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    #76
    Baclofen Efficacy Reversal

    Thanks for sharing your personal correspondence, John. I really appreciate it.

    I understand your reluctance to go down. I was way too eager, and am very grateful that I went back up relatively quickly. After I went down I drank a beer or two a couple of times a week, socially, with my husband who was still drinking alcoholically at the time. It didn't instigate craving but it was the booze was still there... I kept wondering if/when the beast/craving/disease was going to kick in full force and return me to drinking against my will. It was a couple of months later that I decided to completely abstain for 30 days, which of course was effortless. I still drink very occasionally. A glass of wine with dinner, perhaps. Frankly, this was an immature response to the status quo that says we can never be well--that alcohol and alcoholism will always be a part of our lives. I still revel a bit in the fact that I do not count days, do not see alcohol as a threat, do not have to think about it at all. (What can I say? I'm human. It feels good to thumb my nose a bit. I'll grow out of it, I suppose! ) I do not suggest, recommend or advise this course of thought or action! :H

    Ironically, I was one of the ones that swore I would never drink again once I was freed from the burden. I think for me, and for many others, it simply takes time. Indifference comes and there is still the habit, of course. But there is also a childish glee in consuming something that used to be so consuming. Silly, as I said. And quite possibly dangerous. Now I am more likely to see booze as simply a bad choice for my health. I'm lethargic and out of sorts after only a drink. I'm too busy for that nonsense!

    As to OA and the titration: He started bac in 2002, got up to 180mg but was still bingeing despite the cessation of anxiety and lowered craving. In 2004 he went down to 30mg to begin his titration up to 270mg where he found that he was indifferent while sitting in a bar in a ski lodge in Megeve. Would that my own realization was that glamorous. (It is to this American anyway!) (p. 147-168 in The End of My Addiction)

    When rereading the passages last night I was struck by this sentence: "There were no interfering 'parasite' thoughts, which usually invade and preoccupy the mind almost constantly in addiction." (167)
    That is SO true for me. It's been so long since I've picked up the book I had forgotten how succinctly he sums up the experience of being indifferent. Those consuming, persuasive, overwhelmingly negative parasitic thoughts are gone. Is that true for you, too?

    Power on, John! Very glad you're here!

    Comment


      #77
      Baclofen Efficacy Reversal

      John, try this link for the article:

      "Science" Article Olivier Ameisen emailed me : Scientific articles
      Good judgment comes from experience; experience comes from bad judgment.

      Comment


        #78
        Baclofen Efficacy Reversal

        Hi John, I am so glad you are feeling wonderful!! I can't keep track of all the comments and answers here it gets overwhelming for me. it does seem that going by weight is not the way to go and that we all have to go by how we feel. last night I took only 10mg but 3 hours later i felt CALM! and almost giggly. I have taken up to 50 mg of bac but this time i am getting the liquid version from Virtuous labs so who knows maybe there is a difference. My main goal is to eliminate life destroying anxiety. I guess i will wait and see what happens down the road once I reach my switch. Honestly if I feel good i don't see a reason to titrate down. In Amiesen's book he titrates down because he wasn't able to stay awake! I need to commit some time to reading that part of his book again. You mentioned formerly being disabled and isolated and that is exactly what my life is like right now. This is why it is so paramount to get rid of this anxiety and stop using alcohol to self medicate so I can back to living life. That is my goal and that is why I am here. Thanks for sharing your journey. I posted my own thread today as I begin this healing adventure too. Andrea

        Comment


          #79
          Baclofen Efficacy Reversal

          Grommet;1230322 wrote: John, try this link for the article:

          "Science" Article Olivier Ameisen emailed me : Scientific articles
          Thanks Grommet. This is the exact article that Dr. A attached to his e-mail reply above and forwarded to Dr. L as well. But though I was grateful for his thoughtful message, this was not the article I was referring to. Dr. L explained that it was recently discovered how addiction forms (through a "binding" of the protein BDNF and neurotransmitter GABA), and how Baclofen works in restoring balance in neurotransmission (by "unbinding" them). He said there was an article about it in the journal Science, and that it was back in June 2009. But he then later added: "up to this last summer".

          I did extensive research first in the annals of Science, then through Google searches using varying search queries. I found several articles that appear to be what I was looking for, many of which are posted here somewhere in another topic (as they also came up in my searches eventually), as well a few other gems which are not included here (which I intend to post when I have all my i's dotted and t's crossed).

          Problem was, none of the scientific articles definitively spelled it out in layman's terms for the average reader to comprehend... mostly a lot of scientific jargon. But a couple of others (which I'll add to the thread wherein the other research articles have been shared sometime soon), were compressed and simplified for better clarity.

