Dr Ameisen: I will no longer post on MWO!

[Bill.P.]

Dr Ameisen: I will no longer post on MWO!

Hey Olivier, dont worry on that stuff, no loss, I dont post on MWO for the very same reason,

However, wanna check out an even more amazing baclofen combo. Just sent 2 days ago, way better than baclofen alone. This will blow your socks off, I guarantee it, get back to me via email, I have a feeling it got lost in your inbox.

Bill.P.

[terryk]

Dr Ameisen: I will no longer post on MWO!

Bill.P.;1179376 wrote: Hey Olivier, dont worry on that stuff, no loss, I dont post on MWO for the very same reason,

However, wanna check out an even more amazing baclofen combo. Just sent 2 days ago, way better than baclofen alone. This will blow your socks off, I guarantee it, get back to me via email, I have a feeling it got lost in your inbox.

Bill.P.

Hey Bill.P. these aren't the words of a big-league, competent professional with qualified medical training, they sound more like the snake-oil salesman who sells a busted monorail to Springfield on "The Simpsons"

http://www.youtube.com/watch?v=AEZjzsnPhnw[/video]]Simpsons - Monorail - YouTube

"The name's Lanley. Lyle Lanley. And I come before you good people tonight with an idea. Probably the greatest... Aw, it's not for you. It's more of a Shelbyville idea."

Just sayin',

tk

p.s. if your magical, mythical drug "combo" can erase my horrific financial debt I *might* be interested, otherwise you can't make me *more* indifferent to alcohol and I'm not suffering any side-effects from baclofen at 200+mg/day after a year of sobriety.

[terryk]

Dr Ameisen: I will no longer post on MWO!

Bill.P.;1179376 wrote: Hey Olivier, dont worry on that stuff, no loss, I dont post on MWO for the very same reason,

However, wanna check out an even more amazing baclofen combo. Just sent 2 days ago, way better than baclofen alone. This will blow your socks off, I guarantee it, get back to me via email, I have a feeling it got lost in your inbox.

Bill.P.

Hey Bill, I think I found the combo you were talking about:

CGP7930: a positive allosteric modulator of the... [CNS Drug Rev. 2007] - PubMed - NCBI

CGP7930: a positive allosteric modulator of the GABAB receptor

Adams CL, Lawrence AJ. Department of Pharmaceutical Biology, Victorian College of Pharmacy, Monash University, Australia.

Abstract CGP7930 (3-(3',5'-Di-tert-butyl-4'-hydroxy)phenyl-2,2-dimethylpropanol) is a positive allosteric modulator of the metabotropic GABAB receptor. CGP7930 has been found to modulate the GABAB receptor in the open, or high affinity, state increasing agonist affinity for the receptor and signal transduction efficacy following agonist stimulation. The GABAB heteromeric subunit B2, involved in signal transduction but not ligand binding, seems to be the site of action of CGP7930 and similar allosteric modulators. When administered alone in na?ve animals, CGP7930 acts as an anxiolytic in rodents without other overt behavioral effects and has also been demonstrated to reduce self-administration of nicotine, cocaine, or alcohol in rodents, suggesting that "fine tuning" of the GABAB receptor by positive allosteric modulators may be able to regulate abuse of these drugs. Baclofen, the GABAB agonist, is currently finding use in treating addiction and various other disorders, but this can result in off-target effects and tolerance. CGP7930 when co-administered with baclofen enhances its potency, which could in theory minimize deleterious effects. Further study of CGP7930 is required, but this compound, and others like it, holds potential in a clinical setting.


MID: 17894647 [PubMed - indexed for MEDLINE]

Probably won't cure my financial woes, but sounds promising nonetheless, thanks for sharing it with us here (oh wait......)

-tk

[missyabby1]

Dr Ameisen: I will no longer post on MWO!

Hey Terry K. Good work! What an exciting find. It is obviously getting closer to the "right" medication for us all! And it is coming out of Oz! Even better!

