Comprehensive Baclofen Information Thread

[Invited Guest Poster]

Essential Baclofen Research:

• The Prescribing Guide for Baclofen in the Treatment of Alcoholism - For Use by Physicians (2017) (2013)
  

Studies Showing Baclofen's Effectiveness in treating Alcoholism

• Safety and efficacy of baclofen in the treatment of alcohol-dependent patients. (abstract).
• Treating alcohol withdrawal with oral baclofen: a randomized, double-blind, placebo-controlled trial (abstract)
• High-dose baclofen for the treatment of alcohol dependence (BACLAD study): a randomized, placebo-controlled trial. (abstract) (full-text)
• Suppression of alcohol dependence using baclofen: a 2-year observational study of 100 patients. (abstract) (full-text)
• Abstinence and 'low-risk' consumption 1 year after the initiation of high-dose baclofen: a retrospective study among 'high-risk' drinkers. (abstract) (full-text)
• High-Dose Baclofen for Treatment-Resistant Alcohol Dependence. (abstract) (full-text)***
• The use of very high-doses of baclofen for the treatment of alcohol-dependence: A case series. (abstract) (full-text)
• Effectiveness and safety of baclofen for maintenance of alcohol abstinence in alcohol-dependent patients with liver cirrhosis: randomised, double-blind controlled study. (abstract) (full-text)***
• Correlates of baclofen effectiveness in alcohol dependence. (abstract) (full-text)
• Complete and prolonged suppression of symptoms and consequences of alcohol-dependence using high-dose baclofen: A self-case report of a physician. (abstract) (full-text)
• Suppression of symptoms of alcohol dependence and craving using high-dose baclofen. (abstract) (full-text)
• Off-label baclofen prescribing practices among French alcohol specialists: Results of a national online survey. (abstract) (full-text)
• Pharmacotherapy for Alcohol Dependence: The 2015 Recommendations of the French Alcohol Society, Issued in Partnership with the European Federation of Addiction Societies. (abstract)

Studies showing the Safety and Pharmacokinetics of long-term High-dose Baclofen treatment

• High-dose oral baclofen: Experience in patients with Multiple Sclerosis. (abstract) (full-text)
• Clinical and Pharmacokinetic Aspects of High Dose Oral Baclofen. (abstract) (full-text)

Baclofen Side-effects

• Tolerability of High-dose Baclofen in the Treatment of Patients with Alcohol Disorders: A Retrospective Study. (abstract) (full-text)
• Phenylethylamine-like properties of baclofen. (abstract) (full-text)
• The nocebo effect: patient expectations and medication side effects. (abstract) (full-text)

Baclofen Withdrawal (While Baclofen is not addictive in the conventional medical use of the word - tolerance, dose escalation, and drug cravings do not occur among recipients - physical dependence is a feature of medium to long term use in all users - IT IS VERY IMPORTANT TO NEVER STOP TAKING BACLOFEN ABRUPTLY, OR TO TAPER OFF TOO RAPIDLY)

• What to do if you are running out (or low on) Baclofen. (full-text)
• Delirium Associated With Baclofen Withdrawal: A Review of Common Presentations and Management Strategies (abstract) (full-text)

Baclofen Overdose (Baclofen is a very safe drug and serious injuries/fatalities due to misuse are extremely rare - even in the case of massive, deliberate overdose. That said, it is possible to hurt yourself by taking too much Baclofen at once)

• Baclofen Overdose: Defining the spectrum of toxicity (abstract) (full-text)