LSD for alcoholism?

[Bruunhilde]

LSD for alcoholism?

Ah Anne, you reminded me why I'm drinking dandelion tea, to cleanse! Its terrible stuff unless you like smoked wood tea.

[anne1232]

LSD for alcoholism?

Yeah, I really wory about all the folks here doing these huge amounts of Baclofen without kidney support......down the line, who knows? and of course we alkies need to be taking the Milk Thistle...

[terryk]

LSD for alcoholism?

anne1232;1254519 wrote: Yeah, I really wory about all the folks here doing these huge amounts of Baclofen without kidney support......down the line, who knows? and of course we alkies need to be taking the Milk Thistle...

Hello anne - Just curious, why do you worry about folks on high dose baclofen without kidney support? People with spinal cord injuries (for instance) have been taking hdb for decades and there isn't any mention in the medical literature that baclofen causes renal damage (even in instances of acute and sometimes massive overdose). It's true that people with existing renal insufficiency can experience baclofen toxicity, but that doesn't mean it's the baclofen that's at fault in the equation. Interestingly enough, in my search to find any damning evidence on the matter, I found this article (below) that says baclofen can actually protect kidneys from damage. Admittedly, it's a special circumstance - resumed blood flow after a stroke - and the article more mentions the role of GABAb receptors (in the CNS, not sites in the kidney), and not baclofen exclusively, but hey.....)

-tk

Renoprotective effects of gamma-aminobutyric... [Eur J Pharmacol. 2009] - PubMed - NCBI

Eur J Pharmacol. 2009 Nov 25;623(1-3):113-8. Epub 2009 Sep 16.
Renoprotective effects of gamma-aminobutyric acid on ischemia/reperfusion-induced renal injury in rats.
Kobuchi S, Shintani T, Sugiura T, Tanaka R, Suzuki R, Tsutsui H, Fujii T, Ohkita M, Ayajiki K, Matsumura Y.
Source

Laboratory of Pathological and Molecular Pharmacology, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan.
Abstract

Enhanced renal sympathetic nerve activity during ischemic period and the renal venous norepinephrine overflow after reperfusion play important roles in the development of ischemic acute kidney injury. We investigated the effect of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter mainly in the central nervous system, on ischemia/reperfusion-induced acute kidney injury in anesthetized rats. Ischemic acute kidney injury was induced by clamping the left renal artery and vein for 45min followed by reperfusion 2weeks after the contralateral nephrectomy. Intravenous injection of GABA (10 and 50micromol/kg) to ischemic acute kidney injury rats dose-dependently suppressed the enhanced renal sympathetic nerve activity during the renal ischemia, the renal venous norepinephrine overflow after reperfusion and attenuated the ischemia/reperfusion-induced renal dysfunction with histological damage. Intravenous injection of CGP52432 (0.1micromol/kg), a selective GABA(B) receptor antagonist, eliminated the preventive effect by GABA (50micromol/kg) on ischemic acute kidney injury. In contrast, intravenous injection of baclofen (1micromol/kg), a selective GABA(B) receptor agonist, attenuated the ischemia/reperfusion-induced renal injury equivalent to GABA (50micromol/kg). These results indicate that GABA prevents the development of ischemia/reperfusion-induced acute kidney injury presumably via GABA(B) receptor, by suppressing the enhanced renal sympathetic nerve activity during ischemia and the increased norepinephrine overflow from renal sympathetic nerve ending.

[anne1232]

LSD for alcoholism?

Thanks!!

Very interesting research. Just wanted to know that the Bac community has considered this, good to know you have, and with a good prognosis!

[terryk]

LSD for alcoholism?

anne1232;1254549 wrote: Very interesting research. Just wanted to know that the Bac community has considered this, good to know you have, and with a good prognosis!

