI tract, it would take up the space of two tennis courts. It is a huge organ with five major functions, namely: 1) absorbing nutrients, 2) keeping toxins out of the body, 3) manufacturing neurotransmitters, 4) acting as the first line of defense of the immune system, and 5) removing waste. The first four GI functions are impaired in alcoholism, and these four affect the brain for better or for worse. Few people know that the GI tract is like a second brain in that it produces huge amounts of neurotransmitters. It is also the largest part of our immune system. Ultimately the alcoholic will fully recover when his brain and GI tract have fully recovered.
    The liver, part of the digestive process, is often damaged in alcoholism. All nutrients absorbed through the GI tract pass through the liver. An impaired liver gives rise to poorly assimilated nutrients. Start taking the herb Sylamarin to begin liver repair.
    Vitamins and Minerals
    B vitamins, all of them, are important for healthy neurotransmitter function. Alcohol destroys B vitamins, so start supplementing with a good multiple B vitamin right away. B vitamins cannot be stored in the body, so they must be ingested and absorbed on a daily basis.
    Alcohol inhibits fat absorption, impairing absorption of the fat-soluble vitamins: A, D, E, and K, all of which are involved in wound healing.
    Calcium and magnesium help to calm the nervous system, decrease anxiety, improve sleep, and reduce withdrawal symptoms. These minerals stabilize the cell membrane of neurons, or nerve cells.
    The mineral, manganese, is needed for proper functioning of the B vitamins and also helps stabilize blood sugar.
    Amino Acids
    While each section of this article has discussed amino acids, as they relate to a particular symptom, it is important to now look at them as a whole. Amino acids are called the building blocks of life. The main purpose of DNA is to take amino acids and use them to build protein, neurotransmitters, hormones, enzymes and other tissue structures. Each gene in our DNA codes for one particular protein.
    There are 9 “Essential” amino acids, which means that we must ingest these from food:
    Arginine, Histidine, Methionine, Threonine, Valine, Isoleucine, Lysine, Phenylalanine, Tryptophan, and Leucine.
    The remaining 11 major amino acids are either “Non-Essential,” meaning our body can make these from other amino acids, and “Conditionally Essential.” Conditionally essential amino acids are those that our bodies ordinarily can make but due to a variety of stresses and illnesses, our bodies stop making these amino acids…at which point they become “Essential” and we must either ingest foods with those amino acids or take nutritional supplements. This group of amino acids includes:
    Alanine, Asparagine, Aspartic Acid, Cysteine, Glutamine, Glutamic Acid, Glycine, Proline, Serine, Taurine, and Tyrosine.
    The fact is that both “Non-Essential” and “Conditionally-Essential” amino acids can become “Essential” when we are stressed or sick. In other words, our bodies stop making these.
    Amino acids participate in every chemical reaction in the body, but let's focus on how they are involved with brain chemistry. Ordinarily, the letter “L” precedes the name of an amino acid, but I will skip that formality here. The only regularly used amino acid with a different “form” is DL-phenylalanine, which is used to alleviate pain.
    Tyrosine is the precursor to the neurotransmitters dopamine and norepinephrine. If you are deficient in norepinephrine, you may feel depressed, anxious, sleep poorly, and have poor concentration, poor memory, and a host of other cognitive problems. In general, supplementation with tyrosine will bring norepinephrine levels back to normal and will alleviate some or all of these symptoms. Before taking tyrosine, or going on an amino acid program, lab work should be done for amino acids, and thyroid function should be checked, since one of tyrosine's functions is to produce thyroid hormone, or thyroxin. In my opinion, the best laboratories for analyzing amino acids are Great Smokies Diagnostic Labs, MetaMetrix, and Doctor's Data. The best amino acid tests have 41 sub-tests, which provides an enormous amount of useful information.
    Dopamine, also made from tyrosine, is a “feel-good” neurotransmitter. The dopamine receptor site is where cocaine and amphetamines work. Dopamine mediates the “feel-good” of sexual orgasm. If you have too little dopamine, you are not likely to feel cheerful. If you have too much, you are likely to experience anxiety, fear, or paranoia. So, dopamine needs to be kept in careful balance. More is not necessarily better.
    Tryptophan is the precursor to serotonin. Low serotonin levels will lead to depression, insomnia, and some cognitive impairment.
    Taurine is an amino acid that is a direct neurotransmitter, stabilizing nerve cells (neurons) as well as heart cells. In alcoholism, it is useful in stabilizing an agitated brain, and in helping to prevent tremors and seizures.
    Glutamine is the precursor to another amino acid, GABA. GABA is another feel-good neurotransmitter and is the most calming of all neurotransmitters. Alcohol toxins dramatically impair GABA and GABA-receptor sites. As mentioned previously, GABA may be the key to understanding alcoholism.
    Like GABA, glycine is an inhibitory neurotransmitter, producing a calming effect.
    Other amino acids play a role in brain chemistry, but the ones you've just read about are the most important. Amino acid chemistry is very complicated. It took me ten years of study and amino-acid testing before I began to get a handle on it. Don't just play around with amino acids. Look carefully at the recommendations in this article and in the last one, and remember that, while taking tyrosine (which will usually lift depression and brain fog), don't forget to focus on healing problems with digestion. If you have a healthy GI tract, you will be able to absorb most of the amino acids you need from a healthy diet.
    A final word about amino acid therapy. A multi-amino acid is going to help alcoholics. These contain all the essential amino acids in relatively high doses, as well as the non-essential amino acids. Some multi-amino acids are formulated to assist with problems of muscle weakness. Others are formulated to help people with blood sugar problems. Whatever you do, do not buy amino acids from health food stores. These aminos are usually made in India and China, can be contaminated with impurities such as arsenic, may not have the amino acids in the capsule as promised, and may have nutrients in the capsule that are not supposed to be there. Buy nutraceutical grade amino acids. The Internet is the best and easiest place to find nutra-ceutical grade amino acids. Nutraceutical brands include Montiff, Pure Encapsulation, Thorne, and Allergy Research, to name a few.
    This article and the last one have given you a strong dose of knowledge about alcoholism and brain chemistry. In the next issue, we will look at non-brain problems of alcoholism, including: hypoglycemia, candidiasis, allergy, and adrenal exhaustion.
    David Gersten, M.D. practices nutritional medicine and psychiatry out of his Encinitas office and can be reached at 760-633-3063. Please feel free to access 1,000 on-line pages about holistic health, amino acids, and nutritional therapy at amino acid power --> Home.
    Your time is limited, so don't waste it living someone else's life... And most important, have the courage to follow your heart and intuition. They somehow already know what you truly want to become. Everything else is secondary.

