Has anyone heard of STX209 or Arbaclofen?

[TexasAg]

I was researching Baclofen and autism and ran across this article:

New Version of an Old Drug Could Treat Autism (and Addiction Too) | TIME.com

From the Article:
"What Is Baclofen ? and STX209?
Like many drugs, baclofen contains two types of its main molecule, which are mirror images of each other. Often, one is an active ingredient, while the other is not. STX209, also known as arbaclofen, contains only the ?right-handed? molecule of baclofen, the drug?s active component. (More on Time.com: Building a Bridge to My Autistic Son: A Father?s Photo Journey)

According to Carpenter, STX209 is about 10 times more potent than baclofen. In mice with a genetic mutation similar to the one that produces Fragile X in humans, Seaside?s research found that the baclofen?s left-handed molecule did not have the same effect as STX209 and, in fact, actually increased anxiety-related behavior."


Anyone know anything about this Arbaclofen?

Loop? Anyone?

Cheers!

[agassizii]

Has anyone heard of STX209 or Arbaclofen?

Hey Tex,

I found some related research on the different isomers of bac. Isomers, as I understand the situation, are the same molecule but "mirror images" of one another. So one isomer turns to the left and the other to the right. It seems like the L- isomers are usually the biologically active forms. That's why you hear about L-glutamine and other amino acids for example, but you never hear about D-glutamine.

Bac as commonly available apparently consist of approximately equal amounts of L-baclofen and D-baclofen.

I ran across this issue when I had a weird side effect when I was titrating up.

I kept hearing this low frequency sound in the early morning when it was quiet in the house. Every morning. It sounded like a diesel engine idling. Or maybe a locomotive engine idling in the distance. But I kept hearing it every morning, looked around the neighborhood, and ruled out any possible source of the sound.

Then I got scared and thought it might be an auditory hallucination. After looking through some posts here, I found others who described this kind of low frequency diesel noise and ascribed it to auditory hallucinations.

So I researched on the net and found all kinds of weird conspiracy theory stuff, e.g. the Taos hum.

As it turns out the most plausible explanation was tinnitus. I always thought tinnitus only manifested as a high-pitched ringing in the ears, but there is a body of medical literature describing a number of different sounds as tinnitus, including that "diesel idling" noise. So that was a relief...at least I wasn't nuts!

Ironically there is some research into using bac as a treatment for tinnitus. But the only isomer that is effective as a treatment for tinnitus is the L- isomer.

That begs the question if the same is true for bac as a treatment for al.

This whole isomer issue could raise some interesting questions: Are the some of the side-effects people report a result of the D- isomer in medical bac? What would be the benefit of pure L-bac? Does this have anything to do with some people finding different effects with different brands?

Anyway, I hope this story might put some folks at ease when they realize they aren't hallucinating when they hear the "diesel idling" sound.

Here's part of the the abstract to a relevant paper:

Ann Otol Rhinol Laryngol. 1995 May;104(5):399-404.
Effects of L-baclofen and D-baclofen on the auditory system: a study of click-evoked potentials from the inferior colliculus in the rat.
Szczepaniak WS, M?ller AR.

"The drug baclofen is a potential treatment for severe tinnitus, but its action in relieving tinnitus is not known. Baclofen is available as an approved drug only in racemic form with about equal content of the two enantiomers. In the present paper we show that L-baclofen causes a considerable (40.7%) suppression of the amplitude of the second peak in the click-evoked response from the cochlear nucleus. ... D-Baclofen had no detectable effect on the response from the cochlear nucleus, and had only a slight effect on one component of the response from the external nucleus of the inferior colliculus. The demonstrated effect of L-baclofen on excitation in the ascending auditory pathway indicates that this drug may be a potential treatment for hyperactive auditory disorders such as tinnitus and hyperacusis."

[Lo0p]

Has anyone heard of STX209 or Arbaclofen?

Yup, we've definitely talked about it before:

Baclofen Potency

https://www.mywayout.org/community/f2...hlight=racemic

[MaryGoRound]

Has anyone heard of STX209 or Arbaclofen?

I wanted to post a note somewhere on these pages about a study where "male alcoholics demonstrate the same symptoms as autistic patients two weeks after being sober" ...don't take my quotes as literal since I haven't found the study again...although I know it is out there.

I am not looking too hard for the actual study but the idea stuck me. The only reason women are not mentioned is because they were not part of the study. The point is that alcoholics, in the study, had the same inability to respond to natural stimuli that autistic people have in their own world. This problem is a marked inability to see and respond to "normal" interpretation of events. It explains why we continually miss judge things even when we are not drunk.

Apparently BAC effects the same systems that effect autistic people. Some types of autistic people benefit form the same medicine that some alcoholics benefit from. I am not a doctor or medial professional so I am only make a jump in my interpretation. I cannot make a direct link but there may be similarities is some people with each type of condition.

it was not studied if the same alcoholic men continue to have the same problems interpreting events months after being sober. I guess we need more money to get a judge on that!

[TexasAg]

Has anyone heard of STX209 or Arbaclofen?

Mary I'll see if I can find a link to that study...

It's crazy but my wife teaches autistic kids and in researching I ran across Autism and baclofen with Bac treating the anxiety that these kids feel but can't articulate. It seems they have a similar inability to handle emotions and anxieties.

