Ketamine’s Antidepressant Efficacy is extended 4 weeks with a family history of AUD

[neophyte]

Ketamine’s Antidepressant Efficacy is Extended for at Least Four Weeks in Subjects with a Family History of an Alcohol Use Disorder

[Lostinspace]

Thanks for the info, neo. I had no idea that ketamine had any efficacy for depression, let alone greater efficacy for those of us with this problem. Very interesting!

[terryk]

Just read this, interesting. -tk

[Wilson1]

Researchers seeking volunteers to test effectiveness of ketamine in treating alcoholism - The i newspaper online iNews

[_serenity_]

Fellow MWO users: The above user (Wilson1) is the banned MWO member Spiritfree/Spiritwolf/befreenow/Alfree. Please report him and do not allow him to continue on this site. He has done nothing but cause drama and chaos.

[Ne/Neva Eva]

Ketamine...That was in the news a lot in years gone by. This study was only of 54 people, and it included a group on placebo (so not many actually getting ketamine), but it's still interesting. The conclusion:

Results: FHP subjects randomized to placebo had a greater antidepressant response than FHN subjects; however, contrary to our

initial hypothesis, there was no significant difference in antidepressant efficacy with riluzole. Although potentially underpowered,

there was no difference in overall time-to-relapse based on randomization status (riluzole responders: n*=*15, placebo responders:

n*=*17). Yet, time-to-relapse was longer in FHP placebo responders (n*=*8) compared to FHN placebo responders (n*=*9) with, again,

no significant difference in time-to-relapse in FHP riluzole responders (n*=*6) compared to FHN riluzole responders (n*=*9).

Conclusions: Ketamine??s extended antidepressant durability in FHP TRD should be considered in the design and analysis of

ketamine depression trials.