Taking one dose of Bac only at night??

[bostonguy92]

Throughout my back and forth phenibut addition/withdrawls, I have experimented with Baclofen only a bit. It seemed to give me positive effects (decrease withdrawl symptoms) as well as negative ones (brain fog, fatigue).

I am now COMPLETELY kicking phenibut out of my life and will be shifted only to baclofen. Since it gives me brain fog and feeling fatigue, could I only take baclofen at night, in one dose? I hear that most take it 3-4 times per day.

Any advice would be greatly appreciated.

[ifulovelife2]

Taking one dose of Bac only at night??

As I understand it, baclofen dissipates fairly quickly with a short half-life of 8 (?) hours. However, HDB increases the half life to 24 plus hours, so when you get up to the higher doses and you've been on them a while you should be bale to take it once a day without any probs.

That all said, I may be misremembering and if I am, I'm sure someone will be along in a minute to correct me.

[bostonguy92]

Taking one dose of Bac only at night??

What is HDB?

[RedThread12]

Taking one dose of Bac only at night??

High Dose Baclofen

[Bminor]

Taking one dose of Bac only at night??

I'm pretty sure Lo0p used to slam 200mg once daily... maybe he can chime in here.

[Lo0p]

Taking one dose of Bac only at night??

Yeah, I used to do 200-300 mg once daily at like 2pm. It worked great for me for quite a while until my work schedule got all messed up (nights then days, back and forth). Tip, I think still takes his dose once a day. 80ish mgs.

[bostonguy92]

Taking one dose of Bac only at night??

Thanks LoOp. What side effects should I expect taking a large dose at one time? I'm guessing that I should take it at night before bed? If so, would it decrease the fatigue/sleepiness during the day time?

[Lo0p]

Taking one dose of Bac only at night??

Who knows? SE's to baclofen are a very individual thing.

How did you normally take phenibut?

[terryk]

Taking one dose of Bac only at night??

As I understand it, baclofen dissipates fairly quickly with a short half-life of 8 (?) hours. However, HDB increases the half life to 24 plus hours, so when you get up to the higher doses and you've been on them a while you should be bale to take it once a day without any probs.

Baclofen generally has a short half-life of ~1.5 - 4 hours with peak plasma baclofen level 1-2 hrs after ingestion of dose. It has been observed that with chronic baclofen administration, the half-life can jump up to ~6-7 hours.

This study in the: https://www.mywayout.org/community/f2...ml#post1112161 details some specifics. Interestingly, peak plasma levels/troughs between individuals varied *greatly.* Two important quotes: "Clinical experience had shown wide variation in effective baclofen dosages between individuals," and "nonlinear relationships between baclofen level and dose frequently occur, with unexpected increases and decreases in blood levels." Examples to the second quote suggest that someone with low baclofen clearance could theoretically maintain a high baclofen plasma level for much longer than you'd expect for a 1,4, or even 6 hour half-life - (24hrs?).

Your mileage may vary. Good Luck. -tk

[tiptronic_ct]

Taking one dose of Bac only at night??

I started taking a once-daily dose, but only months after becoming indifferent to alcohol. Whilst titrating up, it is best to maintain as even a level in your system as possible by splitting your doses.

[Lo0p]

Taking one dose of Bac only at night??

Only you can really tell what'll work and you'll know it (or think you do) when it doesn't. Baclofen is funny that way.

If you have a very addictive personality, do you other drugs of choice? Try baclofen the best way we know how (which isn't the way I did it, but it worked). By titrating up slowly until you find that you are free of all of your addictive tendencies.

I've read of experiences on other forums (bluelight comes to mind) where people successfully tapered off of phenibut (and other gaba-ergic substances) using baclofen.

But they've only scratched the surface IMO as to baclofen's full potential, to free yourself of all your addictions.

[Greg]

Taking one dose of Bac only at night??

Hey Bostonguy, do you mind me asking what sort of problems you ran into with phenibut? I'm curious to know if it was mainly physical withdrawal symptoms, or if it was also (or only) psychological dependence. Did you find that tolerance became a serious problem with the substance? Sorry if this sounds too personal, and I'll understand if you prefer not to answer. I'm just trying to understand phenibut a bit better, without actually doing too many experiments with it myself. I have a very addictive nature too, having had major problems with alcohol and marijuana, so I'm a bit too wary of getting involved with phenibut in a regular or heavy manner.

Good luck overcoming your problem.

[bostonguy92]

Taking one dose of Bac only at night??

I took Phenibut all at once and loved the effects. I never had a Phenibut "hangover".

[bleep]

Taking one dose of Bac only at night??

I take my baclofen in one go these days, which is 260 or 270mg's, depending on how things are going. This is for convenience more than anything else, and I've found it to be effective, despite what I know about the half-life. As to how this can be, I'm not sure. Terry, any thoughts?

If you are starting off on baclofen, it's not an approach I'd recommend. Splitting the dose during titration has been found to help reduce the SE's. Once you're happy at a level that works for you, experiment with changing how you take it.

My 2 cents...

[Cassander]

Taking one dose of Bac only at night??

It has been mentioned and bemoaned numerous times on this site, but someday, when bac is a recognized and accepted treatment, there will be time release baclofen tailored in different doses for use by alcoholics.