Missy x

[dazed]

Dr Ameisen: I will no longer post on MWO!

redhead77;1178747 wrote:
Dazed, I don't want to kick you when you are clearly feeling down, but the fact that you took his thread and threw a huge temper tantrum is unfortunate. You did it right after he said he wouldn't be back, demanding answers.

No, actually I made my initial post hours before he posted his dramatic exit. Within that period of time, he went from being fairly to cohesive to fairly incoherent. That kind of decline through the course of a day could be due to many things, alcohol abuse, the long-term effects of alcohol abuse, Alzheimer's, and mental illness among them. What I am certain about is that it is not an effect of baclofen itself. I did get the information I was looking for.

Thanks for the invitation but I'm really not interested. I know what the conundrum is. I already know what the various suggestions would be - go up in dose, go down in dose, take smaller doses, take it all at once at night, don't take it at night, take supplements, take other medications to counter the side effects and so on. I have reduced my dose to a level where I feel competent enough to take on the rapidly approaching mid-terms. What frightens me is that I was on the edge of having to drop below 12 credits, which have cost me my funding and my ability to continue college. I am not going to take that risk again.

Best wishes to all.

[Ne/Neva Eva]

Dr Ameisen: I will no longer post on MWO!

dazed;1180631 wrote: No, actually I made my initial post hours before he posted his dramatic exit. Within that period of time, he went from being fairly to cohesive to fairly incoherent. That kind of decline through the course of a day could be due to many things, alcohol abuse, the long-term effects of alcohol abuse, Alzheimer's, and mental illness among them. What I am certain about is that it is not an effect of baclofen itself. I did get the information I was looking for.

Thanks for the invitation but I'm really not interested. I know what the conundrum is. I already know what the various suggestions would be - go up in dose, go down in dose, take smaller doses, take it all at once at night, don't take it at night, take supplements, take other medications to counter the side effects and so on. I have reduced my dose to a level where I feel competent enough to take on the rapidly approaching mid-terms. What frightens me is that I was on the edge of having to drop below 12 credits, which have cost me my funding and my ability to continue college. I am not going to take that risk again.

Best wishes to all.

You're rather prickly aren't you? So you know all the advice, and I'm not going to spout aphorisms or admonitions. Too much of that going around anyway. I'll tell you this: Whatever you could do drunk, you'll do better sober.
Take the damn pills. I don't care how, or under what circumstances. Gobbling them by the fistful doesn't seem to work over the long term. But whatever.
I'm back in school, having unsuccessfully returned to school many, many times. Diagnoses ranged from clinical depression to ADHD long before that was a fad. It's all bull shit. I was a drunk from the first drink, and school got in the way.
I just got the highest grade in the class on an exam in a class that 30% of the students who started have dropped out. Bac didn't just offer sobriety, it's given much more than that.
Get to the other side, Dazed. The clarity is astounding.
And the next time you visit, rather than disparaging those of us who have made this a priority, a thank you would be in order. Or did you figure it all out on your own?
I would add that I don't give a good god damn about what you think of Dr. Ameisen on a personal level, but that you, like all of us, owe him the fact that HE wrote the book. Those of us that take the pills and find the goal owe him our sobriety. Those of you who get your priorities straight and follow behind will do the same.
A little respect would be in order. For all of us.
Good luck on your midterms.

[RedThread12]

Dr Ameisen: I will no longer post on MWO!

uuuhhh . . . well said, Ne!

[Cinders]

Dr Ameisen: I will no longer post on MWO!

Rousseau was a brilliant educator and writer about raising children. He also made his "wife" (maybe girl friend, not good at my history) give all of them up for adoption.

However, his writings on educating children are instrensick (sp? It looks horrible to my eyes) to what all schools in the Anglo/Saxon world today use.

I learned a long time ago that great thoughts do not necessarily come from great men. (Please remove the gender from your thoughts, I am old school. If I speaking about a pool of people, I use the male gender. That is not accepatable today but it was back in my "day.")

Great thoughts are what they are. No matter where they come from.

