Baclofen Patent in 1979 for Anxiety, Neurosis, and Alcoholism

[Cassander]

Baclofen Patent in 1979 for Anxiety, Neurosis, and Alcoholism

spiritwolf333;1619189 wrote: Very true Cass -Good info and great post. However, I would like to point out that one might get a patent on HDB administration when combined with "other". I am not convinced that a patent would really do anything for the applicant.

I think the problem comes in with the "willingness" to be the first to step outside the box. As you noted and alluded to, when you see a rehabs step up and offer baclofen-gabapentin as true-first line recovery options, you will then see true progress in the reformation of alcoholics -and a real change in the industry will soon follow.

Love your cheerleading, spirit. So important in a recovery forum!

I agree that some combination patent (baclofen and another compound) is still conceivable. But that would be different than an "HDB Treatment" patent. It seems pretty clear that there will be no HDB Treatment patent.

But, as you say, that shouldn't prevent the rehab industry or, for that matter, the medical profession from using effective medical treatments. It will be nice when we get the results from a bona fide double blind HDB study. I'm hoping we can all agree on that.

Cassander

[spiritwolf333]

Baclofen Patent in 1979 for Anxiety, Neurosis, and Alcoholism

Cassander;1619377 wrote: Love your cheerleading, spirit. So important in a recovery forum!

I agree that some combination patent (baclofen and another compound) is still conceivable. But that would be different than an "HDB Treatment" patent. It seems pretty clear that there will be no HDB Treatment patent.

But, as you say, that shouldn't prevent the rehab industry or, for that matter, the medical profession from using effective medical treatments. It will be nice when we get the results from a bona fide double blind HDB study. I'm hoping we can all agree on that.

Cassander

Hi Cass -The combination of baclofen and "other" that I was referring to might not only be other medications but other combined services. Regardless of all else (a patent really would not be needed), a program that is put together for the recovery of addictions (primarily alcohol) using baclofen-gabapentin-naltrexone would end up having to be a success (or maybe its just another one of my delusions). In my opinion, a successful recovery program would involve not only the medications but also nutrition, exercise, connection, arts, etc. But, as we all know, talk is just -well, talk is just talk. Thanks for the post.

[Samandkatharine]

Baclofen Patent in 1979 for Anxiety, Neurosis, and Alcoholism

spiritwolf333;1618364 wrote: 90 percent of all alcoholics have a huge anxiety problem -pre alcohol. Alcohol is the cheapest-quickest-most available fix. Unless other medicines are introduced.



"And still we die.

Go figure.

Cassander"

Anti anxiety meds and SSRI meds never worked as well for me as Bac does. Once it did it's magic I figured out how much I suffered for 20 years, give or take.

I thank everyone on this board, and OA for saving the second half of my life. :l

Sam

[spiritwolf333]

Baclofen Patent in 1979 for Anxiety, Neurosis, and Alcoholism

Samandkatharine;1620251 wrote: Anti anxiety meds and SSRI meds never worked as well for me as Bac does. Once it did it's magic I figured out how much I suffered for 20 years, give or take.

I thank everyone on this board, and OA for saving the second half of my life. :l

Sam

Awesome Sam -thanks for the post!

[Mandiekinz]

Baclofen Patent in 1979 for Anxiety, Neurosis, and Alcoholism

Cassander;1619377 wrote: Love your cheerleading, spirit. So important in a recovery forum!

I agree that some combination patent (baclofen and another compound) is still conceivable. But that would be different than an "HDB Treatment" patent. It seems pretty clear that there will be no HDB Treatment patent.

But, as you say, that shouldn't prevent the rehab industry or, for that matter, the medical profession from using effective medical treatments. It will be nice when we get the results from a bona fide double blind HDB study. I'm hoping we can all agree on that.

Cassander

Excellent points to you, Ne, and Otter...

Just as there may never be a patent for it, the use of it in rehabs is a pretty bleak route at this time if you think about it...

There's no revenue.

Hence why there are always new drugs for different (often the same) problems appearing. Patents = money. You walk into a doctors office and ask for baclofen, they want you to try all of the other drugs they have advertised in their office.

Rehabs, push you out those doors, knowing you're going to come back. DOLLAHS!ointup:

There are dozens of different drugs that act on gaba-a, why not gaba-b?


