Taking one dose of Bac only at night??

[bostonguy92]

Taking one dose of Bac only at night??

Greg,

I don't mind answering any questions you may have about Phenibut. That is why we are all here, right? To pass on our pro's/con's and results. As much as I LOVED the effects of Phenibut, I would never recommend it to you or anyone else. The saying "If it seems to good to be true, it probably is", applies to Phenibut 100%.

I have been off and on Phenibut for about 6 months and tell myself each and every time, it is the last. I have done many "substances" in the past and have never become addicted, until Phenibut. On it, I feel on top of the world. More energy, focus, motivation, libido, desire to interact with everyone, etc. After six days of continued use (2-3 grams/day), I have extreme anxiety, depression, racing heartbeat, panic attacks, paranoia, insomnia, no appetite, no motivation, body aches, etc. This is all, even, if I take a dose that day. I see how people get up to 7-10 grams/day.

It is a vicious cycle and is both physical and psychological to the extreme.

[Bminor]

Taking one dose of Bac only at night??

That's crazy. Phenibut didn't do jack shit for me.

[tiptronic_ct]

Taking one dose of Bac only at night??

I didn't know what Phenibut was, so I did a cursory search. The wikipedia entry mentions that withdrawal symptoms are similar to that of baclofen.

[bostonguy92]

Taking one dose of Bac only at night??

Yes, I have heard the same thing about the withdrawl similarities. The difference is that baclofen doesn't have the tolerance issues that phenibut does, from what I understand.

[Greg]

Taking one dose of Bac only at night??

bostonguy92;1217294 wrote: Greg,

I don't mind answering any questions you may have about Phenibut. That is why we are all here, right? To pass on our pro's/con's and results. As much as I LOVED the effects of Phenibut, I would never recommend it to you or anyone else. The saying "If it seems to good to be true, it probably is", applies to Phenibut 100%.

I have been off and on Phenibut for about 6 months and tell myself each and every time, it is the last. I have done many "substances" in the past and have never become addicted, until Phenibut. On it, I feel on top of the world. More energy, focus, motivation, libido, desire to interact with everyone, etc. After six days of continued use (2-3 grams/day), I have extreme anxiety, depression, racing heartbeat, panic attacks, paranoia, insomnia, no appetite, no motivation, body aches, etc. This is all, even, if I take a dose that day. I see how people get up to 7-10 grams/day.

It is a vicious cycle and is both physical and psychological to the extreme.

I felt immune to fear during one phenibut experiment, due to the massive confidence boost it gave me. But what you have said here has convinced me not to get involved with it any further. It sounds worse than most other drugs, when 6 days of use can cause all the problems you had. Obviously it has properties beyond its GABA-B and -A agonism. I recall reading that it's supposed to boost dopamine levels, and also phenylethylamine I think (my memory may be faulty with that however). My impression is that it's a fairly unknown substance, due to not being used medically in most countries.

[Ne/Neva Eva]

Taking one dose of Bac only at night??

bostonguy92;1216567 wrote: Since it gives me brain fog and feeling fatigue, could I only take baclofen at night, in one dose? I hear that most take it 3-4 times per day.

Any advice would be greatly appreciated.
I wouldn't take it that way if your goal is freedom from addiction(s). Not to start. There was one guy who titrated up that way, but only after having been on it for a good long while. He went all the way down and then back up again with a one-dose-schedule.
bleep's been taking it since, what? December 2010?
Lo0p for much longer.
Tip for even longer.

If your goal is just to get off the phenibut, I'd have no idea.

Cassander;1217272 wrote: It has been mentioned and bemoaned numerous times on this site, but someday, when bac is a recognized and accepted treatment, there will be time release baclofen tailored in different doses for use by alcoholics.

There was an extended release formula tested by some pharma company in Texas within the last couple of years! (And in relation to alcoholism!!!) I found it on our friend Google, but didn't save it. Obviously no results were published, creeps that they are.

bostonguy92;1217341 wrote: Yes, I have heard the same thing about the withdrawl similarities. The difference is that baclofen doesn't have the tolerance issues that phenibut does, from what I understand.

Phenibut sounds dreamy. I've never really liked or been attracted to any drug other than alcohol, but I had a similar experience with...being "on" and just at my very, very, very best for a while on HDB. I miss it enough to know that I will never, ever touch Phenibut.

There IS a thread around here about this, too. If you use the advanced search and look for Phenibut in the title you should find it. Hope those guys are okay.

