New drug tested that I found but can't find much more about it.

[empyr3al]

I found this by watching a documentary on Ecstasy and/or MDMA. I've known MDMA to be used experimentally for PTSD and addiction treatment. But watching this documentary the tester of pills seized at Glastonbury Festival speculated the Ecstasy tablets that didn't test positive for MDMA had CPP in them. Curiously I had never heard of this name so I did some searching.

CPP - 2-chloro-6-(piperazin-1-yl)pyrazine, otherwise know as MK-212 and has been used in trials studying the treatment of Alcoholism.
MK-212 - DrugBank <-- This page indicated it was used to test on Alcoholism.

Does anyone have more info on this compound?


Unrelated but interesting as tested for alcoholism also. Cross linked down the steps of that I found. Doxepin (Sinequan) comes up within some searching cross correlated. dimethyl(3-{9-oxatricyclo[9.4.0.0³,⁸]pentadeca-1(15),3,5,7,11,13-hexaen-2-ylidene}propyl)amine. Doxepine, a tricyclic antidepressant of the dibenzoxepin type, is used to treat depression and anxiety and, topically, pruritus associated with eczema. Doxepin has substantial anticholinergic and sedative effects. The E (trans)-isomer is more active as a serotonin reuptake inhibitor while the Z-isomer acts as a sedative.

What did they do? Smash MDMA with a benzo?

[Rusty]

Re: New drug tested that I found but can't find much more about it.

[MENTION=23850]empyr3al[/MENTION], no, I am sorry but I am not familiar with this drug. Sorry!

[terryk]

Re: New drug tested that I found but can't find much more about it.

I found this by watching a documentary on Ecstasy and/or MDMA. I've known MDMA to be used experimentally for PTSD and addiction treatment. But watching this documentary the tester of pills seized at Glastonbury Festival speculated the Ecstasy tablets that didn't test positive for MDMA had CPP in them. Curiously I had never heard of this name so I did some searching.

CPP - 2-chloro-6-(piperazin-1-yl)pyrazine, otherwise know as MK-212 and has been used in trials studying the treatment of Alcoholism.
MK-212 - DrugBank <-- This page indicated it was used to test on Alcoholism.

Does anyone have more info on this compound?

This study: Pharmacologically induced alcohol craving in treatment seeking alcoholics correlates with alcoholism severity, but is insensitive to acamprosate says that (m)CPP *induces* alcohol craving, and this one: Neuroendocrine responses to serotonergic agents in alcoholics. - PubMed - NCBI uses MK-212 (which act on serotonin receptors) to test serotonergic deficits in alcoholics.

And from wikipedia: Despite its advertisement as a recreational substance, mCPP is actually generally considered to be an unpleasant experience and is not desired by drug users.[3] It lacks any reinforcing or hallucinogenic effects,[5][6] produces dysphoric, depressive, and anxiogenic effects in rodents and humans,[7][8] and can induce panic attacks in individuals susceptible to them.[9][10][11][12] It also worsens obsessive–compulsive symptoms in people with the disorder.[13][14][15]

Unrelated but interesting as tested for alcoholism also. Cross linked down the steps of that I found. Doxepin (Sinequan) comes up within some searching cross correlated. dimethyl(3-{9-oxatricyclo[9.4.0.0³,⁸]pentadeca-1(15),3,5,7,11,13-hexaen-2-ylidene}propyl)amine. Doxepine, a tricyclic antidepressant of the dibenzoxepin type, is used to treat depression and anxiety and, topically, pruritus associated with eczema. Doxepin has substantial anticholinergic and sedative effects. The E (trans)-isomer is more active as a serotonin reuptake inhibitor while the Z-isomer acts as a sedative.

What did they do? Smash MDMA with a benzo?

Tricyclic antidepressants in the treatment of alcoholism and drug abuse.

Weiss RD1, Mirin SM.
Author information
Abstract
Although the frequent coexistence of substance abuse and depression is widely recognized, studies assessing the efficacy of tricyclic antidepressants in patients who abuse alcohol and/or drugs have been problematic because of controversies about how to diagnose depression in this population, failure to measure plasma antidepressant levels, and inconsistent treatment outcome measures. Some studies have, however, demonstrated the effective use of specific tricyclic antidepressants in selected subgroups of substance abusers; for example, desipramine may facilitate initiation of cocaine abstinence, and doxepin may benefit certain opioid addicts. Although imipramine has shown only equivocal success in the treatment of alcoholics, preliminary studies of serotonin uptake inhibitors show some promise in this population. As research design in this field becomes more consistent, future studies may more clearly identify subgroups of chemically dependent patients who respond to specific antidepressant drugs.