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    Baclofen and Gabapentin

    After much back and forth, I decided to add Gabapentin to my Baclofen regime. I did it because I have some fairly severe nerve pain in my legs that only started once I started the Baclofen. It is a side effect, though not at all common. I did quite a bit of research, and sat on the fence for a long while mostly because I hate taking pills and... a side effect of GabaP can be weight gain. :egad:

    Now today is only day 4, so I am no expert. But so far, so good. I finally took it because the bottom dropped out on my the other morning and I woke up feeling like someone died. I had been drinking some over the past week, but not a ton. For whatever reason, my mood was in the shitter. I had read that along with helping nerve pain and possibly helping with alcohol cravings, GabaP is a mood stabilizer. I am taking 100mg in am and another 100 at noon, another 100 at night. My mood immediately went back to neutral. I did feel a little drugged, but I don't mind that. It has helped anxiety, a lot! And the real kicker is that it has completely made me lose my drive to drink. Even though I didn't have any cravings on the dose of Bac I was on (80mg a day), I still was drinking. I could abstain, but mostly chose to drink. And it was a choice. With the GabaP that has been completely removed. Poof.

    I've read that getting off this stuff is hellish. I am hoping not to have to go up too much, though I've read that one does develop a tolerance and usually has to go up some. I am also going to go down a bit on the Baclofen and try and find a balance of the two. So far the nerve pain has not diminished so I'm going to try and get the Baclofen lower and see it that helps.

    That's my report for today. I am going to take the opportunity of no desire to drink to not drink. What a concept! It can be so tempting to drink a few here and there when there is no taste for it. But after 2 and a half years of messing around with alcohol while on baclofen, I feel like I am ready to try something different. But don't hold me to it. I am an alcoholic, afterall!

    #2
    Hi Dun -please keep reporting your progress. As you may already know, there are current medical trials underway that are combining the two meds -Balclofen and Gabapentin. The NIH continues to insist that Gabapentin can be a real answer for many.

    --sf--

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      #3
      dun - I wish you luck with gabapentin. Medications can all be so strange for all of us. That nerve pain you get on bac? I got that same pain in my legs with gabapentin, but never with bac (even though gabapentin is indicated to TREAT nerve pain, not cause it). Hmmmm. Anyway, I hope this will be the answer for you, either to start helping with the nerve pain, or at least to control your cravings enough that you can taper down on bac to a level that doesn’t cause you physical discomfort. That’s awesome that your mood and anxiety are already improved Keep us posted on how you’re doing.

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        #4
        I've read some reports that gabapentin can be much worse than benzodiazepines to get off, taking years to get back to normal. I don't know specifics but I would be careful and research everything. 200mg is a pretty low dose, ive read of people taking 3 grams of the stuff and more, so maybe youre fine.
        01-01-2014 - Indifference reached, success with high dose Baclofen 295mg.

        Baclofen prescribing guide

        Baclofen for alcoholism - Consolidated Information - Studies, prescribing guides, links

        Comment


          #5
          Well Dun, since taking Baclofen for over two years now, I have completely torn two calve muscles. Was this due due to Baclofen, who knows. Other physical muscle symptoms exist now now as well that did not exist before Baclofen. Regardless of these physical problems, I was quickly dying from AUD. so to me, it really does not matter what caused the physical problems. I am quite certain that I will revisit my Baclofen intake before too long and begin a program of reduction.

          Thanks for your post.

          Comment


            #6
            Originally posted by neophyte View Post
            I've read some reports that gabapentin can be much worse than benzodiazepines to get off, taking years to get back to normal. I don't know specifics but I would be careful and research everything. 200mg is a pretty low dose, ive read of people taking 3 grams of the stuff and more, so maybe youre fine.

            Neo is right about the Gabapentin withdrawal problems. Sometimes withdrawal from Gabapentin can be as bad the withdrawal from Baclofen. I have not read any studies relative GP and Benzos.

            Comment


              #7
              Hi,

              jut reading through and need to ask you what is AUD? I have never heard this before.

              I was taking 2700mg daily of gabapentin and changed to pregabalin a couple of months ago. I hve not felt right since but didn't think it could be caused by gabapentin withdrawals. If it is tho that is good news as it means I will eventually feel better.

              Comment


                #8
                Originally posted by medusa View Post
                Hi,

                jut reading through and need to ask you what is AUD? I have never heard this before.

                I was taking 2700mg daily of gabapentin and changed to pregabalin a couple of months ago. I hve not felt right since but didn't think it could be caused by gabapentin withdrawals. If it is tho that is good news as it means I will eventually feel better.
                Hi medusa (spacebabe) -AUD stands for Alcohol Use Disorder (new technical-defined term for alcoholism):

                "The Definition For 'Problem Drinking' Has Changed. Here's Why That Matters"

                "Problem drinking is more pervasive and less frequently treated than previously thought, thanks to an updated definition of what constitutes "alcohol use disorder."

