How long does Naltrexone stays in your system?

[eight days a week]

How long does Naltrexone stays in your system?

GettingBetter;808092 wrote: A 50 mg naltrexone pill with a 4 hour half life will leave 0.78125 mg after 24 hours. If Dr Sinclair and/or Dr Eskapa say that the opiod-receptor blocking affects of 50 mg of Naltrexone last 24 hours I have no reason to disbelieve them. Mathematically that means the amount the body needs to be effective is less than 0.78125 mg. That's just how the maths works out. You can see that right?

I am not encouraging people to play with the dosage, I am merely trying to explain what a "half life" and the nature of exponential decay are.

Thanks, I understand both concepts. As far as I'm aware, Dr Eskapa and Dr Sinclair both think that 50mg Nal blocks 100% of the opioid receptors for up to 24 hours NOT 24 necessarily. Dr Eskapa has recommended a number of times that people who drink all day take a second tablet later on in the day to ensure 100% blockage. So, you calculating the half life and extrapolating the maths to say that you should still be covered at x% is a contradiction, because you are going against what Dr Eskapa himself says.

[GettingBetter]

How long does Naltrexone stays in your system?

eight days a week;808096 wrote: for up to 24 hours NOT 24 necessarily.

So, 23:59 rather than 24:00

The fact that the doctors say you should take another 50 mg pill if going over 24 hours suggests I'm in the right ballpark regarding the amount that needs to remain in your system to block the receptors (either that or the number is smaller).

I'm not going to repeat my explanation of the maths again. Hopefully other people will understand what I said.

[eight days a week]

How long does Naltrexone stays in your system?

GettingBetter;808103 wrote: So, 23:59 rather than 24:00

The fact that the doctors say you should take another 50 mg pill if going over 24 hours suggests I'm in the right ballpark regarding the amount that needs to remain in your system to block the receptors (either that or the number is smaller).

I'm not going to repeat my explanation of the maths again. Hopefully other people will understand what I said.

Your sarcasm isn't appreciated.

Dr Eskapa has said a number of times that if you're drinking 24/7 then you should take a second tablet later on in the day to ensure 100% coverage of your opioid receptors. NOT 23.59 hours later, but later on that very same day! Even 12 hours later, just to make sure!! That suggests you're completely in the wrong ballpark, and that comes from Drs Eskapa and, presumably, Sinclair.

Your maths skills, however logical, are irrelevant when we have it straight from the mouth of the guy who worked so closely on bringing Dr Sinclair's work into the consciousness of the Western world, and has years and years working directly with this method.

[GettingBetter]

How long does Naltrexone stays in your system?

I haven't got the book. You were the one who said "Dr Eskapa I believe says that 50mg should block up to 100% of the opioid receptors for up to 24 hours". If however they say 100% coverage ends after 12 hours then the amount is presumably around 6.25 mg. As I said before, I am trying to explain what a "half life" and exponential decay are.

[eight days a week]

How long does Naltrexone stays in your system?

GettingBetter;808118 wrote: I haven't got the book. If they say 100% coverage ends after 12 hours than the amount is 6.25 mg.
You should read the book and also read Dr Eskapa's messages about how 50mg may well not cover 100% of endorphin receptors for some people, particularly not over periods of more than twelve hours, before you start handing advice out on a message board about how long Nal works for.

OK this seems to be the third time you've edited your reply, and it's the last time I'll bother to check and to respond. Here is how your reply reads now:

GettingBetter;808118 wrote: I haven't got the book. You were the one who said "Dr Eskapa I believe says that 50mg should block up to 100% of the opioid receptors for up to 24 hours". If however they say 100% coverage ends after 12 hours then the amount is presumably around 6.25 mg. As I said before, I am trying to explain what a "half life" and exponential decay are.

The emphasis here is on 'should' 'up to' and 'up to', if I'm correct. They don't say 100% coverage ends after 12 hours, everybody is different. Everyone metabolizes meds differently, and everyone's physiology is different. Dr Eskapa has, though, recommended that 24/7 drinkers, or all day drinkers, should take an extra dose at around those times to make sure they are fully covered. So, the maths isn't quite as straightforward as you make out, which is why, in view of the original poster's question, I suggested that someone should email him to get a definitive answer.

[GettingBetter]

How long does Naltrexone stays in your system?

That's the last time I try to explain anything.

[MamaZum]

How long does Naltrexone stays in your system?

Hmm....interesting discussion.

[Lo0p]

How long does Naltrexone stays in your system?

Okay, this has gone on long enough. It's time for a lesson. :bat

[crown86]

How long does Naltrexone stays in your system?

Loop to the rescue with facts

If any non engineering mathmatical folks are reading this...simple before each major drinking session take the 50mg one hour before you drink to be safe...Sometime I would drink straight for 3 days...each day was generally broken up into 2 heavy drinking sessions because I would at some point pass out..I am sure most due...then come back/wake up and drink again...to be safe I took the pill each time. F-K the mathatics and half life...sorry to be crude but it is pretty simple IMO...Take the 50mg 1 hour before drinking...I read the book 5 times over from Dr. Eskapa...I am not engineer or matematician it was repeated over and over one hour prior to drinking.

