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    #16
    On Serotonin

    Hey Boss, I ran across this study today from Science Daily, it will kick-start your dopamine research:

    New research from Northwestern University's Feinberg School of Medicine has revealed that dopamine strengthens and weakens the two primary circuits in the brain that control our behavior. This provides new insight into why a flood of dopamine can lead to compulsive, addictive behavior and too little dopamaine can leave Parkinson's patients frozen and unable to move.
    "The study shows how dopamine shapes the two main circuits of the brain that control how we choose to act and what happens in these disease states, " said D. James Surmeier, lead author and the Nathan Smith Davis Professor and chair of physiology at the Feinberg School. The paper is published in the August 8 issue of the journal Science.
    These two main brain circuits help us decide whether to act out a desire or not. For example, do you get off the couch and drive to the store for an icy six-pack of beer on a hot summer night, or just lay on the couch?
    One circuit is a "stop" circuit that prevents you from acting on a desire; the other is a "go" circuit that provokes you to action. These circuits are located in the striatum, the region of the brain that translates thoughts into actions.
    In the study, researchers examined the strength of synapses connecting the cerebral cortex, the region of the brain involved in perceptions, feelings and thought, to the striatum, home of the stop and go circuits that select or prevent action.
    Scientists electrically activated the cortical fibers to simulate movement commands and boosted the natural level of dopamine. What happened next surprised them. The cortical synapses connecting to the "go" circuit became stronger and more powerful. At the same time, dopamine weakened the cortical connections in the "stop" circuit.
    "This could be what underlies addiction," Surmeier said. "Dopamine released by drugs leads to abnormal strengthening of the cortical synapses driving the striatal 'go' circuits, while weakening synapses at opposing 'stop' circuits. As a result, when events associated with drug taking – where you took the drug, what you were feeling – occur, there is an uncontrollable drive to go and seek drugs."
    "All of our actions in a healthy brain are balanced by the urge to do something and the urge to stop," Surmeier said. "Our work suggests that it is not just the strengthening of the brain circuits helping select actions that is critical to dopamine's effects, it is the weakening of the connections that enable us to stop as well. "
    wip

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      #17
      On Serotonin

      Wow bossman...this is really interesting. Thanks for all the great info.
      I'm wondering if our seretonin levels out after being AF for a while...what causes the cravings in some who are still doing it one day at a time years latter?
      I remember reading about the mid brain in Trimpy's (sp?) RR book. He called it the beast.
      I personally like the box of little kittens

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        #18
        On Serotonin

        okydoky;378537 wrote:
        I'm wondering if our seretonin levels out after being AF for a while...what causes the cravings in some who are still doing it one day at a time years latter?
        Good question Oky, and I don't know the answer for long term cravings.

        I was wrong to imply that there is one source of cravings too. Alcohol use can flood the body with glucose (blood sugar) causing a temporary sugar high. Used on a long term basis, apparently, can cause your body (muscles) to "crave" the energy boost. I found this out bigtime since I've lost 7 lbs so far in being AF (Day 7 now).

        You also get cravings from "habits", routines that have become ingrained to the point they provide comfort, or discomfort if not followed. All Americans practice a cultural habit of having coffee in the morning, thus reinacting a 300 year old protest over the British tax on tea. It would be discomforting for us to walk in a restaurant and not have them offer it, and in living in a country that did not offer it, we would "crave" it.

        I suspect, for long term cravings, learning about and addressing your body's serotonin levels may help. I'm have on order the book "The serotonin power diet" and they also have a message forum.

        My Community - Index

        Exercise, chocolate and sex will help.

        And get this: I read yesterday that people of higher status or position in life have higher serotonin levels. So maybe start in the neighborhood community action group, and work your way up until you are mayor of your town or governor of your state. Haha.

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          #19
          On Serotonin

          Exercise, chocolate and sex will help.

          LOL If only my body would crave these instead!!! :H
          "The person who says it cannot be done should not interrupt the person doing it"

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