Bac at 300mg +

[manlooking4nothing]

Bac at 300mg +

thanks virgil and beatle .

brain depletion ! thats good logic .

i weigh 70 kg and my height is 5 feet 9 inches .I have a history of binge drinking almost any part of the day........ not just evenings like others .

my history if baclofen intake is also different from others ,this is the 3rd brand that iam trying.

The 1st brand i had up to 200 mg then i had to switch to another brand so i had to titriate down to 100 ,and the second brand i had up to 280 and i had to titriate down again to 200 and start the 3rd brand .

There are also other 2 factors.

1 .Drug tolerance : Some people always need more MG of drugs than others
simply because they are tolerant to prescription drugs.it could be any drug.

2. iimmunization :a phenomena commonly found in pest's ,similar mode of
pest control over the years /season make the pest immune to that
particular pesticide.

all these factors plus my binge drinking history collectively brought me up to 300 +

This is just my assumption based on possibilities what you think so ?

[houtx]

Bac at 300mg +

I am only coherent in the metric system. I weigh 135 - 140 lbs. From what I understand my switch might happen about 120 mgs?? I'm so far early in my 2nd week and decided to only up my dose to 20 mgs/day instead of 30mgs/day as recommended. So I took 10 mgs earlier and 10 mgs later. So far so good. Will continue on with this for the next 4 days.

Then do 30 mgs - 10 mgs/3x day for a week. See how that goes. So far so good!

[houtx]

Bac at 300mg +

I am only coherent in the metric system. I weigh 135 - 140 lbs. From what I understand my switch might happen about 120 mgs?? I'm so far early in my 2nd week and decided to only up my dose to 20 mgs/day instead of 30mgs/day as recommended. So I took 10 mgs earlier and 10 mgs later. So far so good. Will continue on with this for the next 4 days.

Then do 30 mgs - 10 mgs/3x day for a week. See how that goes. So far so good!

[hopefulspirit]

Bac at 300mg +

Oh, I have serious brain depletion... Is that a permanent condition?

[beatle]

Bac at 300mg +

manlooking, I tried to respond to your PM, but it was rejected. Another member also tried, with the same result.

[wort]

Bac at 300mg +

All,

I am currently at 275mg/day. I weigh 185lb. To convert to kg, multiply by 0.454: 185*0.454 = 84kg. Thus, my current dosage is 275mg/84kg = 3.3mg/kg. Ameisen hit is switch at 3.8mg/kg, which for me would be (3.8mg/kg)*84kg = 320mg/day. I should be there in about two weeks.

It would be very interesting to get an update from some of you who were at high dosages when this thread started.

I struggle daily with SE's. Most recently, asthsma. I am certain that it is from baclofen. My outbreaks correlate closely with taking it, and it is much worse when increasing my dosage. My GP prescribed several medications, and so I forge ahead. I of course have all the other SE's, including somnolence during the day, insomnia at night, etc.

Best,
-wort

[rudolf]

Bac at 300mg +

hey tip
i was on 350 /day and far off the switch until i found out that the AD i took has neutrallized the bac...i could have taken 1kg and wouldnt have gotten there......if your friend is taking an AD he might have the same problem, mine was cymbalta, i dumped it a week ago, am on 200 now and have the feeling i dont even need that....no craving, NOTHING, 10000% indifference...

[azuldog]

Bac at 300mg +

bernard respect

bernard;835214 wrote: From all that I've read in the literature, whether in humans or animal "models," there is no identified bad effect of very high doses -- other than just the side effects themselves. And there is no objective reason for the 300 limit, other than that's as high as most patients can tolerate before switching to intrathecal.

In other words, if it feels OK, it is OK. So titrate at a moderate rate, don't drive, have a person on watch who knows what you're doing, and report back to us. Alcoholics (of the bac-responsive type) probably tolerate higher doses than most of the population for the same reason that they are drawn to alcohol--they need the dampening effect of GABA.

Bernard I have read your responses for several weeks and respect your disrespect of the establishment. I believe you are mentoring someone else but I could be wrong, and havent taken Bac you self. I can tell you that it is not innocous (sp?) I had great hopes from reading Dr. A's book. However, I experienced stronger SE's than any drugs I took back in the 60's. No disrespect for your mind here, please. I really wanted it to work per A's book but I experienced 95% of the sympthoms of withdrawal per quoted in Wikipedia....and this was on the the way UP. One the way UP. I tolerated it until I became impotent and crazy.

I know rate of titration is important and it works for some people. I followed directions and I got very fuked. I write this only because I respect your mind. Would you mind responding or PMing me. azulddog

[bernard]

Bac at 300mg +

azuldog,
I'm honored by your attention. Alcohol and alcoholism are multifaceted; people get hooked because of more than one mechanism; i.e. it's different for different people. Ameisen's brand of anxiety-driven drinking is probably the largest category. If there are people here for whom bac was your silver bullet and did NOT have anxiety, please tell us. Yes I am a patient advocate for a friend who gave bac a good try. Not only did it not work, but it brought on depression which has abated now that she takes it only at bedtime and at modest doses. I'm still a strong proponent of bac because it is the first big success, and I think it is the bellwether of a sea change in therapy, and eventually, in society's attitudes (but that will take 3 generations). I read about your troubles, and have no disagreement with your decision to discontinue bac. You are certainly is good company with those--thankfully the minority--who can't take the side effects (and for whom bac many not do its trick anyway). I've nibbled a few bacs here and there; not enough to feel anything; just a curiosity. This disease is usually tangled up with dual-psychiatric and psychosocial maladies which makes it the life-and-death battle that it is for so many. I hope you keep us posted on your journey.
Bernard

[PhoenixRising]

Bac at 300mg +

What is the range that Dr. A said most people hit the switch (kg/mg) ?