[terryk]

Taking one dose of Bac only at night??

bleep;1217264 wrote: I take my baclofen in one go these days, which is 260 or 270mg's, depending on how things are going. This is for convenience more than anything else, and I've found it to be effective, despite what I know about the half-life. As to how this can be, I'm not sure. Terry, any thoughts?

It's a personal theory that I have that baclofen's anti-craving mechanism is part of a bigger, longer acting chain of chemical signaling that (only) starts at the relatively short acting GABAb receptor site (which is still actually hundreds (thousands?) of times longer acting than GABAa sites). Two ideas that jibe with that theory (to me) are: 1)In my experience, a change in dose takes a couple of days to really take effect, i.e. I was at my switch dosage for 2-3 days before I actually felt that I had made it. Similarly, when ever I titrate down below 240 to 220, It takes several days before I start feeling the cravings creep back in. 2) The literature outlines that Baclofen withdrawal takes around 1-4 days to set in after abrupt cessation with the longer durations of onset corresponding to higher daily doses (iirc).

Still, the idea that anyone could pop 200mg+ at a time without their head exploding has seemed pretty unbelievable to me. Then again, lately I've been able to double up after a missed dose and take 120mg with not too many problems, it's happened twice. I guess if you don't get side effects, you don't get side effects.

[bleep]

Taking one dose of Bac only at night??

Thanks Terry.

Baclofen definitely takes about 4 days to seep into your soul after changing doses. Ignominious (is he still around?) posted a useful interactive graph many moons ago for subutex, I think it was, which showed the effect clearly. Obviously it's a different drug, but the principle remains.

As to side effects from a large dose, I think after a while of taking baclofen your body and brain adjust to it. Some quicker than others, but I would imagine everyone gets there eventually. Maybe some other longish-term users could chime in? Personally I haven't felt a side effect for ages, except of course for not being a raging alcoholic!

[Cassander]

Taking one dose of Bac only at night??

Ne/Neva Eva;1217497 wrote:
There was an extended release formula tested by some pharma company in Texas within the last couple of years! (And in relation to alcoholism!!!) I found it on our friend Google, but didn't save it. Obviously no results were published, creeps that they are.

Hi Ne. Good memory. Here is a link to the clinical test:

ALK29-002: A Study of Baclofen Formulations in Healthy Adults - Full Text View - ClinicalTrials.gov

Alkermes is conducting numerous trials with Naltrexone, including extended release Naltrexone, but apparently nothing else with baclofen. Here is a link to all of the trials they have underway:

Search of: alkermes - List Results - ClinicalTrials.gov

[ifulovelife2]

Taking one dose of Bac only at night??

bleep;1217807 wrote: Maybe some other longish-term users could chime in? Personally I haven't felt a side effect for ages, except of course for not being a raging alcoholic!

Right from the start (01/2011) I got terribly tired in the evenings, as in suddenly falling asleep whilst, eating, talking, shagging, walking or peeing. I went up to 350/d and the same thing happened. Now I'm on 100/d and still the same. No other SEs, just suddenly falling asleep at the drop of a hat. I intend to come off it entirely, I wonder if that particular SE will remain. I kinda suspect it will; this is a powerful and strange drug, which we don't fully understand.

[terryk]

Taking one dose of Bac only at night??

Cassander;1217272 wrote: It has been mentioned and bemoaned numerous times on this site, but someday, when bac is a recognized and accepted treatment, there will be time release baclofen tailored in different doses for use by alcoholics.

I think the most promising future therapy for alcohol addiction will be the prodrug arbaclofen placarbil (or similar) + some new positive allosteric modulators that are currently being investigated:

* Baclofen is only absorbed in a small part of the GI tract, which makes extended release formulations problematic, plus it contains equal parts of the therapeutically active and inactive enantiomer (which may be responsible for side effects).

*Arbaclofen on the other hand, is absorbed all along the GI tract and then converted to the therapeutically active R-baclofen (without S-baclofen) throughout the body by it's own metabolism. This should decrease the fluctuations in baclofen plasma level and decrease the amount of doses of medication one would have to take every day.

* Positive allosteric modulators are chemicals that enhance baclofen's potency which might allow for a lower effective daily baclofen dose (with less side effects): CGP7930: a positive allosteric modulator of the... [CNS Drug Rev. 2007] - PubMed - NCBI

-tk