started with baclofen..

[neophyte]

started with baclofen..

lewis123;1629465 wrote: What i mean is, if there is no money to be made by baclofen etc. Why not make a new medicin, with the same ingedrients as baclofen, and make a patent for alcoholism? But i can maybe sound unrealistic now it's just a question

it being out of patent is really the main problem. with so many people affected by alcoholism, there is a huge market for anti craving drugs given that they would need to be taken consistently. maybe when baclofen comes more prevalent a pharmaceutical company will tweek the molecule slightly to do the same thing but slap a patent on it, and market it as having some benefit over baclofen. Even if that happened, it would be a positive out come i think, at least there would be some more awareness around the subject, instead of seeing the disease as a moral failing and going to AA, its actually better treated with medication / therapy.

government should have an incentive to fund it also, so much gdp is lost due to alcoholism, lost productivity and strain on the health care system, but i dont see it happening.

[lewis123]

started with baclofen..

neophyte;1629554 wrote: it being out of patent is really the main problem. with so many people affected by alcoholism, there is a huge market for anti craving drugs given that they would need to be taken consistently. maybe when baclofen comes more prevalent a pharmaceutical company will tweek the molecule slightly to do the same thing but slap a patent on it, and market it as having some benefit over baclofen. Even if that happened, it would be a positive out come i think, at least there would be some more awareness around the subject, instead of seeing the disease as a moral failing and going to AA, its actually better treated with medication / therapy.

government should have an incentive to fund it also, so much gdp is lost due to alcoholism, lost productivity and strain on the health care system, but i dont see it happening.

Ok i think i understand it. So even if for example i make a slightly diferent sort od baclofenn and take a patent on it, and sell it for example for 10 euro's, than probably people will still buy baclofenn because its almost the same and only costs 1 euro..? Correct?

And what does a patent says? That u can not change the indication? Or that u cannot chance the substance?

But i understand the problem that why would invest someone 500K when nobody (except we) has benefit (financially) from it. And why is it not possible to for example move the price up off baclofen and indicate it for alcoholisme to so they can make some money out of it? Or that is the thing of a patent i guess?

Btw everything is going great btw! Still feeling super good, did so many things this week I always wanted to do

Grtz

[Xadrian]

started with baclofen..

lewis123;1629908 wrote: Ok i think i understand it. So even if for example i make a slightly diferent sort od baclofenn and take a patent on it, and sell it for example for 10 euro's, than probably people will still buy baclofenn because its almost the same and only costs 1 euro..? Correct?

And what does a patent says? That u can not change the indication? Or that u cannot chance the substance?

But i understand the problem that why would invest someone 500K when nobody (except we) has benefit (financially) from it. And why is it not possible to for example move the price up off baclofen and indicate it for alcoholisme to so they can make some money out of it? Or that is the thing of a patent i guess?

Btw everything is going great btw! Still feeling super good, did so many things this week I always wanted to do

Grtz

Of course Big Pharma tried to alter the baclofen somewhat to get a new patent on it, but they did not succeed as yet.

It's just like the cancer medicines: there are plants that are way more effective than the existing, expensive medicines, but Big Pharma did not succeed to make the compounds artificially. And you can't get a patent on existing plants, so that's why expensive, less effective medicines are being subscribed.

[lewis123]

started with baclofen..

UPDATE:

today i'm not feeling very good, but first let's talk about yesterday.

Yesterday evening i cached up with one of my good friends. Normally we always have dinner and drinks on a Saturday night, most off the time (always probably) we go out and we're drunk. But yesterday i ordered a glass of wine in the restaurant, actually i didn't really wanted to drink wine but ok? my friend ordered one and i think because it's a habituate with him to drink i also ordered one. Thing is, i didn't finish my glass, when the waiter came to move up our empty plates he i told him that he can take my half empty glass. My friend asked me "if i am sick?". But i was feeling very good and i told him that i take a new medicine etc and that i finally feel great. (but i didnt had the feeling that he understands me, althought he's one of my best friends, he was always the one who didn't think i have a problem. and i think that's because he can't see that maybe he has a problem as well). Afterwards we went to a bar, and he ordered beer, but i ordered water. He asked me if i didn't want to have fun... So i told him that I am having a lot of fun! And i really did, is was laughing, we were talking, but i explained him that fun has nothing to do with alcohol for me now. That i wanted to drive home safely also etc. And i saw that he was thinking that "i am boring now", "where is the real Lewis" etc.

Offcourse he kept on drinking, and then it was 12 midnight and i said that i was going home. And did not freak out but he was like kinda pissed that it was our Saturday night and that we always go out and blablabla. And he told me dat i'm not normal anymore. I didnt get pissed and i just told him that actually i think i'm very normal now, that 99% of the people go to sleep before midnight, even on a Saturday evening. So eventually i went home and he called other friends to hang out with.

