Baclofen absorption possibly reduced if taken with meals

[Greg]

I'm not sure if this has already been covered somewhere on the forum, but am posting it in case not. It's written by the University of Maryland Medical Center:

Phenylalanine may reduce absorption of baclofen (Lioresal), a medication used to relieve muscle spasms. Avoid taking Baclofen with a meal, especially one that is high in protein, or with phenylalanine supplements.

Link to relevant University of Maryland Medical Center page

I only noticed this by chance while reading about phenylalanine, and don't know enough to add any opinion of my own (not even sure if this is actually relevant in practice).

[bleep]

Baclofen absorption possibly reduced if taken with meals

Thanks for the heads up Greg. It's not something I've seen before.

[Ne/Neva Eva]

Baclofen absorption possibly reduced if taken with meals

Hey, Greg. Interesting stuff, thanks.

I think this sentence has some relevance:

If you are currently being treated with any of the following medications, you should not use phenylalanine without first talking to your health care provider.

Baclofen -- Phenylalanine may reduce absorption of baclofen (Lioresal), a medication used to relieve muscle spasms. Avoid taking Baclofen with a meal, especially one that is high in protein, or with phenylalanine supplements.

It seems to me that if you don't have this disease, and if you're not taking this particular amino acid, you can take bac with food. I could be wrong, though.

This part is also interesting:

The body changes phenylalanine into tyrosine, another amino acid that's needed to make proteins, brain chemicals including L-dopa, epinephrine, and norepinephrine, and thyroid hormones.

I think I'd be very careful about taking related amino acids with baclofen in case they too affect the absorption.

There are quite a number of MWOers who take lots of amino supps with their bac...

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[treetops]

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