Dosage and Frequency

[susanna]

Dosage and Frequency

Update on my brother's binge stopper 30 mg/hour trial

Here's the update on my brother since a couple of hours ago:

I am detecting improvements. No consumption of vodka since 11 am, a few sips of beer.
Very emotional about being in this state, really wants to stop.

Dosage so far:
7:30 am: 40 mg
10:50 am: 30 mg ; cumulative total: 70 mg
11:50 am: 30 mg; cumulative total: 100 mg
1:10 pm: 30 mg; cumulative total: 130 mg
2:00 pm: 30 mg;; cumulative total: 160 mg
next dose - 3 pm

Titration up until today:
Sept 17-26: slow titration from 20mg -100 mg/day over nine days
Sept 26-30: 120 over 3 doses
Oct 1-5: 140 over 3 doses


For those who are concerned. my sister and I are here today on 24 hour watch with him to make sure he is safe. We (girlfriend, sisters, mom) have been on 24 hour watch with him for 12 days now and I feel this is his best day so far in terms of AL consumption.

I am very hopeful....

[Lo0p]

Dosage and Frequency

This, is kind of what I did my very first day of taking baclofen:

susanna;975169 wrote:
Dosage so far:
7:30 am: 40 mg
10:50 am: 30 mg ; cumulative total: 70 mg
11:50 am: 30 mg; cumulative total: 100 mg
1:10 pm: 30 mg; cumulative total: 130 mg
2:00 pm: 30 mg;; cumulative total: 160 mg
next dose - 3 pm

And Susanna, I am eagerly watching these updates.

I waited 1.5 hours between doses and assessed SE's. If they were bearable I'd take more.

My very first day I took 150 mgs.

My second day I took 250 mgs.

My third day I took 250 mgs.

You can see this in my graph:



I then took 250 for the next few days and then ran out of baclofen because I didn't order enough.

[susanna]

Dosage and Frequency

Wow - this is good to know!

What happened after you got more BAC - did you get back and stay on high dose for a while?

Lo0p;975206 wrote: This, is kind of what I did my very first day of taking baclofen:



And Susanna, I am eagerly watching these updates.

I waited 1.5 hours between doses and assessed SE's. If they were bearable I'd take more.

My very first day I took 150 mgs.

My second day I took 250 mgs.

My third day I took 250 mgs.

You can see this in my graph:



I then took 250 for the next few days and then ran out of baclofen because I didn't order enough.

[Lo0p]

Dosage and Frequency

[Otter]

Dosage and Frequency

PMs

I have posted some PMs. This thread is for real.

Those of us who have to watch our loved ones disappear into this disease will know how awful it is. I would never have posted what I did without it being advised and encouraged by a very senior qualified doctor with substantial experience with Baclofen.

This is an extremely serious illness which needs radical intervention at times. Many drugs have huge side effects but they have to be weighed against the risks of continuing to allow the illness to destroy the patient and his/her family.

Having been drinking steadily for weeks my wife is now sitting watching TV, AF, not craving, taking 10 mg per hour and wanting to stop drinking for good.

She has a way to go to get her health back but it seems to have worked.

[ignominous]

Dosage and Frequency

Thanks for the info Loop

The article about Naltrexone reinforces the CNS versus plasma half life theory. I was surprised and pleased to read how different it was. Conservatively around 10 times.

[muchthought]

Dosage and Frequency

WOW!!
Susanna, what a wonderful sister you are and what a great support system your brother has. I hope baclofen works right now, today and tomorrow. Please keep us posted.

And Loop thank you again for the graphs, so graphic ha, - such a graphic testimony of how well bac works.

WOW

[Seethepony]

Dosage and Frequency

Hey Otter, I didn't mean to sound so dismissive of your doc's recommendations. I was just recalling my toughest period with Baclofen and it was a horrific few hours during which I would have been cheesed off but not entirely surprised if I'd suddenly keeled over with a heart attack. So hearing about those kind of doses - without dosing up? - made my hair stand on end. (For the record, I used to consume beer and wine in ungodly amounts so the volume "1 liter" meant nothing to me - had you said vodka or whatever I'd have better understood the situation you were describing.)

Lo0p, wow - amazing graph -- dopey question: how did you do that?

