Dr Ameisen's titration schedule?

[john doe]

I can't seem to find it on-line anywhere (Haven't read the book though).

Did he use use the standard 3 dose schedule when going up and does he take his maintainence dose the same way or all at once seeing as its down to 50mg (?) per day?

[Siren136]

Dr Ameisen's titration schedule?

Here you go JD:

Dr. Ameisen's Baclofen Treatment

Here's Dr. L's schedule, as posted elsewhere on this site: https://www.mywayout.org/community/f2...ule-52878.html

[john doe]

Dr Ameisen's titration schedule?

Thanks Siren but what I wanted to really know was if Dr A used the standard 3 dose schedule?

Morning, noon, evening? It doesn't seen to give this anywhere.

[Ne/Neva Eva]

Dr Ameisen's titration schedule?

john doe;1508033 wrote: I can't seem to find it on-line anywhere (Haven't read the book though).

Did he use use the standard 3 dose schedule when going up and does he take his maintainence dose the same way or all at once seeing as its down to 50mg (?) per day?

It's in the book and the Lancet article. I don't remember it now. If you're looking to follow his schedule, I'd start there.

I also don't recall that his maintenance dose was 50mg/day. I believe that it's changed over the years, too. He hasn't published anything related to titration since the book/article many years ago. Our understanding of baclofen has come a long way since then. Have you seen the prescribing schedule by the French doctors? Pretty sure it would meet with OA's approval. Maybe not, but I am definitely sure they've done their research and come up with them based on what they think will work best.

[john doe]

Dr Ameisen's titration schedule?

I'm not particularly looking to follow his schedule I just wondered whether he doses 3 times a day. Would you have a link to the Lancet article Eva?

[Lo0p]

Dr Ameisen's titration schedule?

I thought I edited that part about 50mg/day out years ago. I heard him say it on a TV clip but I know it's not true today.

[StuckinLA]

Dr Ameisen's titration schedule?

From what I can remember, without the book at hand, yes he did a 3 times per day schedule. And his maintenance dose was something like 120/day. And he also uses an extra 20 or 30mg if he gets cravings or is about to do something particularly stressful, like public speaking. But that PRN (as needed) stuff seems to work for almost no one else around here.

Also, 3 times per day can get pretty ridiculous when you're in the higher doses. For the longest time I had serious issues with taking more than 50 at any one time. At least 4 times per day doses worked much better for me.

[EDIT: The book is super helpful, and a pretty good read (I think), but keep in mind Dr. A is just one dude. His experience is valuable, but there are a lot of others with valuable experiences, too. So it's best not to lionize him, ya' know?]

[Ne/Neva Eva]

Dr Ameisen's titration schedule?

I really recommend reading the book. It is the basis for ALL of this, after all. It also offers a really good understanding for not only the reasoning behind treating alcoholism with baclofen, but treating it with medication in general. It's available cheap on Amazon.

The other thing to keep in mind (and we often overlook it) about Ameisen's experience is that he took LDB for a year before he titrated down and then back up again. He was also mostly abstinent during that time. Two very important factors that are not at all the norm around here.

[john doe]

Dr Ameisen's titration schedule?

StuckinLA;1508100 wrote: From what I can remember, without the book at hand, yes he did a 3 times per day schedule.

Also, 3 times per day can get pretty ridiculous when you're in the higher doses. For the longest time I had serious issues with taking more than 50 at any one time. At least 4 times per day doses worked much better for me.


Cheers Stuck... That answers my question.

Regarding the 3 dose thing. My morning dose is 100mg. (100/75/75) I'm tolerating it pretty well and it should get easier in a few day. If and when I had to go over 300mg I'd maybe think about switching to a 4 dose plan.

Ne/Neva Eva;1508104 wrote:

The other thing to keep in mind (and we often overlook it) about Ameisen's experience is that he took LDB for a year before he titrated down and then back up again. He was also mostly abstinent during that time. Two very important factors that are not at all the norm around here.

I totally agree with the abstinent part. Luckily my drinking mostly stopped when I started with Baclofen. I couldn't imagine the SEs combined. I went up pretty quick and wouldn't change it if had to do it again as the SEs were tolerable. ( "juice worth the squeeze" I suppose)

I agree with titrating down 100%. Always true with any GABA agonist's.

[Ne/Neva Eva]

Dr Ameisen's titration schedule?

john doe;1508107 wrote: Cheers Stuck... That answers my question.

Regarding the 3 dose thing. My morning dose is 100mg. (100/75/75) I'm tolerating it pretty well and it should get easier in a few day. If and when I had to go over 300mg I'd maybe think about switching to a 4 dose plan.



I totally agree with the abstinent part. Luckily my drinking mostly stopped when I started with Baclofen. I couldn't imagine the SEs combined. I went up pretty quick and wouldn't change it if had to do it again as the SEs were tolerable. ( "juice worth the squeeze" I suppose)

I agree with titrating down 100%. Always true with any GABA agonist's.

And to my point...
He didn't get as high as 300mg.
He did not titrate down all the way until he decided to try to find what we now call the switch. And from memory, he didn't go all the way down. Just to...Nah, I won't guess.
And after he found he was indifferent? The book ends that he titrated down. After that? No one knows and he's never said explicitly...

Glad things are going so well for you, Juan. I've followed your journey and am very happy for you! Congratulations!

[Juan BH]

Dr Ameisen's titration schedule?

?Que?

I am following along Ne and thanks!

JD- I have talked to Dr. Levin recently. He said he is close to Dr. A and consults with him on how to administer the titration. It's a little too aggressive for me, as it increases the dose by 20mg a week. It does break the doses into three per day. The middle dose is consistently 30mg (after slowly getting baclofen into your system) i.e. week x: 50/30/50, week y: 60/30/60, week z: 70/30/70 and so on until indifference is achieved. This kind of allows you a break from the somnolence during the day. It does put a pretty heavy dose in you before bedtime though, which is why I went back to four even doses throughout the day. I have to get my sleep and fortunately I'm not stuck behind my desk all day at work.

You just need to try to find the method that works best for your situation. I'm thinking of changing mine up a bit, but I'll wait until the weekend in case any unexpected SEs result. Hope this helps. BTW i have the situation schedule typed out on a word document if you want it. Just let me know.

[john doe]

Dr Ameisen's titration schedule?

Cheers Juan. I'm currently on 100/75/75. I've just been playing it as it goes really but I think I'm not far off. I started off with a 2 dose schedule but ended up at this. I'm on a 9/1/5 schedule time wise. I've been having trouble sleeping and don't think it would help to leave my last dose any later.

SEs wise I'm doing fine. I felt somnolence when I jumped from 200 to 250 on Sunday(?) but its passed. I'm just in from a bike ride so I'd have felt it kicking in then I'd have thought. I'd been taking Xanax a few nights to sleep and this had more effect on the SEs I think.

[bleep]

Dr Ameisen's titration schedule?

I think the best thing to do is to experiment with your dose. Try taking lots of small doses throughout the day, or try taking a couple of bigger doses. Mix up the timing, and try and work out which schedule gives you the best results. Obviously if you are happy with the current version, there's no need to do this, but a lot of people really battle, and the best way to get around this, or at least to mitigate it, is to try lots of variations.