Announcement

Collapse
No announcement yet.

Bac Naltrexone

Collapse
X
 
  • Filter
  • Time
  • Show
Clear All
new posts

    Bac Naltrexone

    Have we seen this?

    Abstract
    Recent surveys suggest that positive outcomes in the pharmacotherapy of alcoholism may be obtained through drug combinations. The present study evaluated the effect of the combination of the opioid receptor antagonist, naltrexone, with the GABAB receptor agonist, baclofen, on the acquisition of alcohol drinking behavior in Sardinian alcohol-preferring (sP) rats. Rats were treated with either saline, 0.5 mg/kg naltrexone, 1 mg/kg baclofen, or 0.5 mg/kg naltrexone plus 1 mg/kg baclofen once a day for 10 days. Alcohol was offered immediately after the first drug injection under the 2-bottle regimen. Alcohol intake in saline-treated rats rose to 5?6 g/kg/day within a few days, indicative of a rapid acquisition of alcohol drinking behavior. Neither naltrexone nor baclofen, when given alone, affected alcohol drinking behavior. In contrast, the drug combination resulted in a significant reduction in daily alcohol intake and retardation in the acquisition of alcohol drinking behavior. These results suggest that combination of naltrexone plus baclofen may result in a synergistic reduction in alcohol intake in sP rats. These results are discussed in terms of naltrexone and baclofen exerting a concomitant and reciprocally potentiating inhibitory action on alcohol-induced activation of mesolimbic dopamine transmission.
    Your time is limited, so don't waste it living someone else's life... And most important, have the courage to follow your heart and intuition. They somehow already know what you truly want to become. Everything else is secondary.

    Steve Jobs, Stanford Commencement Adress, 2005

    #2
    Bac Naltrexone

    shameless bump
    Your time is limited, so don't waste it living someone else's life... And most important, have the courage to follow your heart and intuition. They somehow already know what you truly want to become. Everything else is secondary.

    Steve Jobs, Stanford Commencement Adress, 2005

    Comment


      #3
      Bac Naltrexone

      Combination of Naltrexone and Baclofen for Alcohol Dependence:A Pilot Study. - Full Text View - ClinicalTrials.gov
      :nutso: I take pride in my humility :nutso:
      :what?:
      sigpic
      Graph of My Drinking From July '09 to January '10

      Consolidated Baclofen Information Thread




      Baclofen for Alcoholism and Other Addictions
      A Forum
      Trolls need not apply

      Comment

      Working...
      X