French baclofen Trial nearly over.

[Otter]

I was in Paris last week and met with Renaud de Beaurepaire who is heading the double blind trial of baclofen. The trial will be over in May and then the result will be published which will allow the drug to be licensed for alcoholism.

Dr. de Beaurepaire treats over 600 patients with baclofen. He and his colleagues are very surprised at the lack of interest in it outside France.

The French doctors will be setting up English and French web sites for doctors and patients and will be publishing papers in English, setting up conferences and generally pushing this forward.

So, good news!!

[spiritwolf333]

French baclofen Trial nearly over.

Otter;1628824 wrote: I was in Paris last week and met with Renaud de Beaurepaire who is heading the double blind trial of baclofen. The trial will be over in May and then the result will be published which will allow the drug to be licensed for alcoholism.

Dr. de Beaurepaire treats over 600 patients with baclofen. He and his colleagues are very surprised at the lack of interest in it outside France.

The French doctors will be setting up English and French web sites for doctors and patients and will be publishing papers in English, setting up conferences and generally pushing this forward.

So, good news!!

Good to read Otter. Also, I just made a post about a recovery center in Savannah GA who is using baclofen-naltrexone as a front line recovery tool. In their literature, they speak of France as a country having already have somewhat already licensed baclofen for use. This report WILL have an effect here in the states. Already does -even if only in a small way.

Non 12 Step Program | Assisted Recovery Centers of Georgia, Inc.

[emc]

French baclofen Trial nearly over.

hi Otter,
thanks for the news!
Here my contribute... the website/net for for French doctors specifically related to formation about Baclofen is already active.
Didn't know they wanted to make something in English too...
Here the link: RESAB - Reseau Addictions Baclofene

[Xadrian]

French baclofen Trial nearly over.

The results of the Dutch trial by the University of Amsterdam will be published in the near future also, so good news.

[Otter]

French baclofen Trial nearly over.

I don't think the lag time is as much as a year. That may be how long it takes to get it published but it wouldn't take that long to get the results to the government.

The RESAB site will be set up in English and German over the next year.

....I still find this exhausting. Where are the doctors in the English speaking world? What happened to the spirit of people like Ralph Nader, investigative journalism, public health campaigners???

What has happened to us? If someone came along with a cure for cancer we would hear about it but where are we? Posting on a health food forum under drug number three which almost got erased by accident this morning.

:bang:wazup::wazup:

[emc]

French baclofen Trial nearly over.

Otter;1628902 wrote: Where are the doctors in the English speaking world? What happened to the spirit of people like Ralph Nader, investigative journalism, public health campaigners???

What has happened to us? If someone came along with a cure for cancer we would hear about it but where are we? Posting on a health food forum under drug number three which almost got erased by accident this morning.

Agree with you, Otter.
As you probably know, in France they did arrive to make start the process of authorization thanks to few doctors engaged in the "Baclofen case" + the constant work of the people of the 2 forums. The work of Dr. Ameisen, obviously too.

The work they made in this last years was mainly concentrated in:
- writing comments in articles about alcoholism and saying what Baclofen is and how it works, often simply sharing their own experience...
- making, following and "promoting" the forums (actually 2, little bad i think but ok).
- trying to contact the doctors that were "open" to Baclofen and ask them to participate in some way.
- and then, later, making surveys, statistics, organizing conferences etc.
- much more that i'm omitting...

It's exactly what it should be done even in English.
This place, as it is right now is certainly not perfect, i already said this (sorry MWO and thanks anyway for giving us this place).
The new (Lo0p) forum can be the alternative but imo needs to be improved, more sections, better organized and surely needs a tons of links to rank higher - as i work on the web and on seo i will contact them to offer my collaboration...
We need also to work in social media to spread informations with dedicated websites and/or tools (i already started quite an year ago).

Talking and talking between us on how Baclofen is good and work... it will surely not take us anywhere.
Let's go beyond!

[skullbabyland]

French baclofen Trial nearly over.

Wow, interesting... thanks for the info, Otter. Definitely watching this with keen interest.

[Jazi's Mum]

French baclofen Trial nearly over.

As for why this gets no interest here in North America: FOLLOW THE MONEY

Thanks Otter for the good news, and for making it easier for us to continue this journey - because we certainly could use little good news.

[Otter]

French baclofen Trial nearly over.