                A study published on June 3 in the journal JAMA Psychiatry surveyed U.S. adults 18 and older on their alcohol consumption habits between 2012 and 2013. Results were analyzed using the definition of alcohol use disorder in the latest edition of the Diagnostic and Statistical Manual of Mental Disorders, which was published in 2013.

                While older editions divided alcohol use disorder into two categories, alcohol abuse and alcohol dependence, the new definition eliminated categories. Instead, it measures alcohol use disorder using a spectrum of abuse criteria ranging from mild to severe.

                The expanded definition of AUD includes a new criterion -- "craving" for alcohol -- and eliminates another: legal issues surrounding alcohol abuse. But the more significant change has been an update to the criteria for a diagnosis. Rather than a single definition, there's now a spectrum on which people can be diagnosed and treated based on whether they exhibit a few of symptoms or a more profound disorder."

                Hope this helps. --sf--

                Comment


                  #9
                  Spirit-you always take the time to post the most comprehensive and helpful information. I am so grateful. Thanks!!!!

                  Comment


                    #10
                    Originally posted by medusa View Post
                    Hi,

                    jut reading through and need to ask you what is AUD? I have never heard this before.

                    I was taking 2700mg daily of gabapentin and changed to pregabalin a couple of months ago. I hve not felt right since but didn't think it could be caused by gabapentin withdrawals. If it is tho that is good news as it means I will eventually feel better.
                    pregabalin is basically the stronger version of gabapentin, again be careful. many psychiatrists are giving these drugs out unaware of the sever dependence they can cause. again though, do some research, there are some horror stories online but then im not sure if they are reflective of the general users, the incidence of dependence etc etc
                    01-01-2014 - Indifference reached, success with high dose Baclofen 295mg.

                    Baclofen prescribing guide

                    Baclofen for alcoholism - Consolidated Information - Studies, prescribing guides, links

                    Comment


                      #11
                      Originally posted by neophyte View Post
                      pregabalin is basically the stronger version of gabapentin, again be careful. many psychiatrists are giving these drugs out unaware of the sever dependence they can cause. again though, do some research, there are some horror stories online but then im not sure if they are reflective of the general users, the incidence of dependence etc etc
                      Pregabalin and gabapentin share a similar mechanism of action, inhibiting calcium influx and subsequent release of excitatory neurotransmitters; however, the compounds differ in their pharmacokinetic and pharmacodynamic characteristics. Gabapentin is absorbed slowly after oral administration, with m …


                      Abstract
                      Pregabalin and gabapentin share a similar mechanism of action, inhibiting calcium influx and subsequent release of excitatory neurotransmitters; however, the compounds differ in their pharmacokinetic and pharmacodynamic characteristics. Gabapentin is absorbed slowly after oral administration, with maximum plasma concentrations attained within 3-4 hours. Orally administered gabapentin exhibits saturable absorption--a nonlinear (zero-order) process--making its pharmacokinetics less predictable. Plasma concentrations of gabapentin do not increase proportionally with increasing dose. In contrast, orally administered pregabalin is absorbed more rapidly, with maximum plasma concentrations attained within 1 hour. Absorption is linear (first order), with plasma concentrations increasing proportionately with increasing dose. The absolute bioavailability of gabapentin drops from 60% to 33% as the dosage increases from 900 to 3600 mg/day, while the absolute bioavailability of pregabalin remains at > or = 90% irrespective of the dosage. Both drugs can be given without regard to meals. Neither drug binds to plasma proteins. Neither drug is metabolized by nor inhibits hepatic enzymes that are responsible for the metabolism of other drugs. Both drugs are excreted renally, with elimination half-lives of approximately 6 hours. Pregabalin and gabapentin both show dose-response relationships in the treatment of postherpetic neuralgia and partial seizures. For neuropathic pain, a pregabalin dosage of 450 mg/day appears to reduce pain comparably to the predicted maximum effect of gabapentin. As an antiepileptic, pregabalin may be more effective than gabapentin, on the basis of the magnitude of the reduction in the seizure frequency. In conclusion, pregabalin appears to have some distinct pharmacokinetic advantages over gabapentin that may translate into an improved pharmacodynamic effect.

                      Comment


                        #12
                        Thanks for the replys and info much appreciated. I started back on bac yesterday and hve very jerky hands and my son keeps on asking me if I have been drinking beczuse of the way Im talking.

                        Not sure how slong since I drank, last week sometime maybe I have been struggling and craving which is why I have come back to this site and bought some bac.

                        Thanks
                        space x

                        Comment


                          #13
                          thanks spirit, interesting to know, sounds like Pregabalin is just an all round upgraded version of gabapentin
                          01-01-2014 - Indifference reached, success with high dose Baclofen 295mg.

                          Baclofen prescribing guide

                          Baclofen for alcoholism - Consolidated Information - Studies, prescribing guides, links

                          Comment


                            #14
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                              #15
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