[GettingBetter]

How long does Naltrexone stays in your system?

crown86;808261 wrote: Loop to the rescue with facts

If any non engineering mathmatical folks are reading this...simple before each major drinking session take the 50mg one hour before you drink to be safe...Sometime I would drink straight for 3 days...each day was generally broken up into 2 heavy drinking sessions because I would at some point pass out..I am sure most due...then come back/wake up and drink again...to be safe I took the pill each time. F-K the mathatics and half life...sorry to be crude but it is pretty simple IMO...Take the 50mg 1 hour before drinking...I read the book 5 times over from Dr. Eskapa...I am not engineer or matematician it was repeated over and over one hour prior to drinking.

Exactly. The number we were arguing about is completely irrelevant for our purposes. The experts say we should take 50 mg and in my experience it works for me (pre TSM I was a once a week heavy binger (~24 hour beer)).

I believe the fact that I'm posting this now at 07:00 on a Saturday morning and am relatively sober is testament to the Sinclair Method, and I've only been following it for one month.

[eight days a week]

How long does Naltrexone stays in your system?

Crown and GettingBetter, I am so glad you have had positive results with the way you have taken Nal, even though you're taking/have taken different approaches it seems.

Imho, and that of many others who have followed The Sinclair Method, this is not an irrelevant topic at all, it may become very important to anyone who follows TSM for some time. I thought I was just a week or two off declaring being totally 'cured' after around four months, but things soon took a backwards turn for me, drink-wise. Then of course there is the absolutely crucial issue of how long it stays in your body for medical reasons if you end up in ER.

Crown, in your case you were a 24/7 drinker, and took Nal twice a day, once before each big binge, to make sure you were definitely covered? Dr Eskapa has recommended a number of times that 24/7 drinkers do just that, to make certain.

And GettingBetter, you are (or were) a 24/7 drinker who has already seen good success after a month, just taking 50mg a day? That's tremendous, but again I believe it's Dr Eskapa's opinion that 24/7 drinkers should take extra just to be sure.

There are a number of enlightening topics on the subject over at the TSM forum, where Dr Eskapa has replied on the subject a few times. There are also threads where people have reported more success moving up to 100mg doses, and I know personally of at least one person who was recommended to try it by Dr Eskapa himself. Everyone's physiology and metabolism is different.

If anyone has any information that contradicts anything I've said in this thread (Lo0p you seemed ready to offer some input?), please do correct me, the last thing I want to do is mislead anyone. I'm just repeating what I believe I understand from a year following all the information I've read on the TSM forum for a year now, including a number of pieces of advice from Dr Eskapa, and having read the book.

Best wishes to all

[crown86]

How long does Naltrexone stays in your system?

eight days a week;810018 wrote: Crown and GettingBetter, I am so glad you have had positive results with the way you have taken Nal, even though you're taking/have taken different approaches it seems.

Imho, and that of many others who have followed The Sinclair Method, this is not an irrelevant topic at all, it may become very important to anyone who follows TSM for some time. I thought I was just a week or two off declaring being totally 'cured' after around four months, but things soon took a backwards turn for me, drink-wise. Then of course there is the absolutely crucial issue of how long it stays in your body for medical reasons if you end up in ER.

Crown, in your case you were a 24/7 drinker, and took Nal twice a day, once before each big binge, to make sure you were definitely covered? Dr Eskapa has recommended a number of times that 24/7 drinkers do just that, to make certain.

And GettingBetter, you are (or were) a 24/7 drinker who has already seen good success after a month, just taking 50mg a day? That's tremendous, but again I believe it's Dr Eskapa's opinion that 24/7 drinkers should take extra just to be sure.

There are a number of enlightening topics on the subject over at the TSM forum, where Dr Eskapa has replied on the subject a few times. There are also threads where people have reported more success moving up to 100mg doses, and I know personally of at least one person who was recommended to try it by Dr Eskapa himself. Everyone's physiology and metabolism is different.

If anyone has any information that contradicts anything I've said in this thread (Lo0p you seemed ready to offer some input?), please do correct me, the last thing I want to do is mislead anyone. I'm just repeating what I believe I understand from a year following all the information I've read on the TSM forum for a year now, including a number of pieces of advice from Dr Eskapa, and having read the book.

Best wishes to all

8

Yep I followed the book and everthing both doctors, Eskapa and Sinclair had to say aboout TSM. I figured they are the experts on TSM since one of them founded the method...why try to deviate. Also 8 totally agree with you on the how long it stays in your body in case of a medical emergency...I did what I beleive Plain Vanialla mentioned...put a card in my wallet that said I was taking naltrexone.

[Lo0p]

How long does Naltrexone stays in your system?

Okay, it took me a few days to get over being...angry (would be a nice word)... I'll just post some studies and some graphs I made in the past concerning the effective duration of action of naltrexone. I'll leave my commentary out of it...to be nice.

[Lo0p]

How long does Naltrexone stays in your system?

This is a graph I made illustrating the plasma half life of naltrexone. Upon first pass metabolism, most of the naltrexone dose is converted by the liver into one many metabolites. The most important of which is 6-beta-naltrexol, which has a half-life of 13 hours. It alone is responsible for most of the effects of a naltrexone pill, not naltrexone itself. Ignore the commentary about 'blockade failure'. This was just a guess i made, ignore it completely.

[Lo0p]

How long does Naltrexone stays in your system?

But plasma concentration isn't nearly the whole story:



So nal and 6-b-nal seem to hang on to the receptors much longer than their plasma clearance times would suggest