Weight/dose correlation

[Otter]

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[bleep]

Weight/dose correlation

?

I was under the impression that it was pretty conclusively not linked to weight?

[Otter]

Weight/dose correlation

That seems to be the answer I have from others. Ameisen in his book took the weights of rats and their doses and extrapolated that to get his switch dose. I suppose it is just an individual thing. Trial and error.

[Lo0p]

Weight/dose correlation

terryk;1152481 wrote: Otter- only about 15% of the baclofen one ingests is metabolized by your liver, the rest is filtered out of your blood by your kidneys and excreted unchanged in your urine.

Otter, he speaks the truth...your kidneys, not your liver, are mainly responsible for removing baclofen from the bloodstream.

[Otter]

Weight/dose correlation

The point then is that is about how much your system absorbs, which depends on kidneys and liver, as opposed to weight.

It just seems to me that people here are going a lot higher than just 140mg a day to hit the switch. Despite having some of the top doctors we seem not to be able to get them to do this properly. I shall have to have a think about it. Thanks for the responses. End of thread.

[bleep]

Weight/dose correlation

Otter;1157081 wrote: End of thread.

I disagree. I'd like to clear something up that's been puzzling me for a while. When they say "excreted unchanged" does this mean the kidneys don't actually do anything, they just filter it out of your blood. In other words, does it tax your kidneys?

[Cassander]

Weight/dose correlation

Otter;1156998 wrote: ... Trial and error.

Speaking of trial and error, does anyone have definitive information regarding the status of the clinical trials being conducted at the University of Amsterdam? Or is this the kind of thing where there is no information until a report is published...

Thanks

[_serenity_]

Weight/dose correlation

There is absolutely no correlation between weight and switch dose, IMHO. NE and I are the same age and weigh the exact same amount, and we both have crazy-high tolerances for alcohol (i.e. we've both been known to drink a case of beer a day). And yet I "switched" at 190 mg/day and she was up to over 300 when she hit her switch. There is no factor yet discovered that determines the switch dose.

I should add that some males (i.e. Seethepony) have "switched" at far lower doses than NE or me.

[_serenity_]

Weight/dose correlation

Cassander, that study is still ongoing and we won't hear any word on the results for some time.

[Ne/Neva Eva]

Weight/dose correlation

Cassander;1157184 wrote: Speaking of trial and error, does anyone have definitive information regarding the status of the clinical trials being conducted at the University of Amsterdam? Or is this the kind of thing where there is no information until a report is published...
Cass- The last I heard it wasn't slated to actually begin studying anybody until this fall. They were gathering specimens. (people. lol)
There's an article around here, on the old Consolidated Bac Thread, I think, with some info. You might be able to get more by googling the major players. I can't do it now, but maybe you or someone can locate the article?

_serenity_;1157284 wrote: There is absolutely no correlation between weight and switch dose, IMHO. NE and I are the same age and weigh the exact same amount, and we both have crazy-high tolerances for alcohol (i.e. we've both been known to drink a case of beer a day). And yet I "switched" at 190 mg/day and she was up to over 300 when she hit her switch. There is no factor yet discovered that determines the switch dose.

I should add that some males (i.e. Seethepony) have "switched" at far lower doses than NE or me.

Hiya Serenity! :h

Yep, Otter. I'm not sure that as a group we are an accurate predictor for dosing, but regardless the 'switch' dose is all over the place, and that IS accurate. We've also been exploring relationships with alcohol post-indifference. That, too, varies a great deal.