JM, there is some truth to that. Dr. Beaurepaire told me that there is, in fact, a pharmaceutical company which has actively tried to undermine his works and his forum because they have invested in a different product but he says their efforts were ineffective.

I think his general impression of what is going on in the English speaking world is that it is a mess.

I have tried to explain here many times that one of the ways to get some action is, unfortunately, to pursue a doctor or two for negligence. If any industry fails to respond to new developments in public health and the result is that people suffer needlessly, or more than they would have if the doctors had known about the development, then they can be held liable and the only people who can do that are judges and juries. That is the way it happens in the US as it is a country which believes in free enterprise, limited state intervention etc. Sadly, though, I get a lot of flack here from people saying I keep saying "sue, sue, sue". It is just a matter of fact that a lot of things only change when someone goes to court and then insurance companies refuse to insure unless changes are made so they don't get sued again.

[gratitude]

French baclofen Trial nearly over.

thnks for the info otter.:thanks:
what ever happened to the pharms trying to to develop the baclofen-R that they could patent? i seem to remember someone talking about this on this forum? grat.

[Otter]

French baclofen Trial nearly over.

Roche too over the trials of that and spent millions on it. The trial results weren't as good as they expected so they close it down half way through.

There is now a website for parents whose kids were on it and are now asking the government to get involved because the parents of many of the children who were on it said it definitely worked. That is real big pharma stuff because they spent something like $50 million on the trial and then just gave up. I can't even imagine how they can spend that much and give up. Being cynical though, the little company that came up with the idea, Seaside, was bought by Roche so the founders of that got rich.

What else matters, one might say!

[Otter]

French baclofen Trial nearly over.

squeezed;1631840 wrote: Roche gave up on the drug (patented, potential billions in sales) not because "the trial results weren't as good as they expected". The trials, merely at Phase2, ended because there was NO demonstrable difference from placebo in the primary endpoints.

BigPharm gave up because it did not work in a clinical trial. Of course, it worked for SOME people. Geez, everything works for SOME people.

Why is it so hard to understand? Arbaclofen was tried for autistic kids; the company who stood to make big big bucks off it decided it didn't work; some kids got better (as did kids on vitamins, hypnotherapy, anything); their parents are screaming conspiracy.

For those who think that anecdotal experience is more important than well-conducted clinical trials, well there is no common ground. It is like arguing against creationists.

"Anecdotal experience" as you put it is, in real life, real human beings with serious health problems so for those "anecdotal" people this drug worked and it was far more important to them and their children than Roche's profits and the parents were quite right in being upset that their children didn't matter at all to anyone.

Obviously, for you, it is more important that there are clinical trials than that people for whom a drug works get that drug.

The only messages I think we need to take from your posts are:

1 Everyone should stop talking about baclofen until some double blind trial is completed and that the authorities say it is ok to talk about it and use it. In the meantime, the people who say it works for them are wrong. It doesn't work for them because everything goes through the brain, the mind is manifested in the brain, every drug works on every part of the brain. However, once the figures are published from a trial, then the people for whom baclofen now works will be right...the drug does work on the GABA b receptor to reduce alcoholic craving and it is a useful tool in treating alcoholism.

Thanks, I didn't realize until you came and told us, that the scientific mechanism only become effective in people's bodies once a clinical trial is completed. I will bear that in mind.

2. You don't actually believe any of what you are posting...because you are just playing a game here. You know baclofen works and you were one of the first to use it and you helped me and my wife use it. So, stop the game playing and do something useful with that thing between your ears.

[Xadrian]

French baclofen Trial nearly over.

squeezed;1631840 wrote: Roche gave up on the drug (patented, potential billions in sales) not because "the trial results weren't as good as they expected".

Would that patent be for sale for a reasonable price?

[emc]

French baclofen Trial nearly over.

We are moving a bit from the topic of the subject... but ok.

When i first saw the Arbaclofen "case" i thought it could be even an hope to replace Baclofen for us and finally be the Baclo 2.0
Seems less ES but i don't know if the L-isomer is so important for the "craving suppression".

Is not possible that maybe they know that if they find that works and with no ES they will cure too many disease at same time and too many people? ;-) Kidding... but only in half, obviously...

There is a thread about Arbaclofen Placarbil... maybe we continue to talk there?
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