Baclofen for opiate addiction

[redhead77]

Baclofen for opiate addiction

Apparently baclofen might be promising for opiate addiction and withdrawal. Thanks for all the links, Otter. The woman's story on how to avoid withdrawal? It's not a good example. How screwed up and sad.

[Ne/Neva Eva]

Baclofen for opiate addiction

From the only study Otter posted:

Finding that baclofen did not affect heroin intake is in con- trast with two previous investigations reporting baclofen as be- ing able to reduce heroin self-administration in trained rats. However, the first study (Xi and Stein, 1999) used different routes of administrations (i.e. intravenous and intracranial injec- tions), while the second (Brebner et al., 2002) employed a differ- ent schedule of reinforcement (i.e. progressive ratio) and detected an effect only at doses of baclofen (up to 5.6 mg/kg) much higher than that used in the present study. On the other hand, our findings are in line with those of Di Ciano and Everitt (2003) reporting the same range of doses we used as ineffective in altering active lever-pressing in rats trained to self-adminis- tered heroin under an FR1 schedule of reinforcement.

All of the others are accounts like the first one. In other words, they are individual anecdotes related by people looking to control opiate withdrawal, but not necessarily treat the underlying addiction. The couple that I read in their entirety take a daily dose of baclofen that is significant (>80mg) and deal with the SEs in order to avoid withdrawal.

EDIT: A couple of the links didn't work and I didn't go looking for them.

just sayin'

[Otter]

Baclofen for opiate addiction

Ne/Neva Eva;1483584 wrote: Okay.

Sorry about that.

:l