Bac in the News re: GERD

[Topsy-Turvy-Tracy]

Presented at the 75th Annual ACG meeting:

"In this study, we found that bacolfen significantly reduces the amount of waking which occurs after the onset of sleep," said Dr. Orr. "Baclofen addresses the physiological causes of reflux, by preventing the relaxation of the lower esophageal sphincter and preventing the stomach acid from entering the esophagus. Few drugs inhibit the occurrence of reflux and 40 to 50 percent of those taking PPIs don't get satisfactory relief, especially at nighttime,"

Baclofen reduced the number of reflux events compared to a placebo (4 events vs. 1.3). Patients on baclofen also had more sleep time (434 minutes vs. 379 minutes) and greater sleep efficiency (91 percent vs. 79 percent), according to the study. "The results of this study suggest that baclofen could be a useful adjunct therapy to proton pump inhibitors in patients with nighttime heartburn and sleep disturbance," said Dr. Orr.

Studies Show Heartburn Has a Significant Impact on Sleep

[Sunnyvalenting]

Bac in the News re: GERD

Tracy, Do you know the dose they were using in their study? The article doesn't say.
S

[Isolde]

Bac in the News re: GERD

I can attest to this first hand! Now that I'm back on a decent dose of bac, that odd constant heartburn feeling that I was experiencing is gone. Prevacid had helped somewhat, but didn't cause it to disappear completely.

And as for the increased sleep time and sleep efficiency? Absolutely yes! :H

Thanks for posting this Trace.

[Topsy-Turvy-Tracy]

Bac in the News re: GERD

Sunny, I looked at the short write up on ACG site and didn't find the dose there either.

Isolde, I had the reflux pretty much under control anyway, but I'm right with you on the increased sleep time and sleep efficiency. I wake up feeling actually rested and ready to get out of bed. Part of that probably has a lot to do with not waking up hungover though.