Bac at 300mg +

[tiptronic_ct]

Hello, All

I've been in email contact with a MWO "lurker" who is now on 290mg a day. He is experiencing diminishing cravings, but he's not there yet.

He's concerned about going over 300. He weighs about 70kg and is currently taking his bac in three roughly equal doses, with a smaller dose in the mornings, the biggest one in the afternoon and a final one in the evening. Cravings set in at around 7.00 p.m.

My "gut" tells me he should be taking his last dose earlier in the day, or increase the afternoon dose further.

My approach to baclofen wasn't very "scientific" so I'm hoping people like Lo0p, Bernard, Beatle etc will weigh in with advice. In my opinion, bac is safe, and I have a figure of 5mg per kg somewhere in the recesses of my brain - which means he can easily go up to 350mg. For the life of me, I can't remember where I read that...

Advice, guidance & pointers to relevant info appreciated! Particularly around dosing schedule & safety of 300mg + of bac.

:thanks:

[tiptronic_ct]

Bac at 300mg +

OK, correction: he's just told me that I listed the incorrect dosage schedule.

He is taking: 80 at 10 am, 100 at 4:30 pm ,100 at 11 pm

I can already see a problem with that: if cravings set in at around 7.00 p.m., he should be taking the majority of his bac well before then.

I'm thinking out loud that an alternative might be: 80 @ 10.00, 100 @ 14h00, 100 & 17/18h00, and titrate up by adding more bac to the the last two doses.

[NC]

Bac at 300mg +

I am at 280 mg a day, in four equal doses of 70 mg at 8:30 AM, 12:30 PM, 4:30 PM, and
8:30 PM. I have diminished cravings but am not indifferent. I went up to 290 mg by taking 80 mg for my last dose and had terrible somnolence the next day, so back down to 280 for a couple of days without somnolence. I am going up to 285 tonight by adding 5 mg to my last dose and see how I do tomorrow.

I am also taking nal each day at 4:30 and then have 2 or 3 glasses of wine with dinner.

I am 84 kilos.

I plan to continue up gradually. I don't really have an upper limit determined at this point.
But I feel pretty comfortable going over 300.

NC

[santybury]

Bac at 300mg +

tiptronic_ct;835031 wrote: OK, correction: he's just told me that I listed the incorrect dosage schedule.

He is taking: 80 at 10 am, 100 at 4:30 pm ,100 at 11 pm

I can already see a problem with that: if cravings set in at around 7.00 p.m., he should be taking the majority of his bac well before then.

I'm thinking out loud that an alternative might be: 80 @ 10.00, 100 @ 14h00, 100 & 17/18h00, and titrate up by adding more bac to the the last two doses.

Hi Tiptronic!!
I came here after you bcalled me a "Bac head!", lol! Sent you a reply on my last thread that you replied too! Anyway, maybe I can help here, (with my extensive knowledge of Bac! ...Not!) I went on one of the posts on here and some one had put a link to the most amazing baclofen website. The guy doing it is called Dr Phill, (Not the Oprah guy) He is soo helpful and wants to hear from and help anyone struggling with alcohol probs and especially those fighting it with baclofen. He took the time to send me 2 really great personel emails and is writing a book about our trials and tribulations. I know its on this discussion board, (its a thread wich lists loads of baclofen websites if that helps) I daresay if you type in Baclofen and Dr Phill, it will come up. I will post it on this thread when I find it later. Hope this may be of some help!
Thanks x

[wort]

Bac at 300mg +

tip,

I am early in my baclofen regimen, but this is what I think. I sleep well with baclofen, so I would definiitely take a larger dose before bed. I drink in the evening, so I would take a larger dose at 6:00. Perhaps next: 60@8:00a, 80@12:00p, 80@6:00p, 80@10:00p.

I definitely see an advantage in dosing four times per day. Sometimes I take an extra dose if I wake up (as I often do) at 3:00a.

Please send your friend my best regards.
-wort

[bernard]

Bac at 300mg +

From all that I've read in the literature, whether in humans or animal "models," there is no identified bad effect of very high doses -- other than just the side effects themselves. And there is no objective reason for the 300 limit, other than that's as high as most patients can tolerate before switching to intrathecal.

In other words, if it feels OK, it is OK. So titrate at a moderate rate, don't drive, have a person on watch who knows what you're doing, and report back to us. Alcoholics (of the bac-responsive type) probably tolerate higher doses than most of the population for the same reason that they are drawn to alcohol--they need the dampening effect of GABA.

[manlooking4nothing]

Bac at 300mg +

Hello

hello every one .