"GABAA receptors are stimulatory ionotropic receptors that are the target of many commonly used drugs, especially sedatives. When a ligand binds to a GABAA (often allosteric) binding site, it allows chloride anions to penetrate the cell's ion channel, which hyperpolarizes the membrane channels of post-synaptic neurons and thus reduces their firing rate. The reduction in firing rate causes sedative and anxiolytic effects. These receptors exert their postsynaptic effects very quickly compared to GABAB receptors, since they're directly linked to ion channels unlike GABAB, which is coupled via a G protein.

Although GABAA-ρ receptors have a similar structure to other GABAA receptors, they are not targeted by many compounds that allosterically modulate most GABAA receptors. Many substances (such as benzodiazepines and barbiturates) that allosterically modulate GABAA do not modulate GABAA-ρ receptors.

GABAB receptors are inhibitory metabotropic receptors that elicit post-synaptic effects through a G protein signal cascade. They're generally targeted by drugs that cause muscular relaxation or, more recently, drugs that are attempting to cure some aspects of addiction. When the receptor is triggered, it basically "notifies" the G protein it's coupled to to exert effects on potassium channels and hyperpolarize neuronal membrane channels. Since more steps have to happen before effects are elicited with GABAB receptors, these receptors are generally slower to respond than GABAA receptors."

With that said, perhaps there may be a new gaba-b agonist drug to be made, not GHB or Phenibut (which also works on gaba-a) that can work just as well, can be patented, and accepted.

Do we have a chemist in the house? Either to correct me on this stuff or to unleash some creativity? And/or both.

Bottom line, it's probably not going to be accepted into the medical community so widely unless there is contractual money involved in some form. Business is business. Do they really care about the sick? Not when it comes to the entire ladder of the business. People are going to pass on eventually, but maybe they can squeeeeeze a few bucks out of them. Often starting at the idea of changing the world, but not being flexible once the banks get large and other hands get involved.

Perhaps in some way of lighting a fire under their butts with media and higher demand, someone will find a way to bend things around to make it happen.


Also, yes there was another thread from some time ago. I bumped it after I posted this one and did a little more digging. My apologies for double sharing. I'm shocked that there wasn't more said on it the matter back then.

[spiritwolf333]

Baclofen Patent in 1979 for Anxiety, Neurosis, and Alcoholism

Mandi -as you say "business is business". And got to agree, who is going to just hop in to business and be willing to break even or lose money just to help others? Well a few exist but not many. So, let us look at this from a different angle. If you were to have a rehab that became quite successful incorporating baclofen into their holistic healing protocol, then perhaps you may have a successful venture and money (profits) would no longer be the problem.

As I see the current situation now, no one exist now to step up to the plate and offer a "REAL" solution (using baclofen) -in a commercial way. As so many of know, baclofen offers a real "way out" from alcoholism. I sometimes ask myself why -why has no one even come remotely close to stepping up and saying here it is: "A new kind of rehab -that offers real solutions using state of the art protocols to resolve alcoholism". So, for now, we all keep talking the talk and hoping the hope. But until someone or some company steps up and says..... we are going to remain where we are. And their are legitimate doctors who will prescribe hdb -in the USA.

[Mandiekinz]

Baclofen Patent in 1979 for Anxiety, Neurosis, and Alcoholism

Again, I'm not saying people should work and invent out of the goodness in their hearts. I'm explaining that the larger picture...baclofen not being patented...it would be difficult to get that as a wide spread acceptable treatment when their is no ultimate revenue in it.

Theoretically, the finding of a new drug that's patentable could make headway.

Or open a rehab.

[spiritwolf333]

Baclofen Patent in 1979 for Anxiety, Neurosis, and Alcoholism

And Mandi - you are partially correct. However, please consider this; If whoever were to come out with a pill today that claimed -"alcohol free forever if you take this pill", how many would truly take this drug? Never mind, bad question and thought.

[Mandiekinz]

Baclofen Patent in 1979 for Anxiety, Neurosis, and Alcoholism

Hehe, that's hilarious! Hmmm....

I'm just saying...and I'm speaking this in 5th grade science ..and English...if there was a way to create a new gaba-b agonist...we already know what it does. It's just creating another drug in it's class.

Phenibut, apparently, is a cure
GHB, apparently, is a cure
Baclofen, apparently, is a cure

They're all gaba-b agonists.

It could then be patented, there will be money to push it's way into the markets and into people's mouths.

Just as benzos work in the gaba-a, but there are many different drugs in that class.