    Steve Jobs, Stanford Commencement Adress, 2005

    #2
    Healing the brain and body through supplements -- everything explained

    p.s. If anyone who reads this thinks it is good or great, please rate it with stars (hopefully 5 stars), as this will get more attention by readers, and I think this is really important information for healing the brain without drugs.
    Your time is limited, so don't waste it living someone else's life... And most important, have the courage to follow your heart and intuition. They somehow already know what you truly want to become. Everything else is secondary.

    Steve Jobs, Stanford Commencement Adress, 2005

    Comment


      #3
      Healing the brain and body through supplements -- everything explained

      Thanks Beatle for posting this! Some great info here!
      _______________
      NF since June 1, 2008
      AF since September 28, 2008
      DrunkFree since June 1, 2008
      _____________
      :wings: In memory of MDbiker aka Bear.
      5/4/2010 In loving memory of MaryAnne. I pray you've found peace my friend.
      _______________
      The will of God will never take you where the Grace of God will not protect you.ray:

      Comment


        #4
        Healing the brain and body through supplements -- everything explained

        Awesome article Beatle, thanks for posting it. I have studied the concepts of recovery with natural therapies for quite some time and currently taking almost all of the recommended nutrients that this article discusses. I have been al free for some time now (Into my fifth months) and take no prescribed meds. My al cravings are nil and my energy levels and mood are stable and much better than ever. I really feel that we need to put a lot more emphasis of biochemical repair if we are to be able to enjoyed sustained sobriety. Onwards and upwards Saff
        I am a part of the family of humanity. Not one person on this earth is a stranger to me. Rev. Ted Noffs

