I downloaded a paper today "Evidence-Based Treatments of Addiction" by Charles P. O'Brien (and I cannot reproduce here due to copyright). I had hoped it would say something helpful about baclofen. It only said that bac showed promised based on a study we already knew about. The interesting part was this: I had ordered modafinil in order to counter the side effects of somnolence and lack of focus produced by baclofen, so I was surprised to find modafinil written up as a promising treatment all it's own for cocaine. I am reproducing this part of the paper, and if someone comes and kicks my butt for it, so be it:
"Another recent novel approach involves modafinil, a drug that produces alerting via a complex mechanism involving enhanced glutamate activity. As mentioned in paragraph, BLOCKADE OF EUPHORIA, modafinil partially blocks cocaine-induced euphoria in the laboratory. In a randomized clinical trial, Dackis reported that modafinil-treated subjects significantly reduced their use of cocaine when compared with placebo-treated subjects (Dackis et al. 2005). Modafinil is currently under intense investigation as a potential first-line treatment for cocaine dependence . . . Given these findings, the pharmacological reversal of cocaine withdrawal symptoms with agents such as modafinil may improve clinical outcome (Dackis et al. 2005)."
My thought is that if modafinil can successfully counter the side effects of high dose baclofen - and can produce an anti-craving effect of it's own, this could be a boon to a to me and maybe others. I know nothing about medicine, it's possible side effects, contraindications, or other risks and am NOT posting this as advice or suggestion, merely as something to think about. The full paper is available here:
Evidence-Based Treatments of Addiction -- O'Brien 9 (1): 107 -- Focus
My modafinil probably won't be here for another week or two. I'll post an update about how it effects me.
"Another recent novel approach involves modafinil, a drug that produces alerting via a complex mechanism involving enhanced glutamate activity. As mentioned in paragraph, BLOCKADE OF EUPHORIA, modafinil partially blocks cocaine-induced euphoria in the laboratory. In a randomized clinical trial, Dackis reported that modafinil-treated subjects significantly reduced their use of cocaine when compared with placebo-treated subjects (Dackis et al. 2005). Modafinil is currently under intense investigation as a potential first-line treatment for cocaine dependence . . . Given these findings, the pharmacological reversal of cocaine withdrawal symptoms with agents such as modafinil may improve clinical outcome (Dackis et al. 2005)."
My thought is that if modafinil can successfully counter the side effects of high dose baclofen - and can produce an anti-craving effect of it's own, this could be a boon to a to me and maybe others. I know nothing about medicine, it's possible side effects, contraindications, or other risks and am NOT posting this as advice or suggestion, merely as something to think about. The full paper is available here:
Evidence-Based Treatments of Addiction -- O'Brien 9 (1): 107 -- Focus
My modafinil probably won't be here for another week or two. I'll post an update about how it effects me.
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