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    First clinical test of Baclofen-results

    The first clinical trial of high dose of baclofen for treatment of alcohol dependence has been published in a medical journal (Ameisen O / R. de Baurepaire, Annales medico-psychological, January 2010). This test, which focused on 60 patients for whom conventional treatments had failed, demonstrating that high-dose baclofen suppresses alcohol dependence and consumption in 88% of these patients. The removal of alcohol dependence was described for the first time in the medical literature in 2004 by Prof. Ameisen that, based on animal models of addiction withdrawal, had managed to completely remove his own addiction to alcohol, self-administering high dose of baclofen. Since then the elimination of alcohol dependence using high-dose baclofen, has been reproduced and published in the medical literature and in hundreds of patients in Europe and the United States. As in animals, baclofen is, in humans, the only drug for which the complete elimination of the pathological desire to consume alcohol is established. Other drugs, naltrexone (naltrexone) and its derivative nalmefene (Revex), acamprosate (acamprosate, Campral), topiramate (Epitomax) etc ... only reduce the urge. The link to the medical article is:

    Suppression de la dépendance à l’alcool et de la consommation d’alcool par le baclofène à haute dose : un essai en ouvert - EM|consulte

    The results show that after three months of treatment, 88% of patients had completely stopped or significantly reduced their alcohol intake, and most of them have become indifferent to alcohol without effort. The doses of baclofen were required vary from one patient to another, ranging from 15mg/day to 300mg/day, with an average of 145mg/day. Approximately two thirds of patients required a dose greater than that permitted 80mg / d.
    BACLOFENISTA

    baclofenuk.com

    http://www.theendofmyaddiction.org





    Olivier Ameisen

    In addiction, suppression of symptoms should suppress the disease altogether since addiction is, as he observed, a "symptom-driven disease". Of all "anticraving medications used in animals, only one - baclofen - has the unique property of suppressing the motivation to consume cocaine, heroin, alcohol, nicotine and d-amphetamine"

    #2
    First clinical test of Baclofen-results

    totally effing awesome.
    Go before that fire there, at the altar of your heart
    That fire of who you really are and be consumed by it fully
    Surrender everything into the fire of that love until you are one with that love. You ARE that love.
    Tilak Pyle Altar of the Heart

    Comment


      #3
      First clinical test of Baclofen-results

      This is exciting news. I hope this means more people who need higher doses in the US will begin to be able to get them through their docs rather than .com pharmacies off shore. Of course I also hope this means more doctors will become educated about Bac as a treatment option.

      DG
      Sobriety Date = 5/22/08
      Nicotine Free Date = 2/27/07


      One day at a time.

      Comment


        #4
        First clinical test of Baclofen-results

        Kudos, Otter! Thank you for keeping abreast and for sharing here.
        And... FINALLY!
        eva

        Comment


          #5
          First clinical test of Baclofen-results

          Fantastic Ottor have been adviced by a health care professional to get some evidence and approach my gp in England to prescribe baclofen for me ( I need a minatanice dose of 75/100mg daily) you just provided me with just what I need to show my doctor ! Do you think we are finally getting there ?

          Comment


            #6
            First clinical test of Baclofen-results

            Otter just one thing how can I get to view the whole paper ? the link only goes to an abstract , any ideas ? This is very exciting !

            Comment


              #7
              First clinical test of Baclofen-results

              I'm so very happy to see this result.

              Now... I wonder how long it will take for this to become a mainstream treatment? I look forward to the day when courts, families and rehabs offer a Baclofen regimen as the most effective solution.

              ^

              Comment


                #8
                First clinical test of Baclofen-results

                This is great news, which should encourage more doctors to prescribe effective doses (i.e. beyond the current daily dose "limit" of 80 mg). Now if only a controlled-release form of baclofen could become available to overcome any problems caused by its very short half life!

                Comment


                  #9
                  First clinical test of Baclofen-results

                  Thank you Otter. You do keep abreast and quickly disseminate information to the benefit of all.

                  What I'm wondering is, why is this just coming out now, if the study was done in January?

                  Could it be related to the study being published in French? You would expect it to have been translated somewhere, seeing as French is not currently the most spoken language in the world, nor the standard for medical documentation (I think).

                  Could there be other reasons it has not been widely circulated, especially to addiction specialists?
                  Your time is limited, so don't waste it living someone else's life... And most important, have the courage to follow your heart and intuition. They somehow already know what you truly want to become. Everything else is secondary.

                  Steve Jobs, Stanford Commencement Adress, 2005

                  Comment


                    #10
                    First clinical test of Baclofen-results

                    Seems once again the veil of silence over al adicction decends. I really dont think the main body of medical specialists want to acknowledge that al addiction can be controlled by medication. Much easier to shake heads and point fingers at the poor hapless drunks who lack self control and will power ( are they the same thing ?). If this was a trail for any other kind of illness it would be headline ground breaking news !

                    Comment


                      #11
                      First clinical test of Baclofen-results

                      Absolutely fan-bloody-tastic!!!

                      Otter: many thanks for sharing the info with us

                      It is so encouraging to see that there is progress - even if it is at a slower pace than we all would liek to se.
                      I'll do whatever it takes
                      AF 21/08/2009

                      Comment


                        #12
                        First clinical test of Baclofen-results

                        beatle;943954 wrote:
                        What I'm wondering is, why is this just coming out now, if the study was done in January?
                        Hi Beatle,

                        This is typical. The peer review process for academic journals is glacially slow at times, sometimes due to a manuscript sitting on a reviewer's desk for a long time prior to review. Corrections and revisions also take time since they have to circulate back and forth.

                        Thanks for the link Otter. This will definitely go into my collection.

                        -wort
                        TSM started 1/22/2010; Wks 1-6: 78u/wk
                        Baclofen + TSM started 3/5/10; Wks 7-25: 52u/wk
                        Alcohol free and indifferent since 7/15/2010

                        Comment


                          #13
                          First clinical test of Baclofen-results

                          Wheeeeeee THANK YOU for this news Otter!

                          Comment


                            #14
                            First clinical test of Baclofen-results

                            I found it on the French site. The original article is by subscription but you can get the abstract by clicking Translate on Google. I hope it works for someone.

                            Here is the English version of the abstract:

                            Clinical Test Results - Baclofen UK
                            BACLOFENISTA

                            baclofenuk.com

                            http://www.theendofmyaddiction.org





                            Olivier Ameisen

                            In addiction, suppression of symptoms should suppress the disease altogether since addiction is, as he observed, a "symptom-driven disease". Of all "anticraving medications used in animals, only one - baclofen - has the unique property of suppressing the motivation to consume cocaine, heroin, alcohol, nicotine and d-amphetamine"

                            Comment


                              #15
                              First clinical test of Baclofen-results

                              Abstract

                              There is an English translation of the abstract of the article on Baclofen for Addiction - Baclofen UK. The original article is in French and you need a subscription to get it on the internet.
                              BACLOFENISTA

                              baclofenuk.com

                              http://www.theendofmyaddiction.org





                              Olivier Ameisen

                              In addiction, suppression of symptoms should suppress the disease altogether since addiction is, as he observed, a "symptom-driven disease". Of all "anticraving medications used in animals, only one - baclofen - has the unique property of suppressing the motivation to consume cocaine, heroin, alcohol, nicotine and d-amphetamine"

                              Comment

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