And Susanna, like muchthought said, your brother's a lucky man to have a pair of sisters like you. I know that Baclofen is proven to be astonishingly safe - but for me the side effects were, for those few hours, truly alarming. So it's good to know your brother's in safe hands. Good luck!

[susanna]

Dosage and Frequency

I couldn't imagine letting my brother struggle through this on his own. It's a ILLNESS. Would we let a loved one with cancer figure it out and care for themselves?!!

Ok - here's where we are at:

Dosage so far:
7:30 am: 40 mg
10:50 am: 30 mg ; cumulative total: 70 mg
11:50 am: 30 mg; cumulative total: 100 mg
1:10 pm: 30 mg; cumulative total: 130 mg
2:00 pm: 30 mg; cumulative total: 160 mg
3 pm: 30 mg; cumulative total: 190 mg
4 pm: 30 mg: 30 mg; cumulative total: 210 mg
5 pm: 30 mg: 30 mg; cumulative total: 240 mg

Drinking very little - like a sniff of vodka and a partial beer. Moaning, feels "like ass", but gets up periodically to smoke - and now smoking a partial cig instead of 2 in a row with each sitting..... Having little cat naps - lasting 5-15 mins. At one point he listened to some of his fave music - and was REALLY, I mean REALLY, enjoying it. Is prone to the odd giggle now. Seems like he is having a bac high perhaps. Very wobbly on his feet - can't walk straight - as if he has downed 1/2 liter of scotch.

More later....

Seethepony;975336 wrote: Hey Otter, I didn't mean to sound so dismissive of your doc's recommendations. I was just recalling my toughest period with Baclofen and it was a horrific few hours during which I would have been cheesed off but not entirely surprised if I'd suddenly keeled over with a heart attack. So hearing about those kind of doses - without dosing up? - made my hair stand on end. (For the record, I used to consume beer and wine in ungodly amounts so the volume "1 liter" meant nothing to me - had you said vodka or whatever I'd have better understood the situation you were describing.)

Lo0p, wow - amazing graph -- dopey question: how did you do that?

And Susanna, like muchthought said, your brother's a lucky man to have a pair of sisters like you. I know that Baclofen is proven to be astonishingly safe - but for me the side effects were, for those few hours, truly alarming. So it's good to know your brother's in safe hands. Good luck!

[Otter]

Dosage and Frequency

Blood sugar levels

I forgot to mention, you might want to keep some bottles of Lucozade handy to drink to avoid any hypoglycaemic attacks from sugar lows as the alcohol level drops in the night after the first day. You might bring it all up but you don't want to go into some sort of rage and grab a bottle again.

[Topsy-Turvy-Tracy]

Dosage and Frequency

Susanna, sounds good so far. I'm thinking of you.

Loop, great graphs - what wonderful proof it is. Thanks.

[susanna]

Dosage and Frequency

Challenges tonight

Hi everyone:

So we're now at 300 mg. And his alcohol consumption may have declined too quickly today because he is experiencing strong withdrawals. High heart rate and very agitated, swearing and getting mad etc.

I've given him Gatorade and cookies as per Otter's suggestion to manage glucose levels. Also gave him Lorazepam - hoping that will bring him down soon- he's really uptight right now. Hoping the loraz kicks in soon. It's very stressful - he's winding up like crazy -aggressive. We're trying to calm and encourage him.

More later,
Susan

[Topsy-Turvy-Tracy]

Dosage and Frequency

Hope you are okay, Susanna, and your brother too. Don't be worried about calling an ambulance if he needs a medical detox. Keep yourself safe first - that's really important, for both your sakes.

[ignominous]

Dosage and Frequency

Thinking of you Susanna.

Is he continuing to take regular doses of Bac?

[Sunnyvalenting]

Dosage and Frequency

Be sure to take plenty of b vitamins, especially thiamine to avoid Wernike's encephalopathy which can occur when you stop drinking and start eating carbs such as juice or sugar drinks which is often the only thing we can keep down during withdrawal.
The withdrawal protocol which Dr. Aldolorato studied they only used 30 mg/day so these numbers sound outrageously high and possibly dangerous.
IMO:
If you need a medical detox see a doctor!
Good luck
sunny