[wort]

Bac at 300mg +

Hi PR,

Ameisen's switch was at 3.6 mg/kg - I just looked it up. I recently hit the switch, but had to go quite a bit higher - 4.6mg/kg; for my weight, that was 380mg/d. I have been AF since 7/15.

-wort

[PhoenixRising]

Bac at 300mg +

wort;928237 wrote: Hi PR,

Ameisen's switch was at 3.6 mg/kg - I just looked it up. I recently hit the switch, but had to go quite a bit higher - 4.6mg/kg; for my weight, that was 380mg/d. I have been AF since 7/15.

-wort

Interesting. That's *exactly* where I mine as well (3.6)

[tiptronic_ct]

Bac at 300mg +

Woohoo!!!!!!!

I had an email from manlooking4nothing the day before yesterday.

He finally hit the switch - at 400mg. He has since slowly titrated down to his current maintenance dose of 280.

I am also very happy to report that he has since been able to resume his career and sounds much perkier than the fairly depressed man we saw posting a few months ago.

It is incredible that we're starting to see more success stories coming through. And that people are courageous enough to "stick with the program".

[manlooking4nothing]

Bac at 300mg +

Hello Everyone & thanks tiptronic_ct for the post

I just hit the switch on Aug 21 or 22 of 2010 or so !

AF since then ,My baclofen journey was real jerky ,had to switch many brands. since Iam from India there were many baclofen choices . Finally I got my switch with a brand called “BACLODOL “as I had problems with local shipment with BacMax and other brands.

I extend my sincere gratitude to “tiptronic_ct” & “corkit “ who personally helped and guided me through various phases of my jerky baclofen journey .Also thanking all members of this blog especially the “consolidated baclofen success thread “ members and moderator/creator.

While I was on 280 mg of baclofen (BacMax) I start to have trouble with the shipment as the agent refused to deliver the package due to some legal issues ,so I had to switch to “baclodol” rather less spoken or unknown brand of baclofen , I was a bit skeptical about this brand at 1st . I was drinking too.

I donno what happened to me one day ,I happened to jump off from the 1st floor of my building and injured myself ,got bed ridden for 2 months (very lucky that I had no fracture anywhere in my body,my doc looked at the x ray ,smiled and told that its aint yet time for you to die).so I suggest other lurkers not to switch brands of baclofen at very high doses if you are still drinking ,my experience says that its very dangerous.(switching certain brands can bring withdrawal , and if you are still drinking things are lethal )

So since I got bedridden I had to stop drinking and also my family confined me strictly at home , I continued my baclofen journey slowly up to 300 mg and then 400 mg all these because I was skeptical about the brand and I wasn’t drinking and I donno if I had switched or not .I was on 400 mg for a week and then titrated down slowly ,meanwhile I had to be in Bombay for a new job and I started to drink again but this time only 3 beer’s a day and that only in the nights (in India some beer have nearly 40% alcohol v/v ) , now I started to get confident so I titrated up to 280 within 3 days and see …………I just got switched ! I never drank since 22 aug 2010 .

Its rainy in Bombay so each time I come to my hotel after work my taxi halts in front of a bar(next to my hotel),so I have to go into the bar until the rain subsides .I couldn’t believe what was happening ……..i was the only guy in the bar eating food without ordering a single drink.

Thoughts to the Lurkers:

So my sincere advise for Lurkers is that try to avoid alcohol while you are in high doses of baclofen if you can’t at least reduce the units . don’t wait for the switch to happen if you are drinking ,just induce baclofen blindly to the maximum dose as possible (for me I just blindly went up to 400mg).baclofen works well when you don’t drink or drink less units(maintain a drinking unit diary).

Please notice that I never got switched at 280 while I was titrating UP but other way around !

Baclofen is absolutely safe if your work don’t involves driving or any other dangerous activities like working in a complex and dangerous factory environment etc. Otherwise its pretty cool. please don’t mind other problems like lack of sexual appetite, sleep disorder, scary dreams, tingling, limb numbness, enlarged puples, Disorientation ,Mood disorders, acute sleepiness, hair graying, loss of hair and things like that ……..all these side effects are just temporary and things will be normal eventually when you titrate down .

Whatsoever baclofen are not candies but proper pharmaceutical drugs which have to be treated that way. and getting to a switch is not just a walk in the park.

so I suggest other lurkers not to switch brands of baclofen at very high doses if you are still drinking ,my experience says that its very dangerous.(switching certain brands could bring withdrawal , and if you are still drinking things are lethal )

Please keep a check on mood disorder issues ,understand that it’s because of baclofen and its only temporary ,let someone dear and near know what you are doing and keep close contact to MWO forum members ,all of them are helpful and all the threads are useful .

I extend all possible help to lurkers, you can also mail on my personal ID (apparentajiesh@rediffmail.com)

Best & Good luck

manlooking4nothing

[Seethepony]

Bac at 300mg +

Congratulations Manlooking4nothing,

I had to laugh at "please don’t mind other problems like lack of sexual appetite, sleep disorder, scary dreams, tingling, limb numbness, enlarged puples, Disorientation ,Mood disorders, acute sleepiness, hair graying, loss of hair and things like that"...

So far my only side effects (on a timid 75mg/day) have been dreadful hangovers which (of course) abated once I avoided alcohol for a few days -- and a not unpleasant sleepiness, especially at night. Strangely, I think I might be at or near the switch as I have visitors at the moment drinking wine and beer every evening and I don't feel at all inclined to join them in their boozing. So, so far, I have had a couple of terrible days where I wondered whether to continue (when I went from 10 ->20 mg 3 times a day, maybe too much of a jump) but mostly I have been pleasantly surprised by the lack of horrible side effects.

Waking up with no hangover is the best side effect of all...