Dosage and Frequency

[Lo0p]

Dosage and Frequency

ignominous;977326 wrote: Thanks for your opinion Loop
I'm not sure I'm even completely understanding the things that you're saying. Can you point me to the studies that you're referring to? I should be able to pull the full ones and send them back to you if you're just getting the abstracts off of pubmed. If you're interested that is.

Just off the top of my head, without seeing the literature actually in front of me, I think you might be confusing 'half life in the CNS' with 'half life in the CSF'. The cerebrospinal fluid, which is the target area (per se) for baclofen in the treatment of MS and related disorders. But again, I'd like to have a look at what you are reading.

susanna;977333 wrote: We were just discussing strategy for the evening and next couple of days. We were thinking along Ig's line that it might be time to coast for a while and let everyone recover from the intensity of the past 2 weeks, and stabilize. We seem to be out of the crisis-danger situation of a few days ago. We can take a slower pace and let his system settle in. The poor guy's been to hell and back, a few times, since 2 weeks ago. Taking a cue from LoOp`s experience, he may lose cravings entirely at this level in the next day or so.

Sounds good. If I were Paul I could probably really use a break right now. Sh!t...After the couple weeks he's had if I were him I'd want to sit back and crack open a cold one...or not. Yes, I am the king of bad jokes. :nutso:

[Topsy-Turvy-Tracy]

Dosage and Frequency

Hi Susanna,

I have deleted this post on the advice of a friend.

[Publius]

Dosage and Frequency

Susanna-
I feel a little silly posting this since I don't have all the back story. I am pretty new to posting here...long time lurker, short time contributor. I have been having trouble locating the origin of your troubles helping Paul with his Ameisen's Disease. I have, however, been intently paying attention to your plight of late, concerning your uber super detox regimen with him on bac, and I feel compelled to reiterate what many have already said. I just want to offer my respect for the courage that you have shown helping to fight your baby brother's disease, my admiration of your willingness to do what is necessary even in an unproven setting, my congratulations and thankfulness that your bravery has started to pay off, my continued prayers that life will be better very soon, and the knowledge that it will be, because though you have chosen an unbeaten path, the great risk will be greatly rewarded. Keep on doin what you do darlin; I'll be rooting for you every step, and give my best to Paul.
:getwell:

-Publius

[Topsy-Turvy-Tracy]

Dosage and Frequency

Publius, is that you in your avatar?

[Publius]

Dosage and Frequency

Tracy- I hear you but... her brother just went through a detox that I (as a 15-30 a night drinker) have never faced (I've been lucky, my DT's have never been that severe). I think you might wait a couple of days to wait for the treatment to do its thing before you start calling her clingly. for the record, I think those meds and that treatment is off the wall, but as it's been said, much to my disbelief as to the extent of this, people truly do have seriously different tolerances to even what are considered serious meds.

[Lo0p]

Dosage and Frequency

I'm trying really hard not to give advice, because I'm in no position to do so. But I have to agree with everyone at this point, and yourself and say that I think it is time to take it easy.

The aside that I'm having with Ig here in this thread has nothing to do with what's going on with your brother. At least I don't think it does.

[Topsy-Turvy-Tracy]

Dosage and Frequency

We interrupt this post to bring you a moment of quiet.

[Publius]

Dosage and Frequency

that would be the late great winston churchill I'm a much more youthful 24

I just want to clarify that I've learned the blunt way that no matter what I consider to be my own extreme experience, while we all have a common enemy, our individual experiences can be vastly different, much to the dismay of my preconceived notions (and I tend to be stubborn in those). Hell when I was drunk I let out a diatribe on what I felt baclofen would logically accomplish given its nature as a drug, and Ig wrote me back negating my beliefs, and on further research I realized he was right, and begrudgingly I changed those beliefs...now I have to physically stop myself from spouting my gut beliefs, because I've realized those can be misguided, if not completely unfounded. Knowledge is a fickle little bastard, you can have it, but if what you knew changes, by definition you never had it in the first place

