Consolidated Baclofen Information Thread
Hi Lo0p
Following up. You have already posted the very important and influential Addolorato article from 2002 on this thread:
BACLOFEN EFFICACY IN REDUCING ALCOHOL CRAVING AND INTAKE: A PRELIMINARY DOUBLE-BLIND RANDOMIZED CONTROLLED STUDY
Addolorato has done a follow up study which reinforces his earlier findings and supports dose responsive efficacy. This study was published earlier this year (2011) in Alcohol and Alcoholism and I'm not aware that it has been posted anywhere else on the forum. In any event, here's the link:
Dose–Response Effect of Baclofen in Reducing Daily Alcohol Intake in Alcohol Dependence: Secondary Analysis of a Randomized, Double-Blind, Placebo-Controlled Trial
BTW, while this paper supports the efficacy of baclofen treatment, Dr Ameisen took issue with it because Addolorato said that anecdotal evidence (including Ameisen's) has shown that baclofen can reduce craving. Dr Ameisen responded that his evidence shows not that baclofen can reduce craving, but that baclofen can suppress craving.
Here is a link to an extract of Dr Ameisen's letter:
Baclofen: What's in a Word? A World of Difference
Dr Ameisen's letter led to a thoughtful response from Dr Addolorato, where he carefully evaluated the evidence whether baclofen reduces or suppresses craving. An interesting response. Here's the link:
Response to Ameisen
I'm sure most of us will take either one, reduce or suppress, so long as the monster is slain!
And also, Lo0p, thanks very much for all your constructive efforts on this board. They are very much appreciated.
Cassander
Lo0p;1177772 wrote: Thank you all for your contributions. I should edit all of this into the original post. If someone would show me, or rather, take up the responsibility of housing all of this information on a website that more than one person has control of, then it would be updated faster and could be edited by more than someone like me. I don't feel comfortable with deciding alone what should go up there.
Following up. You have already posted the very important and influential Addolorato article from 2002 on this thread:
BACLOFEN EFFICACY IN REDUCING ALCOHOL CRAVING AND INTAKE: A PRELIMINARY DOUBLE-BLIND RANDOMIZED CONTROLLED STUDY
Addolorato has done a follow up study which reinforces his earlier findings and supports dose responsive efficacy. This study was published earlier this year (2011) in Alcohol and Alcoholism and I'm not aware that it has been posted anywhere else on the forum. In any event, here's the link:
Dose–Response Effect of Baclofen in Reducing Daily Alcohol Intake in Alcohol Dependence: Secondary Analysis of a Randomized, Double-Blind, Placebo-Controlled Trial
BTW, while this paper supports the efficacy of baclofen treatment, Dr Ameisen took issue with it because Addolorato said that anecdotal evidence (including Ameisen's) has shown that baclofen can reduce craving. Dr Ameisen responded that his evidence shows not that baclofen can reduce craving, but that baclofen can suppress craving.
Here is a link to an extract of Dr Ameisen's letter:
Baclofen: What's in a Word? A World of Difference
Dr Ameisen's letter led to a thoughtful response from Dr Addolorato, where he carefully evaluated the evidence whether baclofen reduces or suppresses craving. An interesting response. Here's the link:
Response to Ameisen
I'm sure most of us will take either one, reduce or suppress, so long as the monster is slain!
And also, Lo0p, thanks very much for all your constructive efforts on this board. They are very much appreciated.
Cassander
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