Nalmefene

[YouKayBee]

Nalmefene

Juan BH;1502275 wrote: This is an interesting development. I attemted TSM without success for about 14 months and gave up at the beginning of this year to try Baclofen. I have been having good results with the BAC so far, but have yet to find the "switch". It is early on still though and I am enjoying the anxiety relief

One of the things that worried me most about NAL was it's potential for liver damage, especially since I kept drinking a lot. If I remeber correctly, Nalmefene does not share this property with Naltrexone, but I think that they are both opiod antagonists and function the same in that manner. I will be keeping this in mind for the future. I wish we had a Dr Chick here in the States!
Juan BH;1502279 wrote: BTW budabelly- I think it is impossible to get addicted to an antagonist like Naltrexone or Nalmefene. They form a protective cap on your opiod receptors so that nothing can stimulate them. I hear you on not wanting to get your GP in the mix though. These things can be so difficult and pople just aren't ready to accept that this is truly a disease. It's kind of like when some people didn't want to hear that the earth was round! We will see a change in our lifetime I hope.

Liver damage by Naltrexone is a piece of mis-information. It only caused liver issues when they gave it in doses 6 times the recommended amount (300mg) for TSM to obese patients - being overweight/obese can cause strain on the liver itself. The main reason the liver would be recommended to be monitored by Drs whilst following TSM is because you are continuing to drink for it to work. The naltrexone simply isn't an issue for the liver, it has not been found at normal doses, even over years to cause any liver problems(well none I'm aware of). The Doctor attached to my local drug and alcohol team who provided recommendation and support to my GP to prescribe Naltrexone on the NHS wrote a letter saying there is no issue with long term use - he's more used to prescribing it to drug addicts to block opiods.

Naltrexone isn't an addictive drug because it doesn't produce ANY addictive effects, doesn't make you feel good or give you any type of positive feedback. If anything it does the opposite because of the way in which it works.

[Juan BH]

Nalmefene

I have been called to the carpet... Why?

[YouKayBee]

Nalmefene

Juan BH;1502297 wrote: I have been called to the carpet... Why?

If you mean because I quoted your threads, I'm not attacking you simply explaining and providing information on the stuff you posted. I can be a bit blunt at times, don't take it personally.

[Juan BH]

Nalmefene

Ukblonde;1502300 wrote: If you mean because I quoted your threads, I'm not attacking you simply explaining and providing information on the stuff you posted. I can be a bit blunt at times, don't take it personally.

Cool. We are in this together and I feel like I am hijacking a good thread!

[YouKayBee]

Nalmefene

Taken from wikipedia

Naltrexone has been reported to cause liver damage (when given at doses higher than recommended). It carries an FDA boxed warning for this rare side effect. Due to these reports, some physicians may check liver function tests prior to starting naltrexone, and periodically thereafter. Concerns for liver toxicity initially arose from a study of non-addicted obese patients receiving 300mg of naltrexone.[39] Subsequent studies have suggested limited toxicity in other patient populations.

[JoanC]

Nalmefene

Just looking at some of the Gabor Mate videos and enjoying - thanks for link

[Colin]

Nalmefene

Now I understand "I've started so I'll finish". World class pedantry, uh.

[Juan BH]

Nalmefene

Ukblonde;1502326 wrote: Taken from wikipedia

Naltrexone has been reported to cause liver damage (when given at doses higher than recommended). It carries an FDA boxed warning for this rare side effect. Due to these reports, some physicians may check liver function tests prior to starting naltrexone, and periodically thereafter. Concerns for liver toxicity initially arose from a study of non-addicted obese patients receiving 300mg of naltrexone.[39] Subsequent studies have suggested limited toxicity in other patient populations.

"One of the advantages of nalmefene, the sister compund to naltrexone, is that it is not metabolized in the liver, so doctors will not require liver function tests before prescribing it" (Eskapa, The Cure for Alcoholism, pg 109-110).

I am not knocking Naltrexone, but I do think that if Nalmefene poses less risk to an organ I have been neglecting for so many years, it is probably in my best interest to use it instead. My grandmother died of cirrhosis

I also think it is best to talk to a doctor about any of this if possible- baclofen, naltrexone, nalmefene, any of it. I really want that, but don't even know where to start looking around here. If anyone knows of a Dr. in Northern California willing and knowlegeable enough, please PM me!

[YouKayBee]

Nalmefene

Juan BH;1502391 wrote: "One of the advantages of nalmefene, the sister compund to naltrexone, is that it is not metabolized in the liver, so doctors will not require liver function tests before prescribing it" (Eskapa, The Cure for Alcoholism, pg 109-110)

I am not knocking Naltrexone, but I do think that if Nalmefene poses less risk to an organ I have been neglecting for so many years, it is probably in my best interest to use it instead. My grandmother died of cirrhosis

Yes I think Nalfemene will be a lot better than Naltrexone for a lot of people, and for a lot of reasons. The reason for my information post was that in the past some people have held back from trying Naltrexone because they'd heard the stories about it damaging the liver, and I just wanted the facts to be available. There'll still be folk who want to try Naltrexone or who don't wish to visit their Dr, and I'm not sure if Nalfemene is available online yet - I've also a good idea it'll be pretty expensive when/if it is.

[JoanC]

Nalmefene

Colin;1502382 wrote: Now I understand "I've started so I'll finish". World class pedantry, uh.

Ah now, the stuff on the shortened telomeres is good, you have to admit . I wonder can you regrow them, perhaps he will explain that in another video...

[Juan BH]

Nalmefene

I just got the book buddabelly. Gonna check it out tonight.