          This is the article I believe Dr. L was referring to:

          Ventral Tegmental Area BDNF Induces an Opiate-Dependent–Like Reward State in Na?ve Rats

          And this one was referenced just below it:

          BDNF and Drug Dependence

          Through researching the myriad of articles I found, I do believe I fully understand now how addiction forms biologically, as well as how Baclofen works to correct it. But it wasn't spelled out all in one article... bits from this one and pieces from that one. Once I have all my ducks in a row (after perhaps after even consulting with F and/or O), I intend to post my hypothesis along with links to all the articles by which I formed the overall conclusion. Then I intend to share this info with all the ignorant doctors I've seen here in Omaha over the last three years. They're all clueless!

          I want to get the word out in hopes of helping others on a local level. Needless suffering is just that... needless. Simple ignorance on the part of the medical field is mostly to blame for this. And from all I've gone through on this journey, I hope to change that.

          ~John

          Comment


            #80
            Baclofen Efficacy Reversal

            Ne/Neva Eva;1230299 wrote: As to OA and the titration: He started bac in 2002, got up to 180mg but was still bingeing despite the cessation of anxiety and lowered craving. In 2004 he went down to 30mg to begin his titration up to 270mg where he found that he was indifferent while sitting in a bar in a ski lodge in Megeve. Would that my own realization was that glamorous. (It is to this American anyway!) (p. 147-168 in The End of My Addiction)

            When rereading the passages last night I was struck by this sentence: "There were no interfering 'parasite' thoughts, which usually invade and preoccupy the mind almost constantly in addiction." (167)
            That is SO true for me. It's been so long since I've picked up the book I had forgotten how succinctly he sums up the experience of being indifferent. Those consuming, persuasive, overwhelmingly negative parasitic thoughts are gone. Is that true for you, too?

            Power on, John! Very glad you're here!
            Aha, I sit corrected. It's been a while since I've wiped the dust off of my copy as well!

            Comment


              #81
              Baclofen Efficacy Reversal

              penelope67;1230417 wrote: Hi John, I am so glad you are feeling wonderful!! I can't keep track of all the comments and answers here it gets overwhelming for me. it does seem that going by weight is not the way to go and that we all have to go by how we feel. last night I took only 10mg but 3 hours later i felt CALM! and almost giggly. I have taken up to 50 mg of bac but this time i am getting the liquid version from Virtuous labs so who knows maybe there is a difference. My main goal is to eliminate life destroying anxiety. I guess i will wait and see what happens down the road once I reach my switch. Honestly if I feel good i don't see a reason to titrate down. In Amiesen's book he titrates down because he wasn't able to stay awake! I need to commit some time to reading that part of his book again. You mentioned formerly being disabled and isolated and that is exactly what my life is like right now. This is why it is so paramount to get rid of this anxiety and stop using alcohol to self medicate so I can back to living life. That is my goal and that is why I am here. Thanks for sharing your journey. I posted my own thread today as I begin this healing adventure too. Andrea
              Sounds like we have something in common. Crippling anxiety, particularly in social situations was one of the main reasons why I drank. But then of course, my anxiety was all the worse the next day... vicious cycle! You're going to love how Baclofen not only removes craving and will make you indifferent to alcohol, but also how it will all but remove your debilitating anxiety. It "kills two birds with one stone". I'm excited for you! I'll look for your topic and will post my personal trial log very soon... maybe tonight after work. Take care.

              ~John

              Comment


                #82
                Baclofen Efficacy Reversal

                crippling anxiety is about right. I have gotten so used to it it almost feels normal and i think that's why the steroids the doc gave me for my asthma pushed me right over the edge that i did not know I was standing on. I wasn't capable of taking on even a drop more of anxiety. My friends don't understand me bkz mainly they see me out at the bar when i am drunk and i don't have anxiety then. They don't know who i am the next day or the days that follow. And yes, absolutely, the day after drinking my anxiety levels skyrocket. What a horrendous way to live. After the ER incident I realized how alone i am and that i barely have any close people. My drinking friends were clueless and useless in a crisis. it was a rude awakening for sure. it's nice to know someone understands and yet i wouldn't wish any of this on my worst enemy. Already at 30 mg of bac i feel a certain joy, but I still very much do not want to leave my apartment. I have to go out today so i will see how I feel... Thanks for responding to my posts. I look forward to reading your log. Andrea

                Comment


                  #83
                  Baclofen Efficacy Reversal

                  No more Celexa for me

                  I was on Celexa about 8 months ago and my cravings for both alcohol and sugar went through the roof. I gave into the sugar craving mostly. One night I eat a whole gallon of ice cream on the Celexa. I got off the Celexa and instead got put on Busporne and that cleared up both my anxiety and my sugar/alcohol cravings.

                  Another better option for depression I think is 5HTP. I take that once in a while and it kills sugar cravings and is a great mood booster/sleep aid.

