I just wanted to share my own experiences in case they may be of some use. I've tried a variety of medications over the years both to try and stop/cut down drinking and to treat other issues like anxiety, depression, and insomnia.
Unfortunately nothing seemed to be able to work for me while I was still drinking, which is why I detoxed over a week or so and then tried baclofen again. It has seemed a lot more effective in reducing cravings and also helping anxiety and depression now that I'm not drinking. When I used it while drinking it didn't help even in quite large doses (over 50 mg) and usually just combined with the alcohol to make me feel more out of it. I have used benzos too for quite a while but they didn't help anxiety or other issues while drinking, they merely helped to delay alcohol withdrawal symptoms in between binges. Campral was another med that had no benefits while drinking but did have benefits during a previous period of abstinence. Antidepressants have similarly failed when taken while drinking, or they've had unbearable side-effects. I am planning to try one of them again while sober if depression doesn't ease.
I tried naltrexone according to the Sinclair Method but didn't try it for the very long periods of time (eg. 6 months) that successful users have said is needed for it to work. I was using the much shorter time frames and graphs of extinction mentioned by Dr's Sinclair and Eskapa, and when I had no results at all after a couple of months I did not continue the naltrexone. For anyone reading this, yes I did take it 1 hour before drinking every time. It seemed to help somewhat during the first week, which others have called 'the honeymoon period', but after that I didn't notice benefits.
I would consider TSM again if all else failed to keep me sober, since at least this time I could hopefully start it at a much lower drinking level than when I was drinking 20+ standard drinks every night.
Regarding alcohol detox, I'm sure you know it must be done safely under a doctor's supervision or in a hospital/detox clinic, not cold turkey. I did mine as an outpatient under my doctor's supervision and it went well despite me drinking an average of 21 standard drinks (over 26 'units') every night for over a year.
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