So it wouldn't be an entirely different drug being claimed as a new miracle drug...it'd be in the same class, just different structure.

...or as studies emerge and our community rises, more and more studies will under go. Thus, forcing baclofen forward and hopefully discovering a loop hole.

Until then, I guess you work on the rehab. I'll work on my PhD. :P

[spiritwolf333]

Baclofen Patent in 1979 for Anxiety, Neurosis, and Alcoholism

Mandiekinz;1620733 wrote: Hehe, that's hilarious! Hmmm....

I'm just saying...and I'm speaking this in 5th grade science ..and English...if there was a way to create a new gaba-b agonist...we already know what it does. It's just creating another drug in it's class.

Phenibut, apparently, is a cure
GHB, apparently, is a cure
Baclofen, apparently, is a cure

They're all gaba-b agonists.

It could then be patented, there will be money to push it's way into the markets and into people's mouths.

Just as benzos work in the gaba-a, but there are many different drugs in that class.

So it wouldn't be an entirely different drug being claimed as a new miracle drug...it'd be in the same class, just different structure.

...or as studies emerge and our community rises, more and more studies will under go. Thus, forcing baclofen forward and hopefully discovering a loop hole.

Until then, I guess you work on the rehab. I'll work on my PhD. :P

Hi Mandi -glad you were/are speaking on a 5th grade level; I can not stand that show "Are you smarter than a 5th grader" -bunch of little smart arses.

Studies here in the US will continue. People will continue to remain confused. Patents will be applied for and granted. But until any thing is put into practice, it will remain "talk therapy"; except for those on MWO who are damn near willing to try anything just to get sober.

Good post -and thanks.

[Mandiekinz]

Baclofen Patent in 1979 for Anxiety, Neurosis, and Alcoholism

Haha, I wasn't speaking IN a 5th grade level. I was speaking FROM a 5th grade level.

As in, the idea could be completely asinine and an idea of that of a mediocre 5th graders intelligence. :P

No patents will be applied for and granted on baclofen.

If fact, the studies on arbaclofen have been cancelled.

there's always Ibogane! hehe

[spiritwolf333]

Baclofen Patent in 1979 for Anxiety, Neurosis, and Alcoholism

Mandiekinz;1621035 wrote: No patents will be applied for and granted on baclofen.

If fact, the studies on arbaclofen have been cancelled -there's always Ibogane! hehe

Hi Mandi -there will be patents applied for regarding medications to resolve alcoholism and these patents will involve baclofen or baclofen type medications/mixtures. You are talking about addressing one of the most deadliest diseases ever known to mankind. However, keep in mind that is not in the best interest of many to eliminate this disease.

[Mandiekinz]

Baclofen Patent in 1979 for Anxiety, Neurosis, and Alcoholism

Yea, unfortunately...that is the case. However, we stand strong, continue to find doctors and research, something will give.

Time and time again, baclofen for alcohol and addiction keeps popping up. Evidently since the 70's. With our wonderful technology this day in age, to join together and communicate and spread word much easier, it's impossible to sweep this under the rug like it has in the past.

Ameisen made it possible by sending out the message to the world. It just took time for it to rise up.

The more media coverage and studies there are, the more we will find it more acceptable. We'll still probably have much better luck with a GP than a psych or rehab for now, but either way, it can continue to rise.

[emc]

Baclofen Patent in 1979 for Anxiety, Neurosis, and Alcoholism

Totally agree with spiritwolf...
There is no interest on finding a cure for alcoholism (as for many other diseases!) cause is much more profitable to "half cure" someone and having it as client (other medicaments, rehab, alchool consumer obviously) for all his life :-(
It's a profitable loop that they don't want to break...

In Pubmed is really full of documents that, starting from the half 70s, shows already the potential benefit of GabaB drugs...
This is the first i found, 1976:
Suppression of ethanol-induced locomotor stimulation by GABA-like drugs
or this:
"...The results suggest that baclofen reduces impulse flow in dopaminergic neurons..."

but there are many many others...

What i mean is that there are a lot of studies pointing on that direction until the well know Addolorato one but nobody seems to ever put attention on somth like this... for example:
1993, in Russia, 90th patients... they don't mention alchol consumption but more about on anxiety and depression but anyway...
Baclofen administration for the treatment of affective disorders in alcoholic patients.

I'm compiling a sort of "history of Baclofen" and GabaB related medical documents.
I will share it somewhere when available...

At next ;-)