Funny thing is I've always caught myself doing repetitive things, counting, drawing, moving, stroking my head. My kids call me the master of useless info cuz I remember the stupidest details. They always want me on their trivia teams.

From another article:
"A link between savant syndrome and autism has been established. A link between artistic genius on the one hand and schizophrenia and manic-depression on the other, is widely debated"

"A study published this week by Patricia Howlin of King's College, London, reinforces this point. It suggests that as many as 30% of autistic people have some sort of savant-like capability in areas such as calculation or music. Moreover, it is widely acknowledged that some of the symptoms associated with autism, including poor communication skills and an obsession with detail, are also exhibited by many creative types, particularly in the fields of science, engineering, music, drawing and painting. Indeed, there is now a cottage industry in re-interpreting the lives of geniuses in the context of suggestions that they might belong, or have belonged, on the “autistic spectrum”, as the range of syndromes that include autistic symptoms is now dubbed."
Autism and extraordinary ability: Genius locus | The Economist

How many of these genius' had alcohol or other addiction problems?

So you see, maybe we're not terrible alcoholics.....we're just undercover genius'!

Cheers!

[TexasAg]

Has anyone heard of STX209 or Arbaclofen?

More Gee Whiz info:
Alcoholism Linked to Autism GeneFYI Living
Possible Link Between Alcoholism and Autism Gene

[TexasAg]

Has anyone heard of STX209 or Arbaclofen?

Agassi,

You mentioned you heard the diesel idling noise when you were titrating up. I'm guessing it went away? Did you have to stop titrating up?

Cheers!

[agassizii]

Has anyone heard of STX209 or Arbaclofen?

Tex,

Thanks for asking. I hit the switch, titrated back down, and don't notice it at a maintenance dose.

Glad to hear you're doing OK despite the occasional bump in the road. Pretty amazing stuff, huh?

I agree with you that the single isomer theory seems promising in possibly developing a low-SE version of "bac". Not sure anyone has addressed that head-on.

Loop,

Have you had the liquid form tested with regard to isomerism? Maybe some grad student at a local university would be interested in a project. :-)

Ag

[Lo0p]

Has anyone heard of STX209 or Arbaclofen?

I personally haven't. My predecessor may have, I'll check.

All I know is it's the right (meaning "good") one.

[emc]

Has anyone heard of STX209 or Arbaclofen?

this history of left (L-isomer) and right (R-isomer) of Baclofen its really intriguing me!!!

All the relations with autism as well...

Someone has test the Arbaclofen in place of Baclofen to kill the cravings?

It would really be a really revolutionary thing if exists the Baclofen without the ES of Baclofen! ;-)

[Otter]

Has anyone heard of STX209 or Arbaclofen?

TexasAg;1421882 wrote: I was researching Baclofen and autism and ran across this article:

New Version of an Old Drug Could Treat Autism (and Addiction Too) | TIME.com

From the Article:
"What Is Baclofen ? and STX209?
Like many drugs, baclofen contains two types of its main molecule, which are mirror images of each other. Often, one is an active ingredient, while the other is not. STX209, also known as arbaclofen, contains only the ?right-handed? molecule of baclofen, the drug?s active component. (More on Time.com: Building a Bridge to My Autistic Son: A Father?s Photo Journey)

According to Carpenter, STX209 is about 10 times more potent than baclofen. In mice with a genetic mutation similar to the one that produces Fragile X in humans, Seaside?s research found that the baclofen?s left-handed molecule did not have the same effect as STX209 and, in fact, actually increased anxiety-related behavior."





Anyone know anything about this Arbaclofen?

Loop? Anyone?

Cheers!

Roche have bought Seaside and the trials are ongoing. This is the problem with this forum. If you look back you will find all this dealt with when it came out. It is for autism though, and not for alcoholism. It would have to be trialled separately for alcoholism so again, it is not going to help until the bac trials finish in the US and France. In the meantime bac can be prescribed so by then, the grassroots growth of this treatment is likely to result in widescale use rather than new drugs coming on the market

[spiritwolf333]

Has anyone heard of STX209 or Arbaclofen?

As strange as this might seem, several weeks back I came across some drug research that mentioned autism and alcoholism. As usual, I even took the online aspbergers autism test. My wife teaches autistic children and they had even mentioned at one of her training classes how prevalent alcoholism was among the autistic. I'm not sure, but I think I even linked onto the info while researching adx drug. Anyway, here is a snippet of an article I found:

The link: Autism and Alcoholism are Genetically Linked | The Fix

Alcoholism in some people can be linked to a gene that also causes autism, found a recent study conducted in London. "A gene called Autism Susceptibility Candidate 2 (AUTS2) was associated with alcoholism," reported FYI Living. The study?which gathered data from 26,316 participants from 12 European populations?tracked how much alcohol each person consumed daily. The subjects' DNA was then examined for the AUTS2 gene. The researchers also used boozing mice to find out whether rodents with the AUTS2 gene hit the bottle harder: "A statistically significant association between amounts of alcohol consumed and AUTS2 gene expression was noted." So yes?the gene was found to be present in a higher-than-average number of alcoholic mice, as well as people. Scientists estimate that around 40% of alcoholics carry a genetic predisposition to their addiction ...

[JDizzle]

Has anyone heard of STX209 or Arbaclofen?

Hook Em!!!