        Comment


          #5
          Healing the brain and body through supplements -- everything explained

          p.;s. Beatle how do we go about rating this???
          I am a part of the family of humanity. Not one person on this earth is a stranger to me. Rev. Ted Noffs

          Comment


            #6
            Healing the brain and body through supplements -- everything explained

            high fives Beatle, love it
            nosce te ipsum
            (Know Thyself)

            Comment


              #7
              Healing the brain and body through supplements -- everything explained

              Beatle,

              I LOVE this type of info. I am particularly interested in GABA and have been taking so much GABA CALM I was afraid I was going to OD on it. It is good stuff but I don't want to take too much so that my little brain quits producing it on its own. I am on Day 26 of AF now and feel pretty good. The info you posted makes me feel so very hopeful and optimistic about recovery. And I like the info the article referenced on AA. Multiple approaches are a good thing.

              I gain so much knowledge from this site. Thanks to all.

              Comment


                #8
                Healing the brain and body through supplements -- everything explained

                Lucky, huge congrats on the AF time! way to go.

                I just got a fascinating article from Mercola on fighting Alzheimer's with diet. I'll post it on the Paleo since it's related to that dietary lifestyle and so I don't totally hijack this one
                nosce te ipsum
                (Know Thyself)

                Comment


                  #9
                  Healing the brain and body through supplements -- everything explained

                  Excellent beatle!

                  luCKy... kudos!!
                  sigpic
                  Thoughts become things..... choose the good ones. ~TUT

                  Comment


                    #10
                    Healing the brain and body through supplements -- everything explained

                    this reminds me of why I take whey protein concentrate (not isolate) every day now as part of my daily ritual.

                    around my 1st year anniversary at MWO I became very interested in amino therapy and went to the health food store with a ton of notes on various things I needed. I was asking a bunch of questions to the staff there and they were very helpful. I made a comment about how this was going to cost about 250.00 to get everything I needed and the lady said: look....let me help you get a sh*tload of aminos all in one go, at a good price per serving. I was all ears! surprisingly she led me to the bodybuilding section and handed me a jug of powder and said to read the label. I must say it was an eye opener for sure. a really good quality protein powder (my fav at the moment happens to be the all natural one by Jarrow Formulations) is LOADED with bio-available aminos. now make sure you get one that is independently lab tested for purity and absence of harmful toxins and you're off to a darn good start. I'm convinced from my own experience that this simple daily ritual has provided me a great deal more energy, better sleep and elevation of mood. also my recovery from exercise is very swift.
                    nosce te ipsum
                    (Know Thyself)

                    Comment


                      #11
                      Healing the brain and body through supplements -- everything explained

                      Beatle, I really enjoyed this article. I recently started reading the Books by Kathleen Des Maisons - Potatoes Not Prozak being the most "famous" one. I found it interesting to read this article - it certainly mirrors a lot of what she says in her books. Her premise is that addiction to alcohol, sugar, and certain drugs is based on faulty bio chemistry. The "3 legs of the stool" in her eyes are low seratonin, low beta-endorphin, and unstable blood glucose. Her books address ways to naturally stabilize blood sugar, and raise seratonin and beta endorphin. The "potato" (which is what piqued my curiosity, to be honest) is part of the protocol for getting the L-Tryptophan across the blood-brain barrier. She also points out the need for people like us to supplement the B's. Of course it's impossible to describe all this stuff in a post.

                      I sometimes wonder if she's just a nut job talking about me, another nut job. Articles like this one make me think that we're all not so crazy after all, and make me more motivated to keep forging ahead in the world of potatoes not prozak.

                      DG
                      Sobriety Date = 5/22/08
                      Nicotine Free Date = 2/27/07


                      One day at a time.

                      Comment


                        #12
                        Healing the brain and body through supplements -- everything explained

                        I've just signed up here, and did a search for amino info. Was so glad to read this article as I have been researching aminos in regards to alc withdrawal and maintaining sobriety and bought myself L-Glutamine, GABA, L-Tyrosine and L-Tryptophan a few weeks ago as a result.

                        I cannot take Tryptophan or 5HTP as it makes me wig out completely (felt like coming off a cocaine bender) - and I think that had something to do with having taken Zoloft for about a year a few years back? Needless to say, my experience with Tryptophan was not pleasant and it does not agree with me.

