Haven't read the whole thing but here's the abstract--hope it's helpful! xoxo Pride
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Research Report
Topiramate for the Treatment of Alcohol Dependence: Comparison with Naltrexone
Gerardo Fl?rez, Pilar A. Saiz, Paz Garc?a-Portilla, Sandra ?lvarez, Luis Nogueiras, Julio Bobes
Eur Addict Res 2011;17(1):29-36.
Background: A 6-month naturalistic, randomized and open-label, trial of topiramate versus naltrexone was conducted, with assessments at enrollment and after 3 and 6 months of treatment. 182 alcohol-dependent patients who had been drinking heavily during the past month were included. Methods: Outcome was measured using tools that assessed alcohol intake, cravings, disability, and quality of life; changes in biomarkers of alcohol intake were also used. Results: At the 6-month evaluation, patients taking topiramate had significantly lower scores on the OCDS (all subscales), the EuropASI (medical, alcohol, family/social, and psychiatric) and the WHO/DAS (employment/social). More patients taking topiramate remained in the abstinence group and the moderate drinking without problems group. Conclusions: Topiramate at a mean dose of 200 mg/day was better than naltrexone at a mean dose of 50 mg/day at reducing alcohol intake and cravings throughout the study.
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Research Report
Topiramate for the Treatment of Alcohol Dependence: Comparison with Naltrexone
Gerardo Fl?rez, Pilar A. Saiz, Paz Garc?a-Portilla, Sandra ?lvarez, Luis Nogueiras, Julio Bobes
Eur Addict Res 2011;17(1):29-36.
Background: A 6-month naturalistic, randomized and open-label, trial of topiramate versus naltrexone was conducted, with assessments at enrollment and after 3 and 6 months of treatment. 182 alcohol-dependent patients who had been drinking heavily during the past month were included. Methods: Outcome was measured using tools that assessed alcohol intake, cravings, disability, and quality of life; changes in biomarkers of alcohol intake were also used. Results: At the 6-month evaluation, patients taking topiramate had significantly lower scores on the OCDS (all subscales), the EuropASI (medical, alcohol, family/social, and psychiatric) and the WHO/DAS (employment/social). More patients taking topiramate remained in the abstinence group and the moderate drinking without problems group. Conclusions: Topiramate at a mean dose of 200 mg/day was better than naltrexone at a mean dose of 50 mg/day at reducing alcohol intake and cravings throughout the study.
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