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    #76
    Indifference.

    wow! good suggestions. thanks.
    And point taken, about remembering. but pffft, anyway. You switch people full of sagacity and humor. v. annoying, I don't mind telling you.

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      #77
      Indifference.

      I am available for wisdom, sagacity and humour in chat...

      Comment

        #78
        Indifference.

        Hmmm, it seems my robust internet connection isn't up to the demanding task of an internet chat...

        Comment

          #79
          Indifference.

          Makes sense -- but lots of people can't actually do that (every 2 hours). Another big problem is for people who have their sleep disturbed by baclofen, like me. I have to taper way down in the evening, in preparation for the sleeplessness and the weird side-effects. Then again, if I just didn't drink, I could just take the pills, and then deal with the sleeplessness in other ways. (other pills?)

          Anyway, I agree that the more often/spread out your doses are, the better chance of success.
          Your time is limited, so don't waste it living someone else's life... And most important, have the courage to follow your heart and intuition. They somehow already know what you truly want to become. Everything else is secondary.

          Steve Jobs, Stanford Commencement Adress, 2005

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            #80
            Indifference.

            beatle, why couldn't anyone do every 2 hours? Amytriptiline is your friend!

            Comment

              #81
              Indifference.

              Ukblonde;1050577 wrote: Or you could just give yourself an enema.
              That's an option. But the great thing about the salt water flush is that it goes through the whole length of your intestines, which I imagine is pretty crucial when you've been backed up for 5 days! Enemas can only go so far up.
              Better Living Through Chemistry

              Switched at 180mgs of Baclofen on 1/31/11, and again on 10/8/11 at 200mgs.

              Could've been a swan on a glassy lake, could've been a gull in a clipper's wake. Could've been a ladybug on a windchime, but she was born a dragonfly.
              ~Clutch

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                #82
                Indifference.

                bleep;1050691 wrote:
                Baclofen has a short half life...
                In case of chronic dosing t1/2 increases to ~ 6.5 hours (pharmacokinetics at steady state).

                Comment

                  #83
                  Indifference.

                  Dosing/half life of baclofen

                  bleep;1050726 wrote: beatle, why couldn't anyone do every 2 hours? Amytriptiline is your friend!
                  Many people on this thread have indicated that it is difficult for them to take it even every 4 hours because of work. Not sure why. Dr. L. does recommend spread-out doses, more often than less often, but he recommended 4 hour intervals to me, not sure why -- maybe for convenience?

                  From Pharmaceutical Monograms:

                  "Peak plasma concentrations of baclofen are achieved within 2 hours and the plasma half-life is 2 to 4 hours"

                  RxMed: Pharmaceutical Information - LIORESAL

                  This would make me think bleep's schedule is logical. However, it may be be that since the half life is 4 hours (which is what I've always heard before), 4-hour intervals would make sense, so there is always overlapping that keeps the bac in the system in a constant manner, without the peaks and valleys we have discussed previously? IOW, maybe every 2 hours means you would have overlapping peaks (with half peaks), meaning the peaks would actually be 1.5 in magnitude of a 4-hour peak?

                  Yeh, I know, this probably sounds like nonsense, but can you guys just try to get into my head for a minute? It's so tiring to have to put my thoughts into words (another bac SE).

                  Anyway, I'm going to try bleep's dosing schedule and see how it works. (But I don't work in an office.)
                  Your time is limited, so don't waste it living someone else's life... And most important, have the courage to follow your heart and intuition. They somehow already know what you truly want to become. Everything else is secondary.

                  Steve Jobs, Stanford Commencement Adress, 2005

                  Comment

                    #84
                    Indifference.

                    In case of chronic dosing t1/2 increases to ~ 6.5 hours (pharmacokinetics at steady state). Elimination of baclofen from the brain is much slower than it's elimination from the blood, resulting in more stable and persistent CNS levels (Spasticity: Disordered Motor Control. Chicago: Year Book Medical, 1980, pp 461-475).

                    Comment

                      #85
                      Indifference.

                      Call me old fashioned, enemas just aren't my scene. If it came to that, it would definitely be self-administered, I can't imagine getting someone to do that for me :wow: The SWF sounds a lot more pleasant. On that note, it seems to have resolved itself without any intervention, from me or anyone else, which is unbearably pleasant to report.

                      beatle, good luck, I hope you see some results. Please let us know how you get on. What has been your dosage schedule up to now?

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                        #86
                        Indifference.

                        Sober, thats interesting, thanks. If I'm reading it right, that just reinforces the theory?

                        Comment

                          #87
                          Indifference.

                          Yes Bleep, they can indeed be self-administered.

                          Comment

                            #88
                            Indifference.

                            I-want-to-be-sober;1051016 wrote: In case of chronic dosing t1/2 increases to ~ 6.5 hours (pharmacokinetics at steady state). Elimination of baclofen from the brain is much slower than it's elimination from the blood, resulting in more stable and persistent CNS levels (Spasticity: Disordered Motor Control. Chicago: Year Book Medical, 1980, pp 461-475).bleep;1051054 wrote: Sober, thats interesting, thanks. If I'm reading it right, that just reinforces the theory?
                            In fact it points out that very frequent dosing is probably not necessary, because the half-life increases if baclofen is taken regularly and CNS levels drop slower than blood levels.

                            Sober

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                              #89
                              Indifference.

                              Ah, ok, thanks. I can see 37 shaking his head in despair...

                              Comment

                                #90
                                Indifference.

                                I-want-to-be-sober;1051076 wrote: In fact it points out that very frequent dosing is probably not necessary, because the half-life increases if baclofen is taken regularly and CNS levels drop slower than blood levels.

                                Sober
                                That's something close to what I was sort of trying to maybe postulate (in my ever-so-articulate way)

                                I know, the 1.5 magnitude thing might have been a little over the top...
                                Your time is limited, so don't waste it living someone else's life... And most important, have the courage to follow your heart and intuition. They somehow already know what you truly want to become. Everything else is secondary.

                                Steve Jobs, Stanford Commencement Adress, 2005

                                Comment

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