                        Now that the negative aspect of my experiment is out of the way... I absolutely swear by the L-Glutamine, and when I take it I find my cravings are minimalised if not completely nullified. The L-Tyrosine is fantastic to lift my mood and enery levels on some working days (I do not take it on the weekend or if I'm already feeling OK) and the GABA is brilliant for an anxious mind like mine. It works better than valium!

                        I have also been taking Melatonin (2x5mg) on sleepless nights. I find insomnia hits me quite hard when I haven't had a drink.

                        I'm still struggling with the amount I drink when I do allow myself to get my drink on, but I'll get there eventually and these are definitely helping me get control over what has been a daily habit for the last 15 years.

                        A question: does anyone know if there are any adverse effects of taking these supps long-term? I recently had a blood test return elavated liver enzymes and I have read L-Glut is not so kind to the liver. Also, I'm a little concerned with taking GABA too often as I have previously had issues with depression that I would not like to exacerbate by messing about with my chemistry too much.


                        Thanks for posting this info!!!
                        I was made with a heart of stone
                        To be broken
                        With one hard blow
                        I've seen the ocean
                        Break on the shore
                        Come together with no harm done...
                        Jane's Addiction ~ Ocean Size

                        Comment


                          #13
                          Healing the brain and body through supplements -- everything explained

                          Oceansize, big welcome to you!

                          where have you read LGlut is not so good for the liver? I've read several articles espousing it's benefit to hepatic and endocrine function. it's taken in HUGE doses by athletes and there is no published toxic level that I'm aware of, and no limit on how long you can take it. As always I'm keen to learn, so if anyone has anything new on the subject I'd love to see it.

                          Glutamine and Glutamic Acid - Benefits, Sources, Deficiency, Dosage

                          L-Glutamine Side Effects and Glutamine Benefits

                          I'm not so well read on the GABA. I have heard of a seratonin toxicity as a possibility depending on your body's chemistry and how much supplement you take.

                          for me, the biggest relief for anxiety/depression and craving relief comes from a low carbohydrate, hi protein and moderately high fat diet combined with regular exercise. I swear that if everyone were to give that a go for 30 days it would change their life magnificently.
                          nosce te ipsum
                          (Know Thyself)

                          Comment


                            #14
                            Healing the brain and body through supplements -- everything explained

                            Beatle thanks for posting this article, this is something I am very interested in, even though it was a long read, its was well worth taking the time to read it
                            definatly a 5 star rating
                            Lilly

                            Comment


                              #15
                              Healing the brain and body through supplements -- everything explained

                              Determinator;1030316 wrote:

                              where have you read LGlut is not so good for the liver? I've read several articles espousing it's benefit to hepatic and endocrine function. it's taken in HUGE doses by athletes and there is no published toxic level that I'm aware of, and no limit on how long you can take it. As always I'm keen to learn, so if anyone has anything new on the subject I'd love to see it.

                              Determinator, thanks so much for the info! I was trawling about the Net and came across a few forum posts and short articles where people had mentioned elevated liver enzymes due to high dose L-Glutamine usage. Nowhere did I find any scientific evidence that this is a common occurance in normal doses, but with my recent blood test result, I thought I'd ask here in case anyone knew of any associated probs. I'm taking about 3000mg a day (1000mg x 3 doses) which seems to be pretty tame in comparison to some body builder's intakes.

                              Determinator;1030316 wrote:
                              for me, the biggest relief for anxiety/depression and craving relief comes from a low carbohydrate, hi protein and moderately high fat diet combined with regular exercise. I swear that if everyone were to give that a go for 30 days it would change their life magnificently.
                              Any links for the diet you are following? I eat quite well, all things considered, but could definitely use some pointers to improve my diet and ensure I'm eating foods that are benefitting me both physically and mentally. I should probably add that I take B12 and Super B Complex each day also.

                              Thanks again
                              I was made with a heart of stone
                              To be broken
                              With one hard blow
                              I've seen the ocean
                              Break on the shore
                              Come together with no harm done...
                              Jane's Addiction ~ Ocean Size

                              Comment

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