Not saying Dr. Amiesen isn't great, just expressing my opionion that whether he is or isn't is moot.

Love,
Cindi

[dazed]

Dr Ameisen: I will no longer post on MWO!

Ne/Neva Eva;1180687 wrote: You're rather prickly aren't you? So you know all the advice, and I'm not going to spout aphorisms or admonitions. Too much of that going around anyway. I'll tell you this: Whatever you could do drunk, you'll do better sober.
Take the damn pills. I don't care how, or under what circumstances. Gobbling them by the fistful doesn't seem to work over the long term. But whatever.
I'm back in school, having unsuccessfully returned to school many, many times. Diagnoses ranged from clinical depression to ADHD long before that was a fad. It's all bull shit. I was a drunk from the first drink, and school got in the way.
I just got the highest grade in the class on an exam in a class that 30% of the students who started have dropped out. Bac didn't just offer sobriety, it's given much more than that.
Get to the other side, Dazed. The clarity is astounding.
And the next time you visit, rather than disparaging those of us who have made this a priority, a thank you would be in order. Or did you figure it all out on your own?
I would add that I don't give a good god damn about what you think of Dr. Ameisen on a personal level, but that you, like all of us, owe him the fact that HE wrote the book. Those of us that take the pills and find the goal owe him our sobriety. Those of you who get your priorities straight and follow behind will do the same.
A little respect would be in order. For all of us.
Good luck on your midterms.

I don?t want to keep doing this, and this discussion is a good example of why I do not want to be an active participant here.

I have disparaged no one. Unless you are talking about Ameisen, and I don?t think I even disparaged him. I was really insistent upon an answer, and I got one, but that?s not the same thing as being degrading to someone. Who have I degraded? If you are talking about the ?advice? that I already know, it was not my intent to ?disparage? anyone. There is simply no new information, obviously since you offered none.

Congratulations on your success in college! While a 30% drop-out rate would be a conservative average in a freshman-level class, it is unheard of in upper-level classes. As you probably know, depending on your college, they are incredibly difficult to schedule as they generally are offered only once per school year if you are lucky. Some are only offered once every two years. I had to drop one, which put me right at 12 credits with no more room spare for Baclofen brain-fry. I am dependent on scholarships so taking lesser grades is not an option.

What is your major? What is your dose? I was much higher functioning drinking than I was not drinking and on 200 mg of Baclofen. I do not think you are suggesting that my experience is deviant from the norm. The posts I have read here would suggest otherwise.

As far as ?respect? for Ameisen goes, I do not feel impelled to respect him. Nothing you or anyone else could say would likely make me feel otherwise. He did what he did to save himself and made whatever profit he made from his book, which I have never read. He obviously wants to profit more. Good for him, but that does not command my respect. You and everyone else here came here hoping to somehow personally benefit. Good for you too.

As far respecting anyone else here, I do not believe that I have disrespected anyone. I think that your terse reprimand was very disrespectful. I have ignored a couple of name-calling posts from people here that were certainly disrespectful. That did not surprise me since I have read many rude things posted here, but I am not standing here DEMANDING respect.

Please think about this next question and try to envision how you see yourself and how you see this place.

Who do you think you are to demand respect from me?

As for clarity, I think that I am doing okay in that respect, whether you think so or not.

If you would like to end this exchange now, please do. I have little time for it and really no heart for it.

[Ne/Neva Eva]

Dr Ameisen: I will no longer post on MWO!

You are in a really difficult place, Dazed. I wish you the best.

[terryk]

Dr Ameisen: I will no longer post on MWO!

dazed;1180755 wrote:
I have disparaged no one. Unless you are talking about Ameisen, and I don’t think I even disparaged him.
To be fair, you did. Recall:

dazed;1178007 wrote: Really? 530 mg per day and zero side effects? Really? Tell me, Dr. Ameisen, are you ever worried that the studies that you toot are going to expose you as the liar that you are? Does it ever occur to you that the WORST thing that could happen to your "lifetime achievement" is the studies that you toot?
and:

dazed;1178389 wrote:
I debated about whether to use “liar” or “delusional,” and selected the former because I thought the apparently ego-driven doctor might be more likely to respond. I suspect that the other might hit too close to home.

also:
dazed;1178389 wrote:
I have ignored a couple of name-calling posts from people here that were certainly disrespectful.