Had my creatinine checked recently. It's a-okay and I've been on hdb for almost 2 years, and at/over 240mg/day for a year and a half. I'll let you know if my kidneys fall out. -tk

[anne1232]

LSD for alcoholism?

re Ibogaine

check out PBarE 's story..."The Trip of a Lifetime" here on MWO

[Ne/Neva Eva]

LSD for alcoholism?

anne1232;1254871 wrote: check out PBarE 's story..."The Trip of a Lifetime" here on MWO

Just ftr, he didn't get or stay sober. Not from baclofen, which he stopped taking because he was erroneously concerned about safety. Definitely not from ibogaine, which he did despite the risks. He now considers the only way to get sober is from the 12 steps. And that is in spite of the fact that he'd been sober/clean in AA for years before he started baclofen. Please see his most recent post for more info.

[GingerDust]

LSD for alcoholism?

I'm concerned. He stopped taking baclofen because he was concerned about safety. Did that concern have anything to do with ibogaine therapy? I think that actually is a concern if I am understanding what I have been reading.

If he's going back to what kept him clean and sober for years, maybe that is not a bad thing for him. I don't know. I haven't read his last post, but clean and sober for years would be a huge deal for me. It would the hugest thing that ever happened to me.

I have come to believe that addiction is not one thing. It is many things. The causes, the damage and the treatment paths are as individual as each of our life paths are individual, as unique as all of us are. I no longer believe that quality sobriety comes in fell swoops, from a single source. I think it is a very complicated thing that is very deeply rooted in human nature, not in the kind of "brain chemistry" that can simply be corrected by ingesting baclofen.

Just my opinion.

[anne1232]

LSD for alcoholism?

Read PBarE' latest. He is in fact sober, as of Dec. '11, for a year, he says. Yes, there are many paths. I merely posted his Ibo story for anyone curious about the experience. I certainly don't mean to make claims that any particular path is a cure all for everyone. Not at all. I'm thrilled for all the happy Bac people, and antabuse people, AA people, etc. Whatever works. We were discussing "other meds" here...just more tools for the arsenal.

[anne1232]

LSD for alcoholism?

more great Gabor Mate

http://www.youtube.com/watch?v=ScP2tIJJ2BA&feature=youtu.be[/video]]Dr. Gabor Maté: Ayahuasca and the Treatment of Addiction - YouTube

[GingerDust]

LSD for alcoholism?

anne1232;1254950 wrote: Read PBarE' latest. He is in fact sober, as of Dec. '11, for a year, he says. Yes, there are many paths. I merely posted his Ibo story for anyone curious about the experience.

I looked at his post. He said he did baclofen, that it gave him a good kick start and he'd do it again. He said he did ibogaine at the 6 month mark and planned to do it again after the first of the year. "It was a real difference maker." He loves his 12 step groups too. Good for him.

[GingerDust]

LSD for alcoholism?

I'm pretty sure that I'm hooked up with a facilitator. I trust the source. Talked to the hubby guy about it. He is all for it but wants to stand guard in case . . . I dunno. From what I understand, anyone witnessing the therapy sees a person who is asleep (unless they wake to puke, which is a common thing).

I still don't have specifics from my facilitator, but I'm pretty sure that this is going to happen for me. I know that the best case scenario is that the actual experience is not unpleasant. The worst (given that I'm in very good health) is that it's very unpleasant. It shouldn't matter though because it's not about comfort or even the trip itself. The value comes later. I'm excited and I'm scared. The lyrics for "Major Tom" keep running through my head, and the possibilities that the song expresses.

http://www.youtube.com/watch?v=BEG7OzvSMBA[/video]]Major Tom (Coming Home) Peter Schilling - YouTube

Home could be me, my own self, what I really am and what ibo is supposed to tap into to. Home could also be the scary place I grew up in.

Excited and scared. Yep, that pretty much sums it up.

[Bruunhilde]

LSD for alcoholism?

I was rereading these posts and thought about the puking part of the ibogaine experience. Anne, you didn't puke but you also didn't puke on the whale watching boat, which I greatly admire (and envy). When I went on an 8 hour whale watch, I puked the entire 8 hours. I would guess you're not a puker, that you purge in other ways. Me, I purge in all directions, LOL

Also curious about your dosage, did you have a flood dose? Did you do ibogaine HCI or the root?

I know you were thinking of doing it again, did you?

Really great thread, thanks.

[suneelca]

LSD for alcoholism?

Bruun, your post makes me wanna ...

[Bruunhilde]

LSD for alcoholism?

Sun, you'll feel so much better after.

:H