Baclofen is an agonist -- which means (from my limited research and understanding) that it mimics the action of a naturally occurring substance in the human body. It seems to me that baclofen for alcoholics is like insulin for diabetics. There is something missing in an alcoholic's physiology, and baclofen provides that natural element, albeit in a chemically devised form.
I have hypothyroidism. My body needs thyroxine to make up for my thyroid's inability to produce this vital natural substance itself. I will take it every day of my life, because I have to, and it is taking the place of what my body naturally would be doing if I were not plagued by this disease.
It so happens that you can get the thyroxine completely naturally (from pigs' thyroids). Many people prefer this option, because they perceive it as more "natural" and believe it is more effective.
I imagine (although I don't know) that it would be possible to extract baclofen from cows or pigs or horses. I don't know if it is possible or if it is being done. Either way, I prefer the artificial version for ethical reasons.
I believe most vitamins used these days are similar, in that they are not "natural", but "chemical" -- made in a laboratory to mimic the real thing and make up for (supplement) missing elemnts in one's diet and lifestyle.
Please disagree with me and show me where I have take a wrong turn. Sometimes I need to be put in my place ;-)
You are right. Baclofen mimics endogenous GHB. Alcoholism is described by Ameisen as being a functional or quantitative shortage of GHB which is the chemical which allows us to de-stress. Alcoholism is a Gaba-b mediated dysphoria. Alcohol mimics GHB and Baclofen is synthetic GHB so they all do the same thing to our Gaba-b receptor, except alcohol does a lot more. I don't think you can get Baclofen from other animals; I don't know how it is produced. It has been around since the 1920's as a treatment for epilepsy. GHB is used in Italy as a treatment for alcohol withdrawal under the name Alcover.
Otter
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