You used a really childish ploy to provoke Dr. Ameisen into giving you information you wanted on your terms. It was disrespectful and it was trollish. I called you out on that.

dazed;1178007 wrote:
If you would like to end this exchange now, please do. I have little time for it and really no heart for it.

No one is forcing you to post here, and no one is forcing you to take baclofen.

I also wish you the best,
-tk

[Otter]

Dr Ameisen: I will no longer post on MWO!

I agree!

I also don't think what Dr. Ameisen said shows him to be either a liar or delusional. Justifiably annoyed, perhaps. What he is saying is that who are any of us here, in truth, to be giving out medical advice, particularly when it gives the impression that, for instance, 300mg a day is the answer, simpliciter with no explanation. The starting point is to read the book. He is a doctor; his self study was published in a reputable scientific journal and he is advising other doctors on prescribing Baclofen. He is in a unique position to understand the treatment professionally and personally. He is in touch with people from all over the world who are involved in this study at the highest professional and governmental level. What he was saying was that we should be trying to point people toward getting proper medical advice, which, still, is hard to get and the authoritative guide in Baclofen treatment is still his book. Saying, here, as a non medical professional, anything about dosage is actually quite mad when you think about it.

If Baclofen grows exponentially and there are, after just a few years of his book's publication, 10 or 50 thousand people using it in France alone and a government backed study there, what will it be like in another couple of years? The prediction in early news articles was that this medication will become the treatment of choice for alcoholism regardless of trials. It really is an unstoppable force. This may save millions of lives and improve the quality of lives for millions more.

Some of the comments here leave me speachless. If someone does not respect a person for initiating that, what does it say about them? Who can one respect?

As for writing a book and making money, I suppose the same criticism could be levelled at all sorts of people such as WELCOME TO MAHATMA GANDHI ONE SPOT COMPLETE INFORMATION WEBSITE and A Long Walk to Freedom: The Autobiography of Nelson Mandela: Amazon.co.uk: Nelson Mandela: Books and Barack Obama Books

Oh, and don't forget this one, In 1947 Life magazine called Albert Schweitzer, “the greatest man in the world." He wrote books! Lots of them Albert Schweitzer: books by Albert Schweitzer @ BookFinder.com. And this lady wrote books too Books

Since when has writing a book been something to use to abuse the author? What kind of person, particularly one who is at university, would disparage someone for writing a book?

Sometimes you have to step back from this site and think about what is going on here and what role you/we are playing in all this and what kind of an impression things we say give to others, not just about ourselves, but about Baclofen as a treatment.

I think "Heal Thyself", is a very good caution to people coming here who want to call others "liars" and disparage the good things that they have done. And where are the rules about posting. I thought one of them is to stop before you post and think about what it is that you are saying before pushing the post button.

[Ne/Neva Eva]

Dr Ameisen: I will no longer post on MWO!

LOL, Otter. Sort of. I know you don't mean to be funny, and I'm not laughing at you. But if thinking before posting was a rule, I think it's fair to say 90% of what's written here wouldn't be posted. Hell, I was drunk for the first 10 months. Most of us are, when we start.

Much as I'd like to venture into the fray, that's all I've got. (though it's kiiillllllllinnnnnnnnggggg me.)

[Ne/Neva Eva]

Dr Ameisen: I will no longer post on MWO!

CINDERS!
AF! Congratulations! It's very nice to *see* you around, and even better that you're well on the way. Wow! That's so great!

[Murphyx]

Dr Ameisen: I will no longer post on MWO!

Dr Ameisen was the first to figure out the connection between alcohol and baclofen and he wrote a book about it. He didn't write a new fucking bible. He isn't a god......well not to me anyway.