                  -John
                  **************
                  Baclofen Benefits: https://www.mywayout.org/community/f20/baclofen-benefits-45389.html

                  :bagdude: "It is our attitude at the beginning of a difficult undertaking which more than anything else, will determine its successful outcome."-Williams James

                  Comment


                    #84
                    Baclofen Efficacy Reversal

                    yup SSRI's are famous for causing sugar cravings. I think it's bkz they block the brain's "uptake" of serotonin, so the brain desperate to make more serotonin needs more sugar to carry Tryptophan over the blood brain barrier. I got this little tidbit from the book "Potatoes Not Prozac"

                    Comment


                      #85
                      Baclofen Efficacy Reversal

                      5HTP

                      Have you ever tried 5HTP? It actually raises your seretonin levels in your brain. I notice the effects within an hour of better mood and zero sugar cravings.
                      **************
                      Baclofen Benefits: https://www.mywayout.org/community/f20/baclofen-benefits-45389.html

                      :bagdude: "It is our attitude at the beginning of a difficult undertaking which more than anything else, will determine its successful outcome."-Williams James

                      Comment


                        #86
                        Baclofen Efficacy Reversal

                        yes I have but not steadily. Like most things it helps me one day but not the next. maybe I will try it again today to see what happens.

                        Comment


                          #87
                          Baclofen Efficacy Reversal

                          Mirawizad;1239972 wrote: Have you ever tried 5HTP? It actually raises your seretonin levels in your brain. I notice the effects within an hour of better mood and zero sugar cravings.
                          penelope67;1239979 wrote: yes I have but not steadily. Like most things it helps me one day but not the next. maybe I will try it again today to see what happens.
                          There has been a bunch of discussion previously about 5HTP. It is contraindicated with both ADs, and other serotonin enhancers, and vitamins B. It seems like we need vitamins B, as they are depleted and not readily available for those of us who drink too much. And there isn't much I've found about baclofen and serotonin, meaning that it might increase serotonin, too. (I'm not sure, maybe someone else can clarify?)
                          L-tryptophan doesn't seem to have these contraindications. And it should be taken with vitamins B, I think.
                          I'm far from a supplement expert, though. You can find a bunch of info about this stuff from Bruunhilde, Beatle, and some others around here!

                          JWHIII;1230471 wrote:
                          Sounds like we have something in common. Crippling anxiety, particularly in social situations was one of the main reasons why I drank. But then of course, my anxiety was all the worse the next day... vicious cycle! You're going to love how Baclofen not only removes craving and will make you indifferent to alcohol, but also how it will all but remove your debilitating anxiety. It "kills two birds with one stone". I'm excited for you! I'll look for your topic and will post my personal trial log very soon... maybe tonight after work. Take care.

                          ~John
                          Hiya, John. It's been forever! Where are you???

                          I didn't even know it was anxiety I was after, social or otherwise, until it was gone! It was an amazing revelation for me. And I think I only noticed it because it would creep back in from time to time. It was definitely an "Aha!", full circle moment for me. (Thanks, Oprah, for the catchphrase. )

                          Hope you're well!

                          Comment


                            #88
                            Baclofen Efficacy Reversal

                            I was gone using my lower dose of Baclofen and drinking about once or twice a week and binge drinking at my brothers once every few weeks. Better than how I used to drink daily for the most part for 10 years. Until over Christmas holiday and lots of vacation from work I decided I could drink for five days straight. Very wrong idea!!! It took me upping my dose of Baclofen and just yesteday I am back to feeling normal again after a week and a half - meaning my anxiety is gone. Such a nice feeling again (finally), but it took a while to get back this time, not just one day. Moral of the story: Drinking is so not worth it to me. And come to think of it baclofen kills around 60% of any positive effects of drinking anyway so what's the point?

                            -John
                            **************
                            Baclofen Benefits: https://www.mywayout.org/community/f20/baclofen-benefits-45389.html

                            :bagdude: "It is our attitude at the beginning of a difficult undertaking which more than anything else, will determine its successful outcome."-Williams James

                            Comment


                              #89
                              Baclofen Efficacy Reversal

                              Ok, so I'm currently on 20mg of Citalopram (Celexa) and just ordered by Bac. I'm getting concerned now because w/out my Citalopram I'm a royal bitch! Big time mood swings. Should I try to go down to 10mg before starting Bac? (which I've tried and not produced good results) I have not told my primary physician any of my drinking "issues" and would prefer to not tell him. He's the one who prescribes the Celexa. What do I do???

                              Em

                              Comment


                                #90
                                Baclofen Efficacy Reversal

                                Em,
                                Hey! Listen, there's a lot to think about here. A lot of things to know and understand. Reasons to be cautious.
                                But here's the thing, for every horror story you find, there are several more where people were just fine.
                                Some people mix the two, antidepressants and bac. Some don't.

                                Keep looking. It's important to know it all. But rest assured, it's much easier to find the scary stuff--and attach to that, then it is to find the not-so-exciting just stuff, and stick with that. You'll be able to manage what you're taking, and how you feel. It's simply a medication.
                                :l
                                (If it makes you feel any better, I scared the pants off of myself reading all this stuff, and I made it!)

                                Comment

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