I can't find any via forum search or Google. Are there any issues with Bac and NSAIDs (Ibuprofen, Naproxen, Rx like Mobic, etc?
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Bac _ NSAIDs - any issues?
I believe that NSAIDS (non-steriod anti-inflammatory drugs) that are excreted by the kidneys (like ibuprofen) *can* cause baclofen blood levels to rise if your kidneys are over taxed. I've not taken any ibuprofen since starting baclofen just as a precaution. I can often take up to 2400mg+/day for various aches and pains.
Here's a link:
Baclofen toxicity associated with declining renal clearance after ibuprofen
PA Dahlin and J George
A 64-year-old male with an incomplete spinal cord injury had been taking baclofen 20 mg tid for 2 1/2 months without side effects. His blood urea nitrogen and serum creatinine rose from 13 and 0.9 mg%, respectively, to 59 and 2.8 mg% after ibuprofen 600 mg tid was begun. The patient displayed baclofen toxicity, developing confusion, disorientation, bradycardia, and hypothermia. His blood pressure dropped and he complained of blurred vision. Ibuprofen discontinuation and fluid repletion corrected the renal indices. Rapid tapering of baclofen was accompanied by reversal of baclofen toxicity. Patients taking baclofen must be monitored closely for toxicity when declining renal function is present. Clinicians should be alert to the possibility of renal insufficiency developing when ibuprofen is initiated. This case demonstrates the potential for ibuprofen-induced renal insufficiency to reduce baclofen clearance, thereby leading to baclofen toxicity. Published reports of ibuprofen-induced renal insufficiency are reviewed and pertinent pharmacokinetics of baclofen discussed.
Your mileage may vary.
-tk
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