I do not have any health effects from long-term usage of baclofen. From an exercise perspective, I can perform heavy weight lifting without issue, although when I am tired, my coordination suffers a bit. Baclofen affects me much like it did 2 years ago, although I am now very familiar with the side effects, and find it relatively easy to cope/compensate. Once I'm used to a dose (takes me about 2 weeks to adjust,) the SEs are minimal, and mostly involve daytime somnolence.
I recently had blood work done, and while my physician is unaware of my HDB usage, my blood work checks out normal (and is actually much improved from previous tests due to weight loss.) Kidney function was fine.
Ask me anything about being on HDB for 2+ years :-)
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