Baclofen and relationship to GHB

[MusiciansMallet]

Baclofen and relationship to GHB

ignominious;1348156 wrote: Got to say Ne's synopsis made me chuckle.



OK, my version of dumbing it down:

A) Similar action on GHB receptor - Could conceivably cause dopamine.

B) Result of GABA b stimulation. We don't know. - Could result in dopamine.

C) Unknown reactions, You, I and we don't know. - Could result in dopamine.

No, baclofen has no known activity whatsoever at GHB receptors (& this has been investigated); sorry if I made this confusing by how I worded it. And, not to mention, stimulating GHB receptors is not pleasurable or something one would want either for medical purposes or recreational value.

Baclofen (or GHB) action as an agonist at GABA-b (err, "activating" or "stimulating") has no known effect on dopamine. Although there may be a secondary effect, which I personally suspect; meaning a domino type effect as a result of GABA-b activation (hard to explain w/o going into too much jargon). OR, these "rushes" (i got it when i FIRST started using baclofen) are a specific result of activity AT GABA-b subunit receptor (all receptors have different "kinds" or "types"... these are subunits. We really don't know if baclofen or GHB has "stimulates" one subunit over another; whereas with GABA-a drugs, we know that ambien & related drugs JUST "activate" or "stimulate" alpha-1 subunits, or "types", of GABA-a receptors; whereas benzodiazepines generally affect alpha1, 2, 3, 5, and 6... which is why they help with more symptoms than just sleep, unlike ambien or lunesta, or other related Z-drugs)

[ignominious]

Baclofen and relationship to GHB

ignominious;1347730 wrote: love to be educated by the likes of Mallet, who clearly has a lot of knowledge in this area.

Take it back

[MusiciansMallet]

Baclofen and relationship to GHB

ignominious;1348474 wrote: Take it back

awww c'mon now :upset:
tried to be nice! :H
You were pretty much on though, except for the GHB-receptor thing. Only GHB & related GHB drugs like GBL & GVL (and some research drugs) are agonists at GHB; although, there is some inquiry as to cocaine, amphetamines, cathinones (and other dopamine- and noradrenaline- releasing agents) activity in agonizing--err, stimulating--the GHB receptor at higher doses (causing nasty side effects like convulsions, tremor, seizure..)

[ignominious]

Baclofen and relationship to GHB

Hi MM. I'm not known as being "nice" but I'm glad you took it without getting bent out of shape.

My own pet theory, fwiw,

The brain is the most complex thing in our universe by definition. Everything that you know or percieve about the universe comes to you via your brain.
The brain has a lot of things going on in it
Despite this, it works as a single unit

Therefore: a tiny change in a tiny part of the brain will affect the complete unit

Conclusion: Maybe for me, feeling completey relaxed and at ease with life, the universe and everything gives me a great a dopamine rush. Something akin to being given a standing ovation after a 20 minute speach.

Its my theory. Ha! :H

[MusiciansMallet]

Baclofen and relationship to GHB

Therefore: a tiny change in a tiny part of the brain will affect the complete unit

....exactly my point when i said it may have a "secondary effect" on dopamine. If you perceive an experience as pleasurable, then dopamine is released (whether you're having sex or downing a small shot of GHB & you perceive the experience as pleasurable; or whatever)... Although, I was referring to a more complex secondary, domino effect... there just isn't any direct affinity for dopamine among gaba-b agonists- that's why they're not stimulants, antipsychotics, or tryptamines/phenethylamines (err, psychedelics)

& i'm never one to take sh*t overtly personally.. unless, well.. its personal; or if i'm literally insulted & its a cheap shot. Life is too short ...no, instead, i take may anger out on petty things; like being violent with my microwave, when it's not heating my food properly