So i don't know why i tell you this (that's why this forum exists to tell your story's right?). But suddenly i have the feeling, and i think the feeling is the correct feeling, that one of my best friends just seems to be a drinking friend. Because he totally wasn't happy for me, he totally didn't understand it. So maybe i have to give him more time, but u know what? Actually i don't care what he thinks, it was just the 1ste "negative" experience i had in the last 2 weeks and i wanted to share it with you here on the forum.

So why i'm not feeling great today is (i think) because i didn't slept well. I was out of melatonin so maybe it's because of that i don't know. I did fall asleep pretty fast, but i woke up 1 hour later, normally i always wake up 5 hours later to go to the toilet but not 1 hour later, and i couldn't fall asleep again fast. And then i woke up at 6, after 5 hours of sleep and i couldn't get asleep again. So i "only" got 6 hours off sleep, normally i try to have about 8. But when i woke up i felt really tired, i had breakfast and my intention today was to do a lot of things because the weather is super nice. But i still felt very tired, and even a bit dizziness. It was that heavy that i had to lay in my couch (i never to this, never never never, i didn't do a nap during the day in 25y) I think i sometimes felt asleep because i had i nightmare.

What i also experience is that i am very thirsty today, i'm always a bit thirsty i always drink 2l water a day but today it's a bit different (i think). Edit: i think it's nothing, it's typical when i take i medicine i start feeling things that maybe i could also have on a normal day.. When i took rilatin i was really thirsty, a really dry mouth, but that's normal with methylfenidaat, now it's more a weird taste in my mouth. Maybe because i'm tired.

Anyways, i hope it are no SE and it's just because i didn't slept very well. And if it are SE than i will handle them. I hope it will get better because i have a lot of work as a dentist from morning till evening and can't effort it that well to be that tired! But ok? we will see.

What are the most side effects that u guys feel? And do they go away?

And reactions on my story are always welcome, i'm feeling always very well when i see someones reactions.

Have a nice day,

Lewis

[Xadrian]

started with baclofen..

lewis123;1630317 wrote: What are the most side effects that u guys feel? And do they go away?

And reactions on my story are always welcome, i'm feeling always very well when i see someones reactions.

Have a nice day,

Lewis

When at a steady level, most SE's will fade away, but as long as you go up or down, they may return.

The most common SE is lack of interest in alcohol. This SE does not fade away


There are a lot of other SE's, like somnolence or insomnolence, vivid dreams, sudden euphoria in the beginning of titration, headaches, etc., etc.
Everyone experiences one or more different SE's, so it's hard to predict which ones you will experience.

The short night sleep doesn't have to be related to baclofen, but could be a result of the reaction of your friend, or is just coincidence.
See how you will do the next nights and then you can draw your conclusion.

If the short sleep remains, you could take some sleeping aids, but I don't have experience with that, so you have to ask another.

Sometimes I wake up in the early morning (mostly 3 AM) and cannot get to sleep again.
Fortunately, this only happens once a month or so and it happens when I'm in a lot of stress, so I don't think it's baclofen related.

[lewis123]

started with baclofen..

i also think its coincidence, feeling good again

[Samandkatharine]

started with baclofen..

Hi Lewis,

SE vary person to person. Unsettling dreams and fractured sleep can make the next day hard. If I wake up early (3am) I will take my morning dose of Bac and it gets me back to sleep. I'm like you in that I need my sleep. I also tend to worry and early morning worry sessions are not ok!

I've lost a good friend because I don't finish a bottle of wine with her. Pre-Bac that's all we really had in common. The realization that friends can come or go because of alcohol is sad, but it's only one of many things we will have to deal with without AL to mask our insecurities.

Sam

[lewis123]

started with baclofen..

thanks for the replies.

I still don't get something :$

--> Why isn't it possible that "for example", we invest 1 million euro in a research / trail on a medicine that has kindoff the same substance as baclofen. So let's say this works out well and we take a patent on this medicine so doctors can prescribe this medicine for addictions.

Why wouldn't this work? Because than they don't have to prescribe baclofen off label ..

So i think i'm missing something

[Xadrian]

started with baclofen..

lewis123;1630475 wrote: thanks for the replies.

I still don't get something :$

--> Why isn't it possible that "for example", we invest 1 million euro in a research / trail on a medicine that has kindoff the same substance as baclofen. So let's say this works out well and we take a patent on this medicine so doctors can prescribe this medicine for addictions.

Why wouldn't this work? Because than they don't have to prescribe baclofen off label ..

So i think i'm missing something

I expect baclofen to be an approved and number 1 medicine for alcohol addiction in a few years.
We just have to wait untul more trials have been published.

But we don't want to wait that long, so we get it either off-label or at an online pharmacy.

Believe me, big pharma is trying really, really hard to fabricate something similar as baclofen to make BIG money, but they did not succeed as yet.
Otherwise we would have heard it already.

[neophyte]

started with baclofen..