[Publius]

Dosage and Frequency

Sorry tracy, it takes me forever to write, so I didn't get that last one til right now, and I feel like you and I are necessarily on a different page when it comes to the whole letting go thing, I just feel like it may be way to soon to be bringing that up... If it's still an issue after he gets to a position where he actually can take care of himself, then we add 3 weeks, then maybe we'll have a new thread for letting go of afflicted loved ones, but I think this injection is a tad premature

[Lo0p]

Dosage and Frequency

I :h open minded people... :l

[susanna]

Dosage and Frequency

A response to Tracy's comments

Topsy-Turvy-Tracy;977381 wrote: Hi Susanna,

He's at a really flippin' high dose. I would not add more or give him more during the night at this point.

Whatever you all are thinking about SE's is sort of irrelevant at this point. From what you've posted, you have plenty of meds to deal with sleeplessness.

I reiterate: He's on a really flippin' high dose. If the bacoflen does what it is supposed to do, he's not going to need you anymore. How do you feel about that?

Love ya much, but I know a fellow codie when I see one.

What do you think about the idea of slowly backing away and letting your brother take his own life back?

Hugs (seriously),

Tracy - I hear the language of a veteran AA-er - Codie? Are you flippin' kidding me?! If he was dying due to a diabetic seizure would you suggest we all walk away and let him handlle it?!!

For the record - he is an active participant in this program - do you think we have him duct taped to a chair and are force feeding him a diet of beer and bac?

To suggest I define my worth by Paul 'needing' me is transparent psycho-babble. Paul and I live separate and independent lives. He's in a fight for his life right now. Pardon me while I help my brother, at his request, with this program.

As to dose levels - please refer to data shared by various people who have taken similar approaches, and succeeded. We didn't just dream this up, it's based on the experience of others, including a UK doctor with much experience using baclofen for alcoholism.

Sorry but I really felt your comments needed a candid response like this - I would not want other readers to be frightened away and end up dead from their final binge. People here have a right to know that there are various paths to the end-goal; not just the slow-easy-does-it-path. Just like cancer or any other potentially fatal disease and, as Otter said, it's a serious disease; it requires sometimes more aggressive measures.

[susanna]

Dosage and Frequency

Paul update

He's calm, relaxed, comfortable, optimistic. He's watching TV - an old western on Turner Classic Movies channel. He's not moaning, or suffering, other than wanting to fall asleep.

He's had 370 mgs bac today over 17 hours in doses ranging from 20-30 mgs an hour.

He has not hit his switch but that's ok - it will come. His consumption of beer is low - less than one an hour.

[Lo0p]

Dosage and Frequency

susanna;977400 wrote: His consumption of beer is low - less than one an hour.

:wd:

Tell him to have one for me, k? :H

[susanna]

Dosage and Frequency

Ba da boom

Will do - I've been reading your comments to him LoOp - and others' comments to him. He knows there's a group following his progress.

I'm sharing this progress, btw, for others to know about, and know the range of options that may be available to them, or people they care for.

Lo0p;977402 wrote: :wd:

Tell him to have one for me, k? :H

[sapphire1]

Dosage and Frequency

Hi Susanna

I have just got onto this thread and reading back would just like to offer my praise and respect for what you, your family and your brother are doing. What an amazing person you are....what a loving and supportive family Paul has to fight for him tooth and nail and not back away when the going gets tough. I had to do the same thing for my darling son, who for eight years suffered with a psychotic illness. I took many risks and went against conventional wisdom to find answers for him......much to the chagrin of many who thought I should just back off and let him suffer. Long story short, today he is a sane and very healthy young man with his whole life before him. If people dont jump into the fire with this beast, lives will be lost. I will watch Pauls journey with compassion and hope that he too will reclaim his life. More power to you and your family Susannah...love Saffyx