i decide to open this thread to discuss about how Baclofen influences or not the sleep architecture (latency, quality, duration etc).
As we all know is still not fully understood how this molecule works and, as obviously, even sleep plays a crucial role for an equilibrate physical/psicological state.
I've found few docs about the subject (links here in the end) but i would like to know even something abour your sleep and the relation with your hour/dosage or anything else related.
I have alterated sleep from quite the beginning of the treatment (before, in the abstinent periods i always had a regular good sleep).
Now is stabilize on wake up always, every night, after 3-4 hours after falling asleep (at higher dosage was even 3-4 time per night).
Sometimes i have the impression that the body and mind are not fully rested/restored, and the "heavy head" it can be the result/sign.
I remember well the old morning good sensation after a deep sleep night...
I take my last dose at 8PM - 10mg and i go to bed quite always around 11PM/00. Stand up around 8,30-9.
I even notice that, when i was on higher dose (180mg) i was using this little "trick" to put alarm early (around 6AM) take 10/20mg and back to sleep (i recently read here someone else doing it). It seems that was good but after did not try quite anymore...
On the opposite side, taking last dose just before going to sleep was prolonging really a lot the the time to fall asleep.
The sleeping aids i think that they don't resolve nothing so i dont take them (try just Hydroxyzine/Atarax one time and i was not well at all).
As i saw even others (here and in other forums) having some kind of alterations of sleep while on therapy so it would be good if we share our experiences/informations about it and the "eventual" relations with posology.
Here some doc on subject that i just found (and read):
- Differential effects of sodium oxybate and baclofen on EEG, sleep, neurobehavioral performance, and memory.
- New pathways and data on rapid eye movement sleep behaviour disorder in a rat model.
- A review of sodium oxybate and baclofen in the treatment of sleep disorders.
- The effects of the GABA agonist, baclofen, on sleep and breathing. -> full PDF dowload here
- Sleep is differently modulated by basal forebrain GABA(A) and GABA(B) receptors.
- Effect of baclofen on sleep-related periodic leg movements.
- some general infos about sleep
- need some good link for sleep phases... i will add it here if someone suggest me...
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