Thanks :thanks: for tiptronic_ct to start this thread on behalf of me .iam lurker and this is my new ID .

Iam on 300 mg per day ,i still have craving and terribly sleepy ,iam not working right now so looks like i want to go more and more until i get the switch.

.looks like id ont have any other side effects .i have solved my sleep disorder recently and Iam happy about it .

let me know if anyone going past 300 MG

[tiptronic_ct]

Bac at 300mg +

Hello, M4N!

I'm glad you've posted!

Why not use this thread to keep us posted on your progress? Especially if you start changing the times of day that you take your bac - I really feel you have room to get better results that way.

[craving]

Bac at 300mg +

Baclofen is studied and considered safe up to 290/300mg a day.
But I have seen Ameisen trying to get a patent for Baclofen use up to 500mg.

I heard that Baclofen can cause around 500mg some nasty effects.

I would consider it up till 400mg OK ... although I am not a doctor ....

[tryagain]

Bac at 300mg +

Hello manlooking4nothing

Just wanted to say Hi, I lurked here too without posting for some time.

I think your journey will be very intertesing and useful for others to come who will be in the same situation as you, we are a pioneer group of drinkers I guess, I do hope you continue posting your progress.

I wonder if you might want to contact the English speaking member of the french forum that Dr. Ameisen mentions in his post as they have many members there and probably have had others that have had to go higher than 300mgs and may be able to give you advice.

:welcome:

[manlooking4nothing]

Bac at 300mg +

iam doing 300 mg since 3 days .
I feel sleepy in the day,since iam not working anywhere i just go to sleep and sleep for an Hour or so .
otherwise Iam just cool and continue my daily routine as usual .

My hardcore craving have lessened but i cant say i have the switch ,still waiting for it .
thanks for:thanks: "tryagain" suggesting the French english speaking group.......ill try that too.

[beatle]

Bac at 300mg +

I think going so high would depend on your height/weight. A daily dose of over 300mg for a 190cm/100kg man, for example, would be very different than it would be for a 165cm/48kg woman, for instance.

[Virgil]

Bac at 300mg +

Post deleted.

[beatle]

Bac at 300mg +

Virgil;837686 wrote: beatle,

According to the https://www.mywayout.org/community/f2...oll-39548.html, there is little correlation between body weight and the baclofen dosage required to experience the 'switch'. For example, two males each weighing 75 kg hit the 'switch' at:

Male 1: 120 - 140 mg per day and
Male 2: 300 mg per day

Similarly, two females each weighing 55 kg hit the 'switch' at:

Female 1: 90 - 110 mg per day and
Female 2: 150 - 170 mg per day

I can't comment about height as the Baclofen Dosage 'Poll' did not gather that data.

Interesting, isn't it?

V.

Yes, very interesting, but I wouldn't agree to saying there is little correlation. Yes, there is great variation, but if you look at most of the switches, I think you will find that there is indeed a correlation. And in fact, your examples evidence this -- those who weighed less hit the switch at less. I doubt a 55kg woman would need to, or more importantly, could have gone up to 300mg/day.

I'm no scentist (that's for certain), but my theory on this is that brains that are more depleted (I almost wrote 'deleted':H), for whatever reason, need more bac before they hit the switch than those brains that are, for whatever reason, less in need.

Still, the weight correlation would apply to some extent (although with individual variation, in some cases great variation) simply because the brain would get more at a time with a higher dose in a smaller body, and side-effects would be intensified with much higher levels of concentration of bac in the blood. Just my little theory.

Unfortunately, but not surprisingly, I'm afraid I am one of those with the neediest brains and the smallest bodies. :upset:

[Virgil]

Bac at 300mg +

beatle;837703 wrote: Yes, very interesting, but I wouldn't agree to saying there is little correlation. Yes, there is great variation, but if you look at most of the switches, I think you will find that there is indeed a correlation. And in fact, your examples evidence this -- those who weighed less hit the switch at less. I doubt a 55kg woman would need to, or more importantly, could have gone up to 300mg/day.

I'm no scentist (that's for certain), but my theory on this is that brains that are more depleted (I almost wrote 'deleted':H), for whatever reason, need more bac before they hit the switch than those brains that are, for whatever reason, less in need.

Still, the weight correlation would apply to some extent (although with individual variation, in some cases great variation) simply because the brain would get more at a time with a higher dose in a smaller body, and side-effects would be intensified with much higher levels of concentration of bac in the blood. Just my little theory.

Unfortunately, but not surprisingly, I'm afraid I am one of those with the neediest brains and the smallest bodies. :upset:

beatle,

Thanks for correcting me. That's why I have chosen to delete my original post.

V.