Xadrian;1630507 wrote: I expect baclofen to be an approved and number 1 medicine for alcohol addiction in a few years.
We just have to wait untul more trials have been published.

But we don't want to wait that long, so we get it either off-label or at an online pharmacy.

Believe me, big pharma is trying really, really hard to fabricate something similar as baclofen to make BIG money, but they did not succeed as yet.
Otherwise we would have heard it already.

i agree, once stable on bac, its just too easy, virtually no sides (after some time) and cravings reduced, anxiety lower. its a damn wonder drug

[emc]

started with baclofen..

Hi Lewis,
just passing here to know how is going...
An small update will be really good! ;-)

[lewis123]

started with baclofen..

Wow, it's been a week since i posted something??

Ok? so update !!

I'm doing fine! But you guys were right, the happy feeling goes away. I just feel normal now.

What do i experience in a positive way?
--> I almost don't drink (1 glass max per evening), i don't smoke pot, don't smoke cigarettes. I don't think about alcohol, NEVER.
--> I like my job more, i don't ask myself so much questions anymore about what i want in life etc. I read books, i do the things i always wanted to do etc etc..

What are my negative experiences?
--> Sleep: i always wake up twice in the night, and i wake up at 6 in the morning and i can't fall asleep again. I take my melatonin like i always did (also before baclo). I fall asleep fast, but i wake up very early.
--> I'm very tired in the evening, i don't now if that's because of the baclofen, but i think it's because i wake up very early that it's normal that i'm tired in the evening. Problem i have with that for example is yesterday, i went for dinner with friends, after dinner they went to a pub, and i went home.. Problem is that i really wanted to do something with my friends, but i was soooo tired. Than again they started asking what is wrong with me etc.. Now again it's 20.30u, and i'm really tired again. There is a bday party this evening off one of my best friends and i'm really thinking about not going. It's not that i don't want to go but i'm just to tired. And a cup of coffee won't help. I don't think i can have fun when i'm so tired.

But i don't know, i think it's normal :s For example my mum and dad, they never drink, never! And they always go to bed around 10 and wake up every day at 7. It's normal that u get tired in the evening right? And all these years when i was tired in the evening i just drank alcohol, took a pill of rilatin, or did cocaine.. I never went out sober.

But i'm asking myself the question how my friends go out without doing cocain or taking rilatin.

Do u guys have any advice on this? Should i just accept the fact that now my life is "normal", and that u should take peace with is?

I also have a strange feeling, it's not craving, but it's something like "i maybe wanna have a feeling that i can't have sober, so i can have fun in the evening when i go out to a bday party". But don't understand me wrong, yesterday there was a friend of mine who offered me cocaine because he knew i was tired (he doesnt know i'm on bac), and i said no thanks, i'm going home!

Sooooo i can't explain what i feel in english, but what i have now is what i always wanted, being able to drink 1 glass, being able to say no to drugs, being totally craving free, etc.. I'm having real fun during the day, but in the evening something is missing. AND i know it's normal, i went out almost everyday the last 7 years, did alcohol or drugs almost everyday. So it's normal that my brains need time to have fun sober in the evening i think.

Maybe i have to look for a new hobby in the evening, a new kind of sport, something that gives me some adrenalin?

So any advice is welcom!! Or any reaction on my thoughts !! Tomorrow evening i'll post some other things what i'm thinking to do in the future.

Have a good night everyone.

ps: i'm doing really fine! It's not that i'm depressed or something But it's just a strange feeling that i have in the evening..

Oh i have one more question, should it maybe help to take my last dose of baclo later in the evening? Or more early in the afternoon? Or any advice on this? I'm still on low dose..

GReetz

[spiritwolf333]

started with baclofen..

lewis123;1633100 wrote: Wow, it's been a week since i posted something??

Ok? so update !!

I'm doing fine! But you guys were right, the happy feeling goes away. I just feel normal now.

What do i experience in a positive way?
--> I almost don't drink (1 glass max per evening), i don't smoke pot, don't smoke cigarettes. I don't think about alcohol, NEVER.
GReetz

Lewis -I just got to say this; I have NEVER heard of a more remarkable and amazing recovery as yours. Only a few weeks ago you were an alcoholic and now you don't even think about alcohol. Wow.

You are quite the inspiration for those of us who suffer from alcoholism -a very deadly disease.

[Otter]

started with baclofen..

Yeah, Lew, Gee willikers and golleeee!

Halleluah, praise the lord and pass the pumpkin pie.

[lewis123]

started with baclofen..

spiritwolf333;1633113 wrote: Lewis -I just got to say this; I have NEVER heard of a more remarkable and amazing recovery as yours. Only a few weeks ago you were an alcoholic and now you don't even think about alcohol. Wow.

You are quite the inspiration for those of us who suffer from alcoholism -a very deadly disease.

well i mean i don't think about it like i used to. I'm not thinking when i'm driving home in the evening "where of with who should i have drinks". I do think about